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ZNF576 zinc finger protein 576 [ Homo sapiens (human) ]

Gene ID: 79177, updated on 11-Apr-2024

Summary

Official Symbol
ZNF576provided by HGNC
Official Full Name
zinc finger protein 576provided by HGNC
Primary source
HGNC:HGNC:28357
See related
Ensembl:ENSG00000124444 AllianceGenome:HGNC:28357
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in prostate (RPKM 1.5), fat (RPKM 1.4) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF576 in Genome Data Viewer
Location:
19q13.31
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (43596392..43601157)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (46418035..46422800)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44100544..44105309)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene X-ray repair cross complementing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10723 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14726 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:44080053-44080579 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:44080580-44081105 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14727 Neighboring gene phospholipase A2 inhibitor and LY6/PLAUR domain containing Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14728 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:44098910-44099706 Neighboring gene immunity related GTPase Q Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14729 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14730 Neighboring gene zinc finger protein 428 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:44123140-44123790 Neighboring gene uncharacterized LOC105372411 Neighboring gene serine/arginine repetitive matrix 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:44127716-44128216 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:44128217-44128717 Neighboring gene cell adhesion molecule 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: SRRM5

Clone Names

  • MGC2508, FLJ22700, FLJ56397

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145347.2NP_001138819.1  zinc finger protein 576

    See identical proteins and their annotated locations for NP_001138819.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC006276, BC002981, BP358040
    Consensus CDS
    CCDS12625.1
    UniProtKB/Swiss-Prot
    Q9BU03, Q9H609
    Related
    ENSP00000337852.4, ENST00000336564.5
    Conserved Domains (2) summary
    sd00017
    Location:7393
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:112134
    zf-C2H2; Zinc finger, C2H2 type
  2. NM_024327.2NP_077303.1  zinc finger protein 576

    See identical proteins and their annotated locations for NP_077303.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC006276, AK026353
    Consensus CDS
    CCDS12625.1
    UniProtKB/Swiss-Prot
    Q9BU03, Q9H609
    Related
    ENSP00000375827.2, ENST00000391965.6
    Conserved Domains (2) summary
    sd00017
    Location:7393
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:112134
    zf-C2H2; Zinc finger, C2H2 type

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    43596392..43601157
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    46418035..46422800
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)