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Gdf10 growth differentiation factor 10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 79216, updated on 12-Aug-2018

Summary

Official Symbol
Gdf10provided by RGD
Official Full Name
growth differentiation factor 10provided by RGD
Primary source
RGD:621512
See related
Ensembl:ENSRNOG00000051993
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
may play a role in the central nervous system, in bone formation and remodeling [RGD, Feb 2006]
Annotation information
Annotation category: partial on reference assembly
Expression
Biased expression in Brain (RPKM 23.9), Uterus (RPKM 20.5) and 9 other tissues See more
Orthologs

Genomic context

See Gdf10 in Genome Data Viewer
Location:
16p16
Exon count:
3
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (10250508..10262383)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 16 NC_005115.3 (8571370..8583245)

Chromosome 16 - NC_005115.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108348435 Neighboring gene uncharacterized LOC102550656 Neighboring gene growth differentiation factor 2 Neighboring gene retinol binding protein 3 Neighboring gene zinc finger protein 488 Neighboring gene similar to tumor endothelial marker 8 isoform 1 precursor

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Adipogenesis, organism-specific biosystem (from WikiPathways)
    Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
transforming growth factor beta receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
SMAD protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cerebellum development IEP
Inferred from Expression Pattern
more info
PubMed 
fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of osteoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
osteoblast differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
ovulation cycle IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of osteoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of pathway-restricted SMAD protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of pathway-restricted SMAD protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of pathway-restricted SMAD protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of ossification IEP
Inferred from Expression Pattern
more info
PubMed 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
response to transforming growth factor beta IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
growth/differentiation factor 10
Names
BIP
BMP-3b
GDF-10
bone morphogenetic protein 3b
bone-inducing protein
prepro bone inducing protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024375.1NP_077351.1  growth/differentiation factor 10 precursor

    See identical proteins and their annotated locations for NP_077351.1

    Status: PROVISIONAL

    Source sequence(s)
    D49494
    UniProtKB/Swiss-Prot
    P55108
    Related
    ENSRNOP00000069581.1, ENSRNOT00000081183.1
    Conserved Domains (1) summary
    pfam00019
    Location:372475
    TGF_beta; Transforming growth factor beta like domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005115.4 Reference Rnor_6.0 Primary Assembly

    Range
    10250508..10262383
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000084.1 Alternate Rn_Celera

    Range
    5961266..5973147 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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