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CENPO centromere protein O [ Homo sapiens (human) ]

Gene ID: 79172, updated on 17-Jun-2019

Summary

Official Symbol
CENPOprovided by HGNC
Official Full Name
centromere protein Oprovided by HGNC
Primary source
HGNC:HGNC:28152
See related
Ensembl:ENSG00000138092 MIM:611504
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CENP-O; MCM21R; ICEN-36
Summary
This gene encodes a component of the interphase centromere complex. The encoded protein is localized to the centromere throughout the cell cycle and is required for bipolar spindle assembly, chromosome segregation and checkpoint signaling during mitosis. Alternatively spliced transcript variants encoding multiple protein isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Expression
Ubiquitous expression in placenta (RPKM 11.4), testis (RPKM 8.5) and 24 other tissues See more
Orthologs

Genomic context

See CENPO in Genome Data Viewer
Location:
2p23.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (24793115..24822376)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (25016175..25045245)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene nuclear receptor coactivator 1 Neighboring gene RNA, U6 small nuclear 936, pseudogene Neighboring gene uncharacterized LOC105369164 Neighboring gene peptidyl-tRNA hydrolase domain containing 1 Neighboring gene uncharacterized LOC105377626 Neighboring gene adenylate cyclase 3 Neighboring gene DnaJ heat shock protein family (Hsp40) member C27 Neighboring gene ribosomal protein S13 pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.
NHGRI GWA Catalog
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
NHGRI GWA Catalog

Pathways from BioSystems

  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • Chromosome Maintenance, organism-specific biosystem (from REACTOME)
    Chromosome Maintenance, organism-specific biosystemChromosome maintenance is critical for stable chromosome function in mammalian and other eukaryotic cells. Aspects of telomere maintenance and nucleosome assembly are covered here.
  • Deposition of new CENPA-containing nucleosomes at the centromere, organism-specific biosystem (from REACTOME)
    Deposition of new CENPA-containing nucleosomes at the centromere, organism-specific biosystemEukaryotic centromeres are marked by a unique form of histone H3, designated CENPA in humans. In human cells newly synthesized CENPA is deposited in nucleosomes at the centromere during late telophas...
  • M Phase, organism-specific biosystem (from REACTOME)
    M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
  • Mitotic Anaphase, organism-specific biosystem (from REACTOME)
    Mitotic Anaphase, organism-specific biosystemIn anaphase, the paired chromosomes separate at the centromeres, and move to the opposite sides of the cell. The movement of the chromosomes is facilitated by a combination of kinetochore movement al...
  • Mitotic Metaphase and Anaphase, organism-specific biosystem (from REACTOME)
    Mitotic Metaphase and Anaphase, organism-specific biosystemMetaphase is marked by the formation of the metaphase plate. The metaphase plate is formed when the spindle fibers align the chromosomes along the middle of the cell. Such an organization helps to ...
  • Mitotic Prometaphase, organism-specific biosystem (from REACTOME)
    Mitotic Prometaphase, organism-specific biosystemThe dissolution of the nuclear membrane marks the beginning of the prometaphase. Kinetochores are created when proteins attach to the centromeres. Microtubules then attach at the kinetochores, and th...
  • Nucleosome assembly, organism-specific biosystem (from REACTOME)
    Nucleosome assembly, organism-specific biosystemThe formation of centromeric chromatin assembly outside the context of DNA replication involves the assembly of nucleosomes containing the histone H3 variant CenH3 (also called CENP-A).
  • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
    RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
  • RHO GTPases Activate Formins, organism-specific biosystem (from REACTOME)
    RHO GTPases Activate Formins, organism-specific biosystemFormins are a family of proteins with 15 members in mammals, organized into 8 subfamilies. Formins are involved in the regulation of actin cytoskeleton. Many but not all formin family members are act...
  • Resolution of Sister Chromatid Cohesion, organism-specific biosystem (from REACTOME)
    Resolution of Sister Chromatid Cohesion, organism-specific biosystemThe resolution of sister chromatids in mitotic prometaphase involves removal of cohesin complexes from chromosomal arms, with preservation of cohesion at centromeres (Losada et al. 1998, Hauf et al. ...
  • Separation of Sister Chromatids, organism-specific biosystem (from REACTOME)
    Separation of Sister Chromatids, organism-specific biosystemWhile sister chromatids resolve in prometaphase, separating along chromosomal arms, the cohesion of sister centromeres persists until anaphase. At the anaphase onset, the anaphase promoting complex/c...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC11266

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
CENP-A containing nucleosome assembly TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Mis6-Sim4 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
condensed nuclear chromosome kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
centromere protein O
Names
centromeric protein O
interphase centromere complex protein 36

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199803.3NP_001186732.1  centromere protein O isoform 2

    See identical proteins and their annotated locations for NP_001186732.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks an exon in the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC012073, AK027859, BX110829
    Consensus CDS
    CCDS56113.1
    UniProtKB/Swiss-Prot
    Q9BU64
    Related
    ENSP00000417787.1, ENST00000473706.5
    Conserved Domains (1) summary
    pfam09496
    Location:140163
    CENP-O; Cenp-O kinetochore centromere component
  2. NM_001322101.2NP_001309030.1  centromere protein O isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) and variant 1 both encode isoform 1.
    Source sequence(s)
    AC012073, AK027859, BX110829, BX406097, CF993857
    Consensus CDS
    CCDS1714.1
    UniProtKB/Swiss-Prot
    Q9BU64
    Related
    ENSP00000370214.2, ENST00000380834.7
    Conserved Domains (1) summary
    pfam09496
    Location:146169
    CENP-O; Cenp-O kinetochore centromere component
  3. NM_024322.3NP_077298.1  centromere protein O isoform 1

    See identical proteins and their annotated locations for NP_077298.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1 and 3 both encode isoform 1.
    Source sequence(s)
    AC012073, BC002870, BX110829, CF993857
    Consensus CDS
    CCDS1714.1
    UniProtKB/Swiss-Prot
    Q9BU64
    Related
    ENSP00000260662.1, ENST00000260662.2
    Conserved Domains (1) summary
    pfam09496
    Location:146169
    CENP-O; Cenp-O kinetochore centromere component

RNA

  1. NR_136182.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC012073, AK027859, BX110829, CF993857, CN263048, CX872478
  2. NR_136183.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC012073, AK027859, BX110829, CF993857, CN263048
  3. NR_136184.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC012073, AK027859, BX110829, CF993857, CX872478

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    24793115..24822376
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_244957.2 RNA Sequence

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