Format

Send to:

Choose Destination

Aspa aspartoacylase [ Rattus norvegicus (Norway rat) ]

Gene ID: 79251, updated on 12-Jan-2022

Summary

Official Symbol
Aspaprovided by RGD
Official Full Name
aspartoacylaseprovided by RGD
Primary source
RGD:621693
See related
Ensembl:ENSRNOG00000019659
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables identical protein binding activity. Involved in central nervous system myelination and positive regulation of oligodendrocyte differentiation. Located in cytoplasm and nucleus. Used to study Canavan disease. Human ortholog(s) of this gene implicated in Canavan disease. Orthologous to human ASPA (aspartoacylase). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Kidney (RPKM 460.7), Brain (RPKM 63.0) and 5 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Aspa in Genome Data Viewer
Location:
10q24
Exon count:
11
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (57891704..57945267, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (59839693..59888244, complement)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene sedoheptulokinase Neighboring gene transient receptor potential cation channel, subfamily V, member 1 Neighboring gene transient receptor potential cation channel, subfamily V, member 3 Neighboring gene spermatogenesis associated 22 Neighboring gene olfactory receptor 1466

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC93407, MGC93408

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in central nervous system myelination IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in positive regulation of oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
aspartoacylase
Names
ACY-2
aminoacylase-2
NP_077375.2
XP_006246879.1
XP_006246880.1
XP_017453032.1
XP_038942843.1
XP_038942844.1
XP_038942846.1
XP_038942847.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024399.2NP_077375.2  aspartoacylase

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000220
    Conserved Domains (1) summary
    cl11393
    Location:10299
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    57891704..57945267 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086919.1XP_038942847.1  aspartoacylase isoform X6

    Conserved Domains (1) summary
    cd06909
    Location:11192
    M14_ASPA; Peptidase M14 Aspartoacylase (ASPA) subfamily
  2. XM_006246817.4XP_006246879.1  aspartoacylase isoform X4

    See identical proteins and their annotated locations for XP_006246879.1

    Related
    ENSRNOP00000076074.2, ENSRNOT00000093579.2
    Conserved Domains (2) summary
    cd06909
    Location:11247
    M14_ASPA; Peptidase M14 Aspartoacylase (ASPA) subfamily
    pfam04952
    Location:9247
    AstE_AspA; Succinylglutamate desuccinylase / Aspartoacylase family
  3. XM_006246818.4XP_006246880.1  aspartoacylase isoform X3

    UniProtKB/TrEMBL
    A0A1W2Q6K0
    Related
    ENSRNOP00000076282.1, ENSRNOT00000093482.2
    Conserved Domains (2) summary
    cd06909
    Location:11248
    M14_ASPA; Peptidase M14 Aspartoacylase (ASPA) subfamily
    pfam04952
    Location:9247
    AstE_AspA; Succinylglutamate desuccinylase / Aspartoacylase family
  4. XM_039086915.1XP_038942843.1  aspartoacylase isoform X1

    Related
    ENSRNOP00000072876.1, ENSRNOT00000084432.3
    Conserved Domains (1) summary
    cl11393
    Location:10299
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
  5. XM_039086916.1XP_038942844.1  aspartoacylase isoform X1

    Conserved Domains (1) summary
    cl11393
    Location:10299
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
  6. XM_017597543.2XP_017453032.1  aspartoacylase isoform X2

  7. XM_039086918.1XP_038942846.1  aspartoacylase isoform X5

    Related
    ENSRNOP00000050760.5, ENSRNOT00000049311.5
    Conserved Domains (1) summary
    cd06909
    Location:11205
    M14_ASPA; Peptidase M14 Aspartoacylase (ASPA) subfamily
Support Center