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NOL12 nucleolar protein 12 [ Homo sapiens (human) ]

Gene ID: 79159, updated on 17-Jun-2024

Summary

Official Symbol
NOL12provided by HGNC
Official Full Name
nucleolar protein 12provided by HGNC
Primary source
HGNC:HGNC:28585
See related
Ensembl:ENSG00000273899 AllianceGenome:HGNC:28585
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Nop25; dJ37E16.7
Summary
Enables identical protein binding activity. Predicted to be active in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 6.5), skin (RPKM 5.0) and 25 other tissues See more
Orthologs
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Genomic context

See NOL12 in Genome Data Viewer
Location:
22q13.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (37686343..37693474)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (38147595..38154723)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (38082350..38089481)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 385, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13693 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38073459-38074269 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38077520-38078020 Neighboring gene galectin 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:38081369-38082310 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:38082311-38083251 Neighboring gene TRIO and F-actin binding protein Neighboring gene ReSE screen-validated silencer GRCh37_chr22:38108187-38108370 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38121829-38122330 Neighboring gene uncharacterized LOC124905115 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38136652-38137169 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38137170-38137686 Neighboring gene uncharacterized LOC102724378 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13695 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13696 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13697 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr22:38147547-38148746 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr22:38150829-38152028 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:38153498-38153662 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38158448-38158948 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38177743-38178242 Neighboring gene small nucleolar RNA U13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of nucleolar protein 12 (NOL12) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
nucleocapsid gag HIV-1 NC is identified to have a physical interaction with nucleolar protein 12 (NOL12) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: TRIOBP

Clone Names

  • MGC3731, FLJ34609

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables rRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables single-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024313.3NP_077289.1  nucleolar protein 12

    See identical proteins and their annotated locations for NP_077289.1

    Status: VALIDATED

    Source sequence(s)
    BC002808, BE241845, Z83844
    Consensus CDS
    CCDS13955.1
    UniProtKB/Swiss-Prot
    Q9UGY1
    UniProtKB/TrEMBL
    B3KQ09
    Related
    ENSP00000352021.4, ENST00000359114.9
    Conserved Domains (1) summary
    pfam09805
    Location:2067
    Nop25; Nucleolar protein 12 (25kDa)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    37686343..37693474
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    38147595..38154723
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)