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THOC6 THO complex 6 [ Homo sapiens (human) ]

Gene ID: 79228, updated on 7-Jun-2020

Summary

Official Symbol
THOC6provided by HGNC
Official Full Name
THO complex 6provided by HGNC
Primary source
HGNC:HGNC:28369
See related
Ensembl:ENSG00000131652 MIM:615403
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WDR58; fSAP35
Summary
This gene encodes a subunit of the multi-protein THO complex, which is involved in coordination between transcription and mRNA processing. The THO complex is a component of the TREX (transcription/export) complex, which is involved in transcription and export of mRNAs. A missense mutation in this gene is associated with a neurodevelopmental disorder called Beaulieu-Boycott-Innes syndrome. [provided by RefSeq, Dec 2016]
Expression
Ubiquitous expression in placenta (RPKM 12.6), skin (RPKM 10.4) and 25 other tissues See more
Orthologs

Genomic context

See THOC6 in Genome Data Viewer
Location:
16p13.3
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (3024035..3027750)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3074032..3077756)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene claudin 6 Neighboring gene TNF receptor superfamily member 12A Neighboring gene host cell factor C1 regulator 1 Neighboring gene BICD family like cargo adaptor 2 Neighboring gene uncharacterized LOC100128770 Neighboring gene matrix metallopeptidase 25 Neighboring gene MMP25 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of THO complex 6 homolog (THOC6) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, THO complex 6 homolog (THOC6), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with THOC6 is decreased by RRE PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2655

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
RNA export from nucleus TAS
Traceable Author Statement
more info
 
RNA splicing IEA
Inferred from Electronic Annotation
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
central nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA 3'-end processing TAS
Traceable Author Statement
more info
 
mRNA export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
mRNA export from nucleus TAS
Traceable Author Statement
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
viral mRNA export from host cell nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
THO complex IDA
Inferred from Direct Assay
more info
PubMed 
THO complex part of transcription export complex IDA
Inferred from Direct Assay
more info
PubMed 
nuclear body IDA
Inferred from Direct Assay
more info
 
colocalizes_with nuclear chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
nuclear speck IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcription export complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
THO complex subunit 6 homolog
Names
WD repeat domain 58
WD repeat-containing protein 58
functional spliceosome-associated protein 35

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052595.1 RefSeqGene

    Range
    5017..8732
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001142350.3NP_001135822.1  THO complex subunit 6 homolog isoform 2

    See identical proteins and their annotated locations for NP_001135822.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The encoded isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC108134, AK075330, BM457458, BX425088
    Consensus CDS
    CCDS45392.1
    UniProtKB/Swiss-Prot
    Q86W42
    Related
    ENSP00000253952.9, ENST00000253952.9
    Conserved Domains (3) summary
    COG2319
    Location:27266
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:2874
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:31265
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_001347703.2NP_001334632.1  THO complex subunit 6 homolog isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' structure, resulting in the use of a downstream start codon compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1
    Source sequence(s)
    BC003118, BM457458, BX425088
    Consensus CDS
    CCDS86500.1
    UniProtKB/Swiss-Prot
    Q86W42
    Related
    ENSP00000458295.1, ENST00000574549.5
  3. NM_001347704.2NP_001334633.1  THO complex subunit 6 homolog isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 and 4 encode trhe same isoform (1).
    Source sequence(s)
    AC108134, BM457458
    Consensus CDS
    CCDS10491.1
    UniProtKB/Swiss-Prot
    Q86W42
  4. NM_024339.5NP_077315.2  THO complex subunit 6 homolog isoform 1

    See identical proteins and their annotated locations for NP_077315.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 4 encode the same isoform.
    Source sequence(s)
    BC050674, BM457458, BX425088
    Consensus CDS
    CCDS10491.1
    UniProtKB/Swiss-Prot
    Q86W42
    Related
    ENSP00000326531.8, ENST00000326266.13
    Conserved Domains (3) summary
    COG2319
    Location:27274
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:2874
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:27285
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    3024035..3027750
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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