NOL12 nucleolar protein 12 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NOL12provided by HGNC
Official Full Name: nucleolar protein 12provided by HGNC
Primary source: HGNC:HGNC:28585
See related: Ensembl:ENSG00000273899 MIM:621385; AllianceGenome:HGNC:28585
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: VITO; Nop25; dJ37E16.7
Summary: Enables identical protein binding activity. Predicted to be located in cytoplasm and nucleus. Predicted to be active in nucleolus. [provided by Alliance of Genome Resources, Jul 2025]
Expression: Ubiquitous expression in testis (RPKM 6.5), skin (RPKM 5.0) and 25 other tissues See more
Orthologs: all
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Genomic context

Location:: 22q13.1

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	22	NC_000022.11 (37686343..37693474)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	22	NC_060946.1 (38147595..38154723)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	22	NC_000022.10 (38082350..38089481)

Chromosome 22 - NC_000022.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The human cellular protein NoL12 is a specific partner of the HIV-1 nucleocapsid protein NCp7.
Title: The human cellular protein NoL12 is a specific partner of the HIV-1 nucleocapsid protein NCp7.
Results show that NOL12 is important for nucleolar homeostasis, regulating its structure and the nucleolar levels of the multifunctional fibrillarin and nucleolin proteins. Moreover, NOL12 depletion to induce strong p53 activation leading to cell senescence suggesting an important role for NOL12 in replicative and chronological aging and its potential as aging biomarker.
Title: NOL12 Repression Induces Nucleolar Stress-Driven Cellular Senescence and Is Associated with Normative Aging.
Nol12 is an RNA binding protein required for both ribosome maturation and genome integrity
Title: Nol12 is a multifunctional RNA binding protein at the nexus of RNA and DNA metabolism.
Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interaction	Pubs
Knockdown of nucleolar protein 12 (NOL12) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells	PubMed

Protein	Gene	Interaction	Pubs
nucleocapsid	gag	HIV-1 NC is identified to have a physical interaction with nucleolar protein 12 (NOL12) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-AA029910 (e-PCR)
- UniSTS:63804

MARC_6377-6378:997299596:1 (e-PCR)
- UniSTS:269652

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables rRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables rRNA binding	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nucleolar protein 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.