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Mtpn myotrophin [ Rattus norvegicus (Norway rat) ]

Gene ID: 79215, updated on 12-Jan-2022

Summary

Official Symbol
Mtpnprovided by RGD
Official Full Name
myotrophinprovided by RGD
Primary source
RGD:619806
See related
Ensembl:ENSRNOG00000011857
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gcdp
Summary
Enables sequence-specific DNA binding activity. Involved in several processes, including cellular response to mechanical stimulus; cerebellar granule cell differentiation; and regulation of macromolecule biosynthetic process. Located in axon; cytosol; and nucleus. Used to study hypertension. Biomarker of hypertension. Orthologous to human MTPN (myotrophin). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Brain (RPKM 514.8), Spleen (RPKM 475.5) and 9 other tissues See more
Orthologs
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Genomic context

See Mtpn in Genome Data Viewer
Location:
4q22
Exon count:
4
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (64159273..64186686, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (63012009..63039422, complement)

Chromosome 4 - NC_051339.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 180, member A Neighboring gene hypothetical LOC100365467 Neighboring gene U2 spliceosomal RNA Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Clone Names

  • MGC108675

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in catecholamine metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cerebellar granule cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in neuron differentiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cardiac muscle hypertrophy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cardiac muscle hypertrophy ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of macromolecule biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of barbed-end actin filament capping IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of barbed-end actin filament capping ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of barbed-end actin filament capping ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cell size ISO
Inferred from Sequence Orthology
more info
 
involved_in skeletal muscle tissue regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in striated muscle cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
part_of F-actin capping protein complex ISO
Inferred from Sequence Orthology
more info
 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
myotrophin
Names
V-1 protein
granule cell differentiation protein
growth factor
protein V-1
stimulates myocyte growth

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024374.4NP_077350.1  myotrophin

    See identical proteins and their annotated locations for NP_077350.1

    Status: PROVISIONAL

    Source sequence(s)
    BC088136
    UniProtKB/Swiss-Prot
    P62775
    Related
    ENSRNOP00000082083.1, ENSRNOT00000103488.1
    Conserved Domains (2) summary
    sd00045
    Location:632
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:697
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051339.1 Reference mRatBN7.2 Primary Assembly

    Range
    64159273..64186686 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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