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drd1a dopamine receptor D1a [ Danio rerio (zebrafish) ]

Gene ID: 792634, updated on 27-Mar-2024

Summary

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Official Symbol
drd1aprovided by ZNC
Official Full Name
dopamine receptor D1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-130522-1
See related
Ensembl:ENSDARG00000071640 AllianceGenome:ZFIN:ZDB-GENE-130522-1
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
D1Aa; drd1; si:ch211-277c7.4
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in brain and inner ear. Human ortholog(s) of this gene implicated in hypertension and kidney failure. Orthologous to human DRD1 (dopamine receptor D1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 14
Exon count:
2
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (24041758..24045144)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (23745262..23747543)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene kinesin family member 3A Neighboring gene interleukin 4 Neighboring gene si:ch211-277c7.7 Neighboring gene muscle segment homeobox 2a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The effects of two stressors on working memory and cognitive flexibility in zebrafish (Danio rerio): The protective role of D1/D5 agonist on stress responses. Fontana BD, et al. Neuropharmacology, 2021 Sep 15. PMID 34175323
  2. Evolution of dopamine receptor genes of the D1 class in vertebrates. Yamamoto K, et al. Mol Biol Evol, 2013 Apr. PMID 23197594, Free PMC Article
  3. Behavioral plasticity and gene regulation in the brain during an intermittent ethanol exposure in adult zebrafish population. Paiva IM, et al. Pharmacol Biochem Behav, 2020 May. PMID 32194086
  4. Sleep deprivation caused a memory defects and emotional changes in a rotenone-based zebrafish model of Parkinson's disease. Lv DJ, et al. Behav Brain Res, 2019 Oct 17. PMID 31195038
  5. Inhibition of Lrrk2 reduces ethanol preference in a model of acute exposure in zebrafish. Paiva IM, et al. Prog Neuropsychopharmacol Biol Psychiatry, 2020 Jun 8. PMID 32032698

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The effects of two stressors on working memory and cognitive flexibility in zebrafish (Danio rerio): The protective role of D1/D5 agonist on stress responses.
    Title: The effects of two stressors on working memory and cognitive flexibility in zebrafish (Danio rerio): The protective role of D1/D5 agonist on stress responses.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables alpha2-adrenergic receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-inhibiting adrenergic receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
D(1) dopamine receptor
Names
dopamine receptor D1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    24041758..24045144
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021481156.1 → XP_021336831.1  D(1) dopamine receptor

    UniProtKB/TrEMBL
    A0A8M6Z261, E7F359
    Conserved Domains (2) summary
    cd14964
    Location:27 → 51
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:24 → 339
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. XM_021481157.1 → XP_021336832.1  D(1) dopamine receptor

    UniProtKB/TrEMBL
    A0A8M6Z261, E7F359
    Related
    ENSDARP00000096874.1, ENSDART00000106096.2
    Conserved Domains (2) summary
    cd14964
    Location:27 → 51
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:24 → 339
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394909.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    10846..14232
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017359120.2 → XP_017214609.1  D(1) dopamine receptor

    UniProtKB/TrEMBL
    A0A8M6Z261, E7F359
    Conserved Domains (2) summary
    cd14964
    Location:27 → 51
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:24 → 339
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. XM_021472789.1 → XP_021328464.1  D(1) dopamine receptor

    UniProtKB/TrEMBL
    A0A8M6Z261, E7F359
    Conserved Domains (2) summary
    cd14964
    Location:27 → 51
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:24 → 339
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein
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