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Hpgd 15-hydroxyprostaglandin dehydrogenase [ Rattus norvegicus (Norway rat) ]

Gene ID: 79242, updated on 23-May-2018
Official Symbol
Hpgdprovided by RGD
Official Full Name
15-hydroxyprostaglandin dehydrogenaseprovided by RGD
Primary source
RGD:620087
See related
Ensembl:ENSRNOG00000010610
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
NAD+-dependent 15-hydroxyprostaglandin dehydrogenase [RGD, Feb 2006]
Expression
Biased expression in Lung (RPKM 301.9), Kidney (RPKM 262.4) and 5 other tissues See more
Orthologs
See Hpgd in Genome Data Viewer
Location:
16p11
Exon count:
7
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (37457134..37495758, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 16 NC_005115.3 (37259044..37296863, complement)

Chromosome 16 - NC_005115.4Genomic Context describing neighboring genes Neighboring gene centrosomal protein 44 Neighboring gene similar to myc induced nuclear antigen Neighboring gene high mobility group box 1 pseudogene Neighboring gene similar to ABT1-associated protein

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
15-hydroxyprostaglandin dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
15-hydroxyprostaglandin dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
PubMed 
15-hydroxyprostaglandin dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
 
15-hydroxyprostaglandin dehydrogenase (NAD+) activity ISS
Inferred from Sequence or Structural Similarity
more info
 
NAD binding ISO
Inferred from Sequence Orthology
more info
 
NAD binding ISS
Inferred from Sequence or Structural Similarity
more info
 
NAD+ binding ISO
Inferred from Sequence Orthology
more info
 
NAD+ binding ISS
Inferred from Sequence or Structural Similarity
more info
 
catalytic activity ISO
Inferred from Sequence Orthology
more info
 
catalytic activity ISS
Inferred from Sequence or Structural Similarity
more info
 
prostaglandin E receptor activity ISO
Inferred from Sequence Orthology
more info
 
prostaglandin E receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
ductus arteriosus closure ISO
Inferred from Sequence Orthology
more info
 
ductus arteriosus closure ISS
Inferred from Sequence or Structural Similarity
more info
 
female pregnancy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
female pregnancy IEP
Inferred from Expression Pattern
more info
PubMed 
female pregnancy ISO
Inferred from Sequence Orthology
more info
 
female pregnancy ISS
Inferred from Sequence or Structural Similarity
more info
 
kidney development IEP
Inferred from Expression Pattern
more info
PubMed 
negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
ovulation ISS
Inferred from Sequence or Structural Similarity
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
parturition ISO
Inferred from Sequence Orthology
more info
 
parturition ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of vascular smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
prostaglandin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
prostaglandin metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
prostaglandin metabolic process ISO
Inferred from Sequence Orthology
more info
 
prostaglandin metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
response to ethanol IDA
Inferred from Direct Assay
more info
PubMed 
response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
thrombin-activated receptor signaling pathway IEP
Inferred from Expression Pattern
more info
PubMed 
transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
transforming growth factor beta receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Names
15-PGDH
NAD-dependent 15-hydroxyprostaglandin dehydrogenase
PGDH
hydroxyprostaglandin dehydrogenase 15 (NAD)
prostaglandin dehydrogenase 1
NP_077366.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024390.2NP_077366.2  15-hydroxyprostaglandin dehydrogenase [NAD(+)]

    See identical proteins and their annotated locations for NP_077366.2

    Status: PROVISIONAL

    Source sequence(s)
    BC062399
    UniProtKB/Swiss-Prot
    O08699
    Related
    ENSRNOP00000014229.4, ENSRNOT00000014229.4
    Conserved Domains (2) summary
    cd05323
    Location:6254
    ADH_SDR_c_like; insect type alcohol dehydrogenase (ADH)-like, classical (c) SDRs
    pfam00106
    Location:6199
    adh_short; short chain dehydrogenase

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005115.4 Reference Rnor_6.0 Primary Assembly

    Range
    37457134..37495758 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000084.1 Alternate Rn_Celera

    Range
    33917230..33953504 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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