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FSD1 fibronectin type III and SPRY domain containing 1 [ Homo sapiens (human) ]

Gene ID: 79187, updated on 5-Aug-2022

Summary

Official Symbol
FSD1provided by HGNC
Official Full Name
fibronectin type III and SPRY domain containing 1provided by HGNC
Primary source
HGNC:HGNC:13745
See related
Ensembl:ENSG00000105255 MIM:609828; AllianceGenome:HGNC:13745
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIR1; GLFND
Summary
This gene encodes a centrosome associated protein that is characterized by an N-terminal coiled-coil region downstream of B-box (BBC) domain, a central fibronectin type III domain, and a C-terminal repeats in splA and RyR (SPRY) domain. The encoded protein associates with a subset of microtubules and may be involved in the stability and organization of microtubules during cytokinesis. [provided by RefSeq, Apr 2009]
Expression
Biased expression in brain (RPKM 10.1), testis (RPKM 4.8) and 2 other tissues See more
Orthologs
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Genomic context

See FSD1 in Genome Data Viewer
Location:
19p13.3
Exon count:
13
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (4304598..4323836)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (4287878..4307238)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (4304595..4323833)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Src homology 2 domain containing transforming protein D Neighboring gene transmembrane and immunoglobulin domain containing 2 Neighboring gene signal transducing adaptor family member 2 Neighboring gene MPN domain containing Neighboring gene eukaryotic translation initiation factor 1 pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC3213

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in cytoplasmic microtubule organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell division IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cell division IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cytokinesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of mitotic spindle organization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in centrosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in cleavage furrow IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in microtubule IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
fibronectin type III and SPRY domain-containing protein 1
Names
MID1-related protein 1
fibronectin type 3 and SPRY (spla, ryanodine) domain containing (with coiled-coil motif) 1
fibronectin type 3 and SPRY domain containing 1
microtubule-associated protein GLFND
midline 1-related protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330429.2NP_001317358.1  fibronectin type III and SPRY domain-containing protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC008616, CA749067
    Consensus CDS
    CCDS82277.1
    UniProtKB/TrEMBL
    M0R366
    Related
    ENSP00000473022.1, ENST00000597590.5
    Conserved Domains (3) summary
    cd00063
    Location:165265
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl02614
    Location:270402
    SPRY; SPRY domain
    cl25407
    Location:4120
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)
  2. NM_024333.3NP_077309.1  fibronectin type III and SPRY domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_077309.1

    Status: REVIEWED

    Source sequence(s)
    AC008616, BC003124, DA690632
    Consensus CDS
    CCDS12127.1
    UniProtKB/Swiss-Prot
    Q9BTV5, Q9HAG4
    Related
    ENSP00000221856.5, ENST00000221856.11
    Conserved Domains (3) summary
    cd00063
    Location:165265
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12901
    Location:270476
    SPRY_PRY_FSD1; Fibronectin type III and SPRY containing 1 (FSD1) domain includes PRY at the N-terminus
    cl25407
    Location:4120
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    4304598..4323836
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    4287878..4307238
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)