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Grid2 glutamate ionotropic receptor delta type subunit 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 79220, updated on 12-Jan-2022

Summary

Official Symbol
Grid2provided by RGD
Official Full Name
glutamate ionotropic receptor delta type subunit 2provided by RGD
Primary source
RGD:68368
See related
Ensembl:ENSRNOG00000006174
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
GluD2
Summary
Enables PDZ domain binding activity and identical protein binding activity. Involved in regulation of presynapse assembly. Located in postsynaptic density and postsynaptic membrane. Is active in glutamatergic synapse and parallel fiber to Purkinje cell synapse. Is integral component of postsynaptic density membrane. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 18. Orthologous to human GRID2 (glutamate ionotropic receptor delta type subunit 2). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Brain (RPKM 124.3), Uterus (RPKM 34.3) and 1 other tissue See more
Orthologs
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Genomic context

See Grid2 in Genome Data Viewer
Location:
4q31
Exon count:
18
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (92415019..93892472)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (94068112..95476864)

Chromosome 4 - NC_051339.1Genomic Context describing neighboring genes Neighboring gene histidine triad nucleotide binding protein 1, pseudogene 1 Neighboring gene thyroid stimulating hormone receptor, pseudogene 1 Neighboring gene uncharacterized LOC120102493 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC120102494 Neighboring gene atonal bHLH transcription factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables PDZ domain binding IEA
Inferred from Electronic Annotation
more info
 
enables PDZ domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
enables glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ionotropic glutamate receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables ligand-gated ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables molecular_function ND
No biological Data available
more info
 
enables scaffold protein binding IEA
Inferred from Electronic Annotation
more info
 
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in cellular protein localization IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular protein localization ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular protein localization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cerebellar granule cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cerebellar granule cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in cerebellar granule cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
involved_in excitatory synapse assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in excitatory synapse assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IEA
Inferred from Electronic Annotation
more info
 
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISO
Inferred from Sequence Orthology
more info
 
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in ionotropic glutamate receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in modulation of chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of long-term synaptic depression IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of long-term synaptic depression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synapse assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of synapse assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in prepulse inhibition IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within prepulse inhibition ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of postsynaptic density assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of postsynaptic density assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of presynapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of presynapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in synaptic transmission, glutamatergic IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of postsynaptic density membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of postsynaptic density membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
 
part_of ionotropic glutamate receptor complex IEA
Inferred from Electronic Annotation
more info
 
part_of ionotropic glutamate receptor complex ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in parallel fiber to Purkinje cell synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in parallel fiber to Purkinje cell synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in parallel fiber to Purkinje cell synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in parallel fiber to Purkinje cell synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in somatodendritic compartment ISO
Inferred from Sequence Orthology
more info
 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glutamate receptor ionotropic, delta-2
Names
gluR delta-2 subunit
glutamate receptor delta-2 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024379.2NP_077355.2  glutamate receptor ionotropic, delta-2 precursor

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000142
    Related
    ENSRNOP00000084985.1, ENSRNOT00000116787.1
    Conserved Domains (2) summary
    cd13731
    Location:440806
    PBP2_iGluR_delta_2; The ligand-binding domain of an orphan ionotropic glutamate receptor delta-2, a member of the type 2 periplasmic-binding fold protein superfamily
    cl10011
    Location:28429
    Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051339.1 Reference mRatBN7.2 Primary Assembly

    Range
    92415019..93892472
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017592903.2XP_017448392.1  glutamate receptor ionotropic, delta-2 isoform X1

    Related
    ENSRNOP00000096742.1, ENSRNOT00000111210.1
  2. XM_039108399.1XP_038964327.1  glutamate receptor ionotropic, delta-2 isoform X2

    Conserved Domains (2) summary
    cd13731
    Location:440806
    PBP2_iGluR_delta_2; The ligand-binding domain of an orphan ionotropic glutamate receptor delta-2, a member of the type 2 periplasmic-binding fold protein superfamily
    cl10011
    Location:28429
    Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
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