cyt1l type I cytokeratin, enveloping layer, like [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cyt1lprovided by ZNC
Official Full Name: type I cytokeratin, enveloping layer, likeprovided by ZNC
Primary source: ZFIN:ZDB-GENE-061026-4
See related: Ensembl:ENSDARG00000036832 AllianceGenome:ZFIN:ZDB-GENE-061026-4
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable structural molecule activity. Predicted to be located in intermediate filament. Predicted to be active in cytoskeleton. Is expressed in trunk. Human ortholog(s) of this gene implicated in several diseases, including ectodermal dysplasia (multiple); focal nonepidermolytic palmoplantar keratoderma 1; pachyonychia congenita; steatocystoma multiplex; and white sponge nevus 2. Orthologous to several human genes including KRT13 (keratin 13); KRT14 (keratin 14); and KRT15 (keratin 15). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 19

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	19	NC_133194.1 (6290892..6292901, complement)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (5356421..5358430, complement)

Chromosome 19 - NC_133194.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fl13c12.x1 (e-PCR)
- UniSTS:201991

fc60c02 (e-PCR)
- UniSTS:189459

fa10g10.s1 (e-PCR)
- UniSTS:188804

fa03a08.s1 (e-PCR)
- UniSTS:202157

fc38e06.x1 (e-PCR)
- UniSTS:193734

fb34c02 (e-PCR)
- UniSTS:187086

fb34c02.x1 (e-PCR)
- UniSTS:190428

fb36c04 (e-PCR)
- UniSTS:187106

aa495494 (e-PCR)
- UniSTS:186865

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables structural constituent of skin epidermis	IBA Inferred from Biological aspect of Ancestor more info
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in morphogenesis of an epithelium	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in intermediate filament	IEA Inferred from Electronic Annotation more info
is_active_in keratin filament	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: type I cytokeratin, enveloping layer, like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.