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Osbpl5 oxysterol binding protein-like 5 [ Mus musculus (house mouse) ]

Gene ID: 79196, updated on 8-Dec-2022

Summary

Official Symbol
Osbpl5provided by MGI
Official Full Name
oxysterol binding protein-like 5provided by MGI
Primary source
MGI:MGI:1930265
See related
Ensembl:ENSMUSG00000037606 AllianceGenome:MGI:1930265
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ORP5; Obph1; Osbp2; 1110006M06Rik
Summary
Predicted to enable several functions, including cholesterol binding activity; phosphatidylserine transfer activity; and phospholipid binding activity. Predicted to be involved in phospholipid transport. Predicted to act upstream of or within lipid transport. Predicted to be located in endoplasmic reticulum-plasma membrane contact site. Predicted to be active in cytosol; intracellular membrane-bounded organelle; and membrane. Is expressed in several structures, including central nervous system; extraembryonic component; genitourinary system; immune system; and notochord. Orthologous to human OSBPL5 (oxysterol binding protein like 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 27.8), ovary adult (RPKM 26.8) and 24 other tissues See more
Orthologs
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Genomic context

See Osbpl5 in Genome Data Viewer
Location:
7 F5; 7 88.29 cM
Exon count:
25
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (143242499..143310745, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (143688762..143757008, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA E230032D23 gene Neighboring gene tumor necrosis factor receptor superfamily, member 22 Neighboring gene tumor necrosis factor receptor superfamily, member 23 Neighboring gene MAS-related GPR, member G Neighboring gene MAS-related GPR, member E

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cholesterol binding ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol-4-phosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylserine binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylserine transfer activity ISO
Inferred from Sequence Orthology
more info
 
enables sterol binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sterol transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in phospholipid transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phospholipid transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum-plasma membrane contact site ISO
Inferred from Sequence Orthology
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
oxysterol-binding protein-related protein 5
Names
ORP-5
OSBP-related protein 5
oxysterol binding protein 2
oxysterol binding protein homolog 1
oxysterol-binding protein-like protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199227.1NP_001186156.1  oxysterol-binding protein-related protein 5 isoform 2

    See identical proteins and their annotated locations for NP_001186156.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has a different exon at its 5' terminus which results in the use of a downstream in-frame translation initiation site, compared to variant 1. It encodes an isoform (2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    BC079872, BY234441, EH108768
    Consensus CDS
    CCDS57598.1
    UniProtKB/Swiss-Prot
    Q99NF5, Q9ER64
    Related
    ENSMUSP00000113362.2, ENSMUST00000119499.8
    Conserved Domains (3) summary
    cd13286
    Location:120248
    PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
    pfam00169
    Location:127243
    PH; PH domain
    pfam01237
    Location:373706
    Oxysterol_BP; Oxysterol-binding protein
  2. NM_001384163.1NP_001371092.1  oxysterol-binding protein-related protein 5 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 3, which encodes a shorter protein compared to isoform 1.
    Source sequence(s)
    AC068006, AC158299
    Conserved Domains (2) summary
    cd13286
    Location:132260
    PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
    pfam01237
    Location:385721
    Oxysterol_BP; Oxysterol-binding protein
  3. NM_024289.2NP_077251.1  oxysterol-binding protein-related protein 5 isoform 1

    See identical proteins and their annotated locations for NP_077251.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC068006, AC158299
    Consensus CDS
    CCDS40200.1
    UniProtKB/TrEMBL
    G5E833
    Related
    ENSMUSP00000020411.8, ENSMUST00000020411.14
    Conserved Domains (3) summary
    cd13286
    Location:144272
    PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
    pfam00169
    Location:151267
    PH; PH domain
    pfam01237
    Location:397730
    Oxysterol_BP; Oxysterol-binding protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    143242499..143310745 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508659.4XP_006508722.1  oxysterol-binding protein-related protein 5 isoform X2

    Conserved Domains (2) summary
    cd13286
    Location:72200
    PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
    pfam01237
    Location:325661
    Oxysterol_BP; Oxysterol-binding protein
  2. XM_011242024.1XP_011240326.1  oxysterol-binding protein-related protein 5 isoform X1

    Conserved Domains (2) summary
    cd13286
    Location:120248
    PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
    pfam01237
    Location:373676
    Oxysterol_BP; Oxysterol-binding protein

RNA

  1. XR_001778018.2 RNA Sequence