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ZNF557 zinc finger protein 557 [ Homo sapiens (human) ]

Gene ID: 79230, updated on 13-Mar-2020

Summary

Official Symbol
ZNF557provided by HGNC
Official Full Name
zinc finger protein 557provided by HGNC
Primary source
HGNC:HGNC:28632
See related
Ensembl:ENSG00000130544
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in testis (RPKM 1.5), thyroid (RPKM 1.3) and 25 other tissues See more
Orthologs

Genomic context

See ZNF557 in Genome Data Viewer
Location:
19p13.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (7069703..7087968)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (7069471..7087979)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene methyl-CpG binding domain protein 3 like 2 Neighboring gene methyl-CpG binding domain protein 3 like 3 Neighboring gene insulin receptor Neighboring gene Rho/Rac guanine nucleotide exchange factor 18 Neighboring gene uncharacterized LOC107985284

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC4054, FLJ96454

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 557
Names
CTB-25J19.9

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044387.2NP_001037852.1  zinc finger protein 557 isoform a

    See identical proteins and their annotated locations for NP_001037852.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein (isoform a).
    Source sequence(s)
    AC010606, BC003020, CD723611
    Consensus CDS
    CCDS42485.1
    UniProtKB/Swiss-Prot
    Q8N988
    Conserved Domains (6) summary
    smart00349
    Location:43100
    KRAB; krueppel associated box
    COG5048
    Location:137422
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:182202
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:320342
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:4382
    KRAB; KRAB box
    pfam13465
    Location:334359
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001044388.2NP_001037853.1  zinc finger protein 557 isoform b

    See identical proteins and their annotated locations for NP_001037853.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' coding region compared to variant 1. The resulting protein (isoform b) is shorter but has the same N- and C- termini compared to isoform a.
    Source sequence(s)
    AC010606, BC003020, CD723611
    Consensus CDS
    CCDS45945.1
    UniProtKB/Swiss-Prot
    Q8N988
    Related
    ENSP00000404065.2, ENST00000414706.2
    Conserved Domains (6) summary
    smart00349
    Location:3693
    KRAB; krueppel associated box
    COG5048
    Location:130415
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:175195
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:313335
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:3675
    KRAB; KRAB box
    pfam13465
    Location:327352
    zf-H2C2_2; Zinc-finger double domain
  3. NM_024341.3NP_077317.2  zinc finger protein 557 isoform a

    See identical proteins and their annotated locations for NP_077317.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer protein (isoform a). Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC010606, BC003020, CD723611
    Consensus CDS
    CCDS42485.1
    UniProtKB/Swiss-Prot
    Q8N988
    Related
    ENSP00000252840.5, ENST00000252840.11
    Conserved Domains (6) summary
    smart00349
    Location:43100
    KRAB; krueppel associated box
    COG5048
    Location:137422
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:182202
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:320342
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:4382
    KRAB; KRAB box
    pfam13465
    Location:334359
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    7069703..7087968
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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