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ABHD16A abhydrolase domain containing 16A, phospholipase [ Homo sapiens (human) ]

Gene ID: 7920, updated on 7-Jun-2020

Summary

Official Symbol
ABHD16Aprovided by HGNC
Official Full Name
abhydrolase domain containing 16A, phospholipaseprovided by HGNC
Primary source
HGNC:HGNC:13921
See related
Ensembl:ENSG00000204427 MIM:142620
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BAT5; NG26; PP199; hBAT5; D6S82E
Summary
A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. The protein encoded by this gene is thought to be involved in some aspects of immunity. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
Expression
Ubiquitous expression in testis (RPKM 19.9), prostate (RPKM 13.9) and 25 other tissues See more
Orthologs

Genomic context

See ABHD16A in Genome Data Viewer
Location:
6p21.33
Exon count:
21
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (31686955..31703324, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (31654726..31671137, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene lymphocyte antigen 6 family member G5B Neighboring gene lymphocyte antigen 6 family member G5C Neighboring gene uncharacterized LOC105375019 Neighboring gene uncharacterized LOC105375018 Neighboring gene microRNA 4646 Neighboring gene LY6G6F-LY6G6D readthrough Neighboring gene lymphocyte antigen 6 family member G6F Neighboring gene lymphocyte antigen 6 family member G6E

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with ABHD16A (BAT5); predicted interaction to be involved in antigenicity/immunity PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: LY6G6E

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
acylglycerol lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acylglycerol lipase activity IDA
Inferred from Direct Assay
more info
PubMed 
NOT lysophospholipase activity IDA
Inferred from Direct Assay
more info
PubMed 
palmitoyl-(protein) hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
monoacylglycerol catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
monoacylglycerol catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylserine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylserine catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
prostaglandin catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
phosphatidylserine lipase ABHD16A
Names
HLA-B associated transcript 5
abhydrolase domain containing 16A
abhydrolase domain-containing protein 16A
alpha/beta hydrolase domain-containing protein 16A
monoacylglycerol lipase ABHD16A
protein ABHD16A
protein G5
NP_001170986.1
NP_066983.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177515.2NP_001170986.1  phosphatidylserine lipase ABHD16A isoform b

    See identical proteins and their annotated locations for NP_001170986.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at an alternate AUG and result in an isoform (b) with a shorter, distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AI076373, AK297712, BC031839, BE272017, BP261875
    Consensus CDS
    CCDS54988.1
    UniProtKB/Swiss-Prot
    O95870
    UniProtKB/TrEMBL
    B3KNX9
    Related
    ENSP00000410347.2, ENST00000440843.2
    Conserved Domains (1) summary
    pfam12695
    Location:269401
    Abhydrolase_5; Alpha/beta hydrolase family
  2. NM_021160.3NP_066983.1  phosphatidylserine lipase ABHD16A isoform a

    See identical proteins and their annotated locations for NP_066983.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AI076373, AK023194, BC031839, BE272017, DC360732
    Consensus CDS
    CCDS4713.1
    UniProtKB/Swiss-Prot
    O95870
    UniProtKB/TrEMBL
    A0A1U9X777
    Related
    ENSP00000379282.3, ENST00000395952.8
    Conserved Domains (1) summary
    cl26327
    Location:280408
    Abhydrolase_1; alpha/beta hydrolase fold

RNA

  1. NR_033488.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI076373, AK055255, BE272017
    Related
    ENST00000492084.5
  2. NR_033489.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two internal exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI076373, AK308573, BC031839, BE272017, DC318775
    Related
    ENST00000495769.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    31686955..31703324 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p13 ALT_REF_LOCI_2

    Range
    3164245..3180613 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p13 ALT_REF_LOCI_3

    Range
    2934719..2951088 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 Reference GRCh38.p13 ALT_REF_LOCI_4

    Range
    2992002..3008372 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p13 ALT_REF_LOCI_5

    Range
    3028827..3045197 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p13 ALT_REF_LOCI_6

    Range
    2942780..2959156 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_7

Genomic

  1. NT_167249.2 Reference GRCh38.p13 ALT_REF_LOCI_7

    Range
    2986241..3002621 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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