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ZNF576 zinc finger protein 576 [ Homo sapiens (human) ]

Gene ID: 79177, updated on 25-Nov-2025
Official Symbol
ZNF576provided by HGNC
Official Full Name
zinc finger protein 576provided by HGNC
Primary source
HGNC:HGNC:28357
See related
Ensembl:ENSG00000124444 AllianceGenome:HGNC:28357
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in prostate (RPKM 1.5), fat (RPKM 1.4) and 25 other tissues See more
Orthologs
all
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See ZNF576 in Genome Data Viewer
Location:
19q13.31
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (43596392..43601157)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (46418035..46422800)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44100544..44105309)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene X-ray repair cross complementing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10723 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14726 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:44080053-44080579 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:44080580-44081105 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14727 Neighboring gene phospholipase A2 inhibitor and LY6/PLAUR domain containing Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14728 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:44098910-44099706 Neighboring gene immunity related GTPase Q Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14729 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14730 Neighboring gene zinc finger protein 428 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:44123140-44123790 Neighboring gene uncharacterized LOC105372411 Neighboring gene serine/arginine repetitive matrix 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:44127716-44128216 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:44128217-44128717 Neighboring gene cell adhesion molecule 4

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. A GO catalogue of human DNA-binding transcription factors. Lovering RC, et al. Biochim Biophys Acta Gene Regul Mech, 2021 Nov-Dec. PMID 34673265
  2. Basic pH reversed-phase liquid chromatography (bRPLC) in combination with tip-based strong cation exchange (SCX-Tip), ReST, an efficient approach for large-scale cross-linked peptide analysis. Wu Z, et al. Anal Chim Acta, 2021 Sep 22. PMID 34535262
  3. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. Suzuki Y, et al. Genome Res, 2004 Sep. PMID 15342556, Free PMC Article
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Olsen JV, et al. Cell, 2006 Nov 3. PMID 17081983
  5. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. Fragoza R, et al. Nat Commun, 2019 Sep 12. PMID 31515488, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Potential readthrough

Included gene: SRRM5

Homology

Clone Names

  • MGC2508, FLJ22700, FLJ56397

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
zinc finger protein 576

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145347.2 → NP_001138819.1  zinc finger protein 576

    See identical proteins and their annotated locations for NP_001138819.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC006276, BC002981, BP358040
    Consensus CDS
    CCDS12625.1
    UniProtKB/Swiss-Prot
    Q9BU03, Q9H609
    Related
    ENSP00000337852.4, ENST00000336564.5
    Conserved Domains (2) summary
    sd00017
    Location:73 → 93
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:112 → 134
    zf-C2H2; Zinc finger, C2H2 type

  2. NM_024327.2 → NP_077303.1  zinc finger protein 576

    See identical proteins and their annotated locations for NP_077303.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC006276, AK026353
    Consensus CDS
    CCDS12625.1
    UniProtKB/Swiss-Prot
    Q9BU03, Q9H609
    Related
    ENSP00000375827.2, ENST00000391965.6
    Conserved Domains (2) summary
    sd00017
    Location:73 → 93
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:112 → 134
    zf-C2H2; Zinc finger, C2H2 type

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    43596392..43601157
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    46418035..46422800
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H609.1 GenPept UniProtKB/Swiss-Prot:Q9H609

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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