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FBXL15 F-box and leucine rich repeat protein 15 [ Homo sapiens (human) ]

Gene ID: 79176, updated on 5-Aug-2022

Summary

Official Symbol
FBXL15provided by HGNC
Official Full Name
F-box and leucine rich repeat protein 15provided by HGNC
Primary source
HGNC:HGNC:28155
See related
Ensembl:ENSG00000107872 MIM:610287; AllianceGenome:HGNC:28155
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JET; PSD; Fbl15; FBXO37
Summary
Involved in G2/M transition of mitotic cell cycle; cellular protein metabolic process; and positive regulation of BMP signaling pathway. Located in cytoplasm. Part of SCF ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney (RPKM 4.8), colon (RPKM 3.6) and 24 other tissues See more
Orthologs
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Genomic context

See FBXL15 in Genome Data Viewer
Location:
10q24.32
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (102420836..102423136)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (103305800..103308100)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (104180593..104182893)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 13585 Neighboring gene nuclear factor kappa B subunit 2 Neighboring gene Sharpr-MPRA regulatory region 3575 Neighboring gene pleckstrin and Sec7 domain containing Neighboring gene CUE domain containing 2 Neighboring gene microRNA 146b

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16137, MGC11279

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
F-box/LRR-repeat protein 15
Names
F-box only protein 37
pleckstrin and Sec7 domain protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001387294.1NP_001374223.1  F-box/LRR-repeat protein 15

    Status: VALIDATED

    Source sequence(s)
    AL121928
    UniProtKB/Swiss-Prot
    Q5JWA5
    Conserved Domains (3) summary
    cd09293
    Location:139266
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:6288
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam00646
    Location:1855
    F-box; F-box domain
  2. NM_024326.4NP_077302.3  F-box/LRR-repeat protein 15

    See identical proteins and their annotated locations for NP_077302.3

    Status: VALIDATED

    Source sequence(s)
    AL121928
    Consensus CDS
    CCDS31273.1
    UniProtKB/Swiss-Prot
    Q5JWA5, Q9H469
    Related
    ENSP00000358972.3, ENST00000369956.8
    Conserved Domains (3) summary
    cd09293
    Location:139266
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:6288
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam00646
    Location:1855
    F-box; F-box domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    102420836..102423136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    103305800..103308100
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)