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IRX1 iroquois homeobox 1 [ Homo sapiens (human) ]

Gene ID: 79192, updated on 17-Jun-2019

Summary

Official Symbol
IRX1provided by HGNC
Official Full Name
iroquois homeobox 1provided by HGNC
Primary source
HGNC:HGNC:14358
See related
Ensembl:ENSG00000170549 MIM:606197
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IRX-5; IRXA1
Summary
This gene encodes a member of the Iroquois homeobox protein family. Homeobox genes in this family are involved in pattern formation in the embryo. The gene product has been identified as a tumor suppressor in gastric (PMID: 21602894, 20440264) and head and neck cancers (PMID: 18559491). A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Dec 2011]
Expression
Biased expression in kidney (RPKM 2.5), salivary gland (RPKM 1.1) and 4 other tissues See more
Orthologs

Genomic context

See IRX1 in Genome Data Viewer
Location:
5p15.33
Exon count:
4
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (3595832..3601403)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (3596168..3601517)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1019 Neighboring gene long intergenic non-protein coding RNA 1017 Neighboring gene VISTA enhancer hs261 Neighboring gene uncharacterized LOC107986399 Neighboring gene uncharacterized LOC105374625

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

General protein information

Preferred Names
iroquois-class homeodomain protein IRX-1
Names
homeodomain protein IRXA1
iroquois homeobox protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024337.4NP_077313.3  iroquois-class homeodomain protein IRX-1

    See identical proteins and their annotated locations for NP_077313.3

    Status: VALIDATED

    Source sequence(s)
    AC016595, AY335938, BC029160
    Consensus CDS
    CCDS34132.1
    UniProtKB/Swiss-Prot
    P78414
    Related
    ENSP00000305244.3, ENST00000302006.4
    Conserved Domains (2) summary
    pfam05920
    Location:145184
    Homeobox_KN; Homeobox KN domain
    cl01319
    Location:188247
    HARE-HTH; HB1, ASXL, restriction endonuclease HTH domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    3595832..3601403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009845.1XP_016865334.1  iroquois-class homeodomain protein IRX-1 isoform X1

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