Hhex hematopoietically expressed homeobox [ Rattus norvegicus (Norway rat) ]

Gene ID: 79237, updated on 5-Jul-2025

Summary

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Official Symbol: Hhexprovided by RGD
Official Full Name: hematopoietically expressed homeoboxprovided by RGD
Primary source: RGD:619932
See related: Ensembl:ENSRNOG00000016595 AllianceGenome:RGD:619932
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hex
Summary: Enables sequence-specific DNA binding activity. Involved in several processes, including negative regulation of angiogenesis; negative regulation of transcription by RNA polymerase II; and negative regulation of vascular endothelial growth factor receptor signaling pathway. Predicted to be located in cytoplasm and nucleus. Predicted to be part of protein-DNA complex. Orthologous to human HHEX (hematopoietically expressed homeobox). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Adrenal (RPKM 159.7), Liver (RPKM 95.9) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Hhex in Genome Data Viewer

Location:: 1q53

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (244602945..244608532)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (235190455..235196042)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (256101994..256107581)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Vascular smooth muscle protein kinase CK2 inhibition suppresses neointima formation via a proline-rich homeodomain-dependent mechanism.
Title: Protein kinase CK2 inhibition suppresses neointima formation via a proline-rich homeodomain-dependent mechanism.
These findings suggest a role for HHEX in restricting axon growth in the developing central nervous system.
Title: The tumor suppressor HHEX inhibits axon growth when prematurely expressed in developing central nervous system neurons.

Submit: New GeneRIF Correction

General gene information

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Markers

D6S1641 (e-PCR)
- UniSTS:38404

Hhex (e-PCR), detects polymorphism
- UniSTS:516403

Hhex (e-PCR), detects polymorphism
- UniSTS:525497

AA957911 (e-PCR)
- UniSTS:239867

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding, bending	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables HMG box domain binding	IEA Inferred from Electronic Annotation more info
enables HMG box domain binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables eukaryotic initiation factor 4E binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables translation regulator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within B cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in B cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in DNA conformation change	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within Notch signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Notch signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within animal organ morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within animal organ morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in anterior/posterior pattern specification	IEA Inferred from Electronic Annotation more info
involved_in anterior/posterior pattern specification	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within common bile duct development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within common bile duct development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic heart tube development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic heart tube development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic organ development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic organ development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endoderm development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endoderm development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within forebrain development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within forebrain development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within forebrain morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within forebrain morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gallbladder development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gallbladder development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hemopoiesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hemopoiesis	ISO Inferred from Sequence Orthology more info
involved_in hemopoiesis	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within hepatic duct development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hepatic duct development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hepatoblast differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hepatoblast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hepatocyte differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hepatocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within interkinetic nuclear migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within interkinetic nuclear migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within liver development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within liver development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within morphogenesis of an epithelium	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within morphogenesis of an epithelium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organism growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myeloid leukocyte differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within myeloid leukocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytoplasmic translational initiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pancreas development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pancreas development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within primary lung bud formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within primary lung bud formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within primitive streak formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within primitive streak formation	ISO Inferred from Sequence Orthology more info
involved_in protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of leukocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of mRNA export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within thyroid gland development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within thyroid gland development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within tissue morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tissue morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vasculogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vasculogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-DNA complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: hematopoietically-expressed homeobox protein HHEX

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.