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Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 79243, updated on 30-Sep-2021

Summary

Official Symbol
Hsd17b2provided by RGD
Official Full Name
hydroxysteroid (17-beta) dehydrogenase 2provided by RGD
Primary source
RGD:621803
See related
EnsemblRapid:ENSRNOG00000013982
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
17-beta hydroxysteroid enzyme that regulates the biological activity of sex hormones, including estrogen and androgens [RGD, Feb 2006]
Expression
Restricted expression toward (RPKM 603.8) See more
Orthologs
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Genomic context

See Hsd17b2 in Genome Data Viewer
Location:
19q12
Exon count:
5
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (45753576..45825203)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (50246404..50317892)

Chromosome 19 - NC_051354.1Genomic Context describing neighboring genes Neighboring gene phospholipase C, gamma 2 Neighboring gene uncharacterized LOC120098492 Neighboring gene short chain dehydrogenase/reductase family 42E, member 1 Neighboring gene M phase phosphoprotein 6 Neighboring gene uncharacterized LOC120098532

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in androgen biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in bone development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to metal ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in estrogen biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
 
involved_in placenta development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within placenta development ISO
Inferred from Sequence Orthology
more info
 
involved_in response to retinoic acid IEA
Inferred from Electronic Annotation
more info
 
involved_in response to retinoic acid ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
estradiol 17-beta-dehydrogenase 2
Names
17-beta-HSD 2
17-beta-hydroxysteroid dehydrogenase 2
17-beta-hydroxysteroid dehydrogenase type 2
testosterone 17-beta-dehydrogenase
NP_077367.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024391.2NP_077367.2  estradiol 17-beta-dehydrogenase 2

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000313
    Related
    ENSRNOP00000018795.2, ENSRNOT00000018795.4
    Conserved Domains (1) summary
    cd09805
    Location:84364
    type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051354.1 Reference mRatBN7.2 Primary Assembly

    Range
    45753576..45825203
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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