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FBXL15 F-box and leucine rich repeat protein 15 [ Homo sapiens (human) ]

Gene ID: 79176, updated on 3-Nov-2019

Summary

Official Symbol
FBXL15provided by HGNC
Official Full Name
F-box and leucine rich repeat protein 15provided by HGNC
Primary source
HGNC:HGNC:28155
See related
Ensembl:ENSG00000107872 MIM:610287
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JET; PSD; Fbl15; FBXO37
Expression
Broad expression in kidney (RPKM 4.8), colon (RPKM 3.6) and 24 other tissues See more
Orthologs

Genomic context

See FBXL15 in Genome Data Viewer
Location:
10q24.32
Exon count:
6
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (102419222..102423138)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (104178979..104182894)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene golgi brefeldin A resistant guanine nucleotide exchange factor 1 Neighboring gene uncharacterized LOC107984263 Neighboring gene nuclear factor kappa B subunit 2 Neighboring gene pleckstrin and Sec7 domain containing Neighboring gene CUE domain containing 2 Neighboring gene microRNA 146b

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
    Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
  • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
    Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16137, MGC11279

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
bone mineralization ISS
Inferred from Sequence or Structural Similarity
more info
 
dorsal/ventral pattern formation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein polyubiquitination TAS
Traceable Author Statement
more info
 
protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
F-box/LRR-repeat protein 15
Names
F-box only protein 37
pleckstrin and Sec7 domain protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024326.3NP_077302.3  F-box/LRR-repeat protein 15

    See identical proteins and their annotated locations for NP_077302.3

    Status: VALIDATED

    Source sequence(s)
    BC002912, BC036120, BI914195
    Consensus CDS
    CCDS31273.1
    UniProtKB/Swiss-Prot
    Q9H469
    Related
    ENSP00000224862.3, ENST00000224862.7
    Conserved Domains (3) summary
    sd00034
    Location:6288
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam00646
    Location:1855
    F-box; F-box domain
    cl28166
    Location:139266
    AMN1; Antagonist of mitotic exit network protein 1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    102419222..102423138
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005270149.2XP_005270206.1  F-box/LRR-repeat protein 15 isoform X1

    Conserved Domains (3) summary
    cd09293
    Location:226353
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:149175
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam00646
    Location:105142
    F-box; F-box domain
  2. XM_005270151.3XP_005270208.1  F-box/LRR-repeat protein 15 isoform X2

    See identical proteins and their annotated locations for XP_005270208.1

    UniProtKB/Swiss-Prot
    Q9H469
    Conserved Domains (3) summary
    sd00034
    Location:6288
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam00646
    Location:1855
    F-box; F-box domain
    cl28166
    Location:139266
    AMN1; Antagonist of mitotic exit network protein 1
  3. XM_005270150.5XP_005270207.1  F-box/LRR-repeat protein 15 isoform X2

    See identical proteins and their annotated locations for XP_005270207.1

    UniProtKB/Swiss-Prot
    Q9H469
    Conserved Domains (3) summary
    sd00034
    Location:6288
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam00646
    Location:1855
    F-box; F-box domain
    cl28166
    Location:139266
    AMN1; Antagonist of mitotic exit network protein 1
  4. XM_017016631.1XP_016872120.1  F-box/LRR-repeat protein 15 isoform X2

    UniProtKB/Swiss-Prot
    Q9H469
    Conserved Domains (3) summary
    sd00034
    Location:6288
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam00646
    Location:1855
    F-box; F-box domain
    cl28166
    Location:139266
    AMN1; Antagonist of mitotic exit network protein 1
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