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hnf1ba HNF1 homeobox Ba [ Danio rerio (zebrafish) ]

Gene ID: 792391, updated on 6-May-2021

Summary

Official Symbol
hnf1baprovided by ZNC
Official Full Name
HNF1 homeobox Baprovided by ZNC
Primary source
ZFIN:ZDB-GENE-020104-1
See related
Ensembl:ENSDARG00000006615
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ho; ms; mst; vhn; hnf1; tcf2; hnf1b; vhnf1; chunp68; chunp6877
Orthologs
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Genomic context

See hnf1ba in Genome Data Viewer
Location:
chromosome: 15
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (15997149..16012968, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (16061127..16076941, complement)
103 previous assembly Zv9 (GCF_000002035.4) 15 NC_007126.5 (15016164..15031978, complement)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene dual specificity phosphatase 14 Neighboring gene synergin, gamma Neighboring gene dynein, light chain, LC8-type 2a Neighboring gene serine and arginine rich splicing factor 1a

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC158167

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein dimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within anterior/posterior pattern specification IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within anterior/posterior pattern specification involved in pronephros development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within digestive tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic digestive tract development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within endocrine pancreas development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endoderm formation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hepaticobiliary system development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within hindbrain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hindbrain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hindbrain morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within insulin secretion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within intrahepatic bile duct development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within liver development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within liver development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within liver development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within liver morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within otic placode formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within otic vesicle formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within otolith development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within otolith morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within pancreas development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within pancreas development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within pancreas development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within pancreas regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within rhombomere 5 development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within rhombomere 5 morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within rhombomere 6 development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within rhombomere 6 morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within semicircular canal morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within tube formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within type B pancreatic cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IC
Inferred by Curator
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
hepatocyte nuclear factor 1-beta-A
Names
HNF-1-beta-A
HNF-1B-2
HNF-1B-A
HNF1 homeobox b
TCF-2
hepatocyte nuclear factor 1-beta
hepatocyte nuclear factor 1-beta-2
hob
transcription factor 2, hepatic
variant hepatic nuclear factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131880.3NP_571955.3  hepatocyte nuclear factor 1-beta-A

    See identical proteins and their annotated locations for NP_571955.3

    Status: VALIDATED

    Source sequence(s)
    BX511308
    UniProtKB/Swiss-Prot
    A1L1N5
    Related
    ENSDARP00000119593.1, ENSDART00000144138.3
    Conserved Domains (3) summary
    cd00086
    Location:241314
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04812
    Location:323540
    HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus
    pfam04814
    Location:12180
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    15997149..16012968 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021481477.1XP_021337152.1  hepatocyte nuclear factor 1-beta-A isoform X1

    Conserved Domains (3) summary
    cd00086
    Location:241314
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04812
    Location:323567
    HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus
    pfam04814
    Location:12180
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus
  2. XM_021481478.1XP_021337153.1  hepatocyte nuclear factor 1-beta-A isoform X2

    Conserved Domains (3) summary
    cd00086
    Location:111184
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04812
    Location:193437
    HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus
    pfam04814
    Location:150
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394942.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    10747..26561 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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