Format

Send to:

Choose Destination

Hmox2 heme oxygenase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 79239, updated on 12-Jan-2022

Summary

Official Symbol
Hmox2provided by RGD
Official Full Name
heme oxygenase 2provided by RGD
Primary source
RGD:67402
See related
Ensembl:ENSRNOG00000003773
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ho-2
Summary
Enables heme oxygenase (decyclizing) activity. Involved in response to oxidative stress. Predicted to be located in plasma membrane. Orthologous to human HMOX2 (heme oxygenase 2). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Testes (RPKM 274.1), Kidney (RPKM 164.3) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Hmox2 in Genome Data Viewer
Location:
10q12
Exon count:
8
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (10797076..10831178, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (10990034..11035493, complement)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene CG10869-like Neighboring gene cell death-inducing p53 target 1 Neighboring gene non-histone chromosomal protein HMG-17-like Neighboring gene uncharacterized LOC120095028 Neighboring gene NmrA like redox sensor 1 Neighboring gene DnaJ heat shock protein family (Hsp40) member A3

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables heme oxygenase (decyclizing) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables heme oxygenase (decyclizing) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables heme oxygenase (decyclizing) activity ISO
Inferred from Sequence Orthology
more info
 
enables heme oxygenase (decyclizing) activity TAS
Traceable Author Statement
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in heme catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in heme oxidation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in heme oxidation TAS
Traceable Author Statement
more info
PubMed 
involved_in iron ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
heme oxygenase 2
Names
heme oxygenase (decycling) 2
NP_001264002.1
NP_077363.1
XP_006245889.1
XP_038942842.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277073.1NP_001264002.1  heme oxygenase 2

    See identical proteins and their annotated locations for NP_001264002.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BF283242, FM110439, FM134576, FM139649, JACYVU010000217
    UniProtKB/Swiss-Prot
    P23711
    Related
    ENSRNOP00000005031.2, ENSRNOT00000005031.6
    Conserved Domains (2) summary
    cd19165
    Location:146173
    HemeO; kinked helix [structural motif]
    pfam01126
    Location:30235
    Heme_oxygenase; Heme oxygenase
  2. NM_024387.2NP_077363.1  heme oxygenase 2

    See identical proteins and their annotated locations for NP_077363.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    JACYVU010000217
    UniProtKB/Swiss-Prot
    P23711
    Conserved Domains (2) summary
    cd19165
    Location:146173
    HemeO; kinked helix [structural motif]
    pfam01126
    Location:30235
    Heme_oxygenase; Heme oxygenase

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    10797076..10831178 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086914.1XP_038942842.1  heme oxygenase 2 isoform X1

    Related
    ENSRNOP00000084166.1, ENSRNOT00000114400.1
    Conserved Domains (2) summary
    cd19165
    Location:146173
    HemeO; kinked helix [structural motif]
    pfam01126
    Location:30235
    Heme_oxygenase; Heme oxygenase
  2. XM_006245827.4XP_006245889.1  heme oxygenase 2 isoform X1

    See identical proteins and their annotated locations for XP_006245889.1

    UniProtKB/Swiss-Prot
    P23711
    Conserved Domains (2) summary
    cd19165
    Location:146173
    HemeO; kinked helix [structural motif]
    pfam01126
    Location:30235
    Heme_oxygenase; Heme oxygenase
Support Center