Format

Send to:

Choose Destination

MFSD11 major facilitator superfamily domain containing 11 [ Homo sapiens (human) ]

Gene ID: 79157, updated on 23-Nov-2021

Summary

Official Symbol
MFSD11provided by HGNC
Official Full Name
major facilitator superfamily domain containing 11provided by HGNC
Primary source
HGNC:HGNC:25458
See related
Ensembl:ENSG00000092931
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ET
Expression
Ubiquitous expression in colon (RPKM 5.3), stomach (RPKM 4.4) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See MFSD11 in Genome Data Viewer
Location:
17q25.1-q25.2
Exon count:
21
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (76736634..76803805)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (74732716..74775423)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene jumonji domain containing 6, arginine demethylase and lysine hydroxylase Neighboring gene methyltransferase like 23 Neighboring gene serine and arginine rich splicing factor 2 Neighboring gene microRNA 636 Neighboring gene RNA, U6 small nuclear 97, pseudogene Neighboring gene long intergenic non-protein coding RNA 2080 Neighboring gene uncharacterized LOC107985089 Neighboring gene long intergenic non-protein coding RNA 868

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20226, FLJ22196

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
UNC93-like protein MFSD11
Names
major facilitator superfamily domain-containing protein 11
protein ET

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242532.5NP_001229461.1  UNC93-like protein MFSD11 isoform 1

    See identical proteins and their annotated locations for NP_001229461.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Variants 1-5 and 8-10 encode the same protein (isoform 1).
    Source sequence(s)
    AC005837, AC027694
    Consensus CDS
    CCDS11750.1
    UniProtKB/Swiss-Prot
    O43934
    UniProtKB/TrEMBL
    A0A024R8U7
    Related
    ENSP00000464932.1, ENST00000588460.5
    Conserved Domains (1) summary
    pfam05978
    Location:14166
    UNC-93; Ion channel regulatory protein UNC-93
  2. NM_001242533.3NP_001229462.1  UNC93-like protein MFSD11 isoform 1

    See identical proteins and their annotated locations for NP_001229462.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1-5 and 8-10 encode the same protein (isoform 1).
    Source sequence(s)
    AC005837, AC027694
    Consensus CDS
    CCDS11750.1
    UniProtKB/Swiss-Prot
    O43934
    UniProtKB/TrEMBL
    A0A024R8U7
    Related
    ENSP00000468309.1, ENST00000590514.5
    Conserved Domains (1) summary
    pfam05978
    Location:14166
    UNC-93; Ion channel regulatory protein UNC-93
  3. NM_001242534.3NP_001229463.1  UNC93-like protein MFSD11 isoform 1

    See identical proteins and their annotated locations for NP_001229463.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1-5 and 8-10 encode the same protein (isoform 1).
    Source sequence(s)
    AC005837, AC027694
    Consensus CDS
    CCDS11750.1
    UniProtKB/Swiss-Prot
    O43934
    UniProtKB/TrEMBL
    A0A024R8U7
    Related
    ENSP00000485005.1, ENST00000621483.4
    Conserved Domains (1) summary
    pfam05978
    Location:14166
    UNC-93; Ion channel regulatory protein UNC-93
  4. NM_001242535.3NP_001229464.1  UNC93-like protein MFSD11 isoform 1

    See identical proteins and their annotated locations for NP_001229464.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1-5 and 8-10 encode the same protein (isoform 1).
    Source sequence(s)
    AC005837, AC027694
    Consensus CDS
    CCDS11750.1
    UniProtKB/Swiss-Prot
    O43934
    UniProtKB/TrEMBL
    A0A024R8U7
    Conserved Domains (1) summary
    pfam05978
    Location:14166
    UNC-93; Ion channel regulatory protein UNC-93
  5. NM_001242536.3NP_001229465.1  UNC93-like protein MFSD11 isoform 2

    See identical proteins and their annotated locations for NP_001229465.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and lacks two in-frame exons in the 5' coding region, compared to variant 1. This variant encodes a shorter protein (isoform 2), compared to isoform 1. Variants 6 and 7 encode the same protein (isoform 2).
    Source sequence(s)
    AC005837, AC027694
    Consensus CDS
    CCDS56045.1
    UniProtKB/Swiss-Prot
    O43934
    UniProtKB/TrEMBL
    A0A024R8M6
    Related
    ENSP00000348225.3, ENST00000355954.7
    Conserved Domains (1) summary
    cl21472
    Location:14113
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  6. NM_001242537.3NP_001229466.1  UNC93-like protein MFSD11 isoform 2

    See identical proteins and their annotated locations for NP_001229466.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and lacks two in-frame exons in the 5' coding region, compared to variant 1. This variant encodes a shorter protein (isoform 2), compared to isoform 1. Variants 6 and 7 encode the same protein (isoform 2).
    Source sequence(s)
    AC005837, AC027694
    Consensus CDS
    CCDS56045.1
    UniProtKB/Swiss-Prot
    O43934
    UniProtKB/TrEMBL
    A0A024R8M6
    Related
    ENSP00000466782.1, ENST00000593181.5
    Conserved Domains (1) summary
    cl21472
    Location:14113
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  7. NM_001353017.2NP_001339946.1  UNC93-like protein MFSD11 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1-5 and 8-10 encode the same protein (isoform 1).
    Source sequence(s)
    AC005837, AC027694
    Consensus CDS
    CCDS11750.1
    Conserved Domains (1) summary
    pfam05978
    Location:14166
    UNC-93; Ion channel regulatory protein UNC-93
  8. NM_001353018.2NP_001339947.1  UNC93-like protein MFSD11 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1-5 and 8-10 encode the same protein (isoform 1).
    Source sequence(s)
    AC005837, AC027694
    Consensus CDS
    CCDS11750.1
    Conserved Domains (1) summary
    pfam05978
    Location:14166
    UNC-93; Ion channel regulatory protein UNC-93
  9. NM_001353019.2NP_001339948.1  UNC93-like protein MFSD11 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1-5 and 8-10 encode the same protein (isoform 1).
    Source sequence(s)
    AC005837, AC027694
    Consensus CDS
    CCDS11750.1
    Conserved Domains (1) summary
    pfam05978
    Location:14166
    UNC-93; Ion channel regulatory protein UNC-93
  10. NM_024311.5NP_077287.1  UNC93-like protein MFSD11 isoform 1

    See identical proteins and their annotated locations for NP_077287.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1-5 and 8-10 encode the same protein (isoform 1).
    Source sequence(s)
    AC005837, AC027694
    Consensus CDS
    CCDS11750.1
    UniProtKB/Swiss-Prot
    O43934
    UniProtKB/TrEMBL
    A0A024R8U7
    Related
    ENSP00000337240.3, ENST00000336509.8
    Conserved Domains (1) summary
    pfam05978
    Location:14166
    UNC-93; Ion channel regulatory protein UNC-93

RNA

  1. NR_148229.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005837, AC027694
  2. NR_148230.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005837, AC027694
  3. NR_148231.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005837, AC027694
  4. NR_148232.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005837, AC027694
  5. NR_148233.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005837, AC027694
  6. NR_148234.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005837, AC027694
  7. NR_148235.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (17) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005837, AC027694
  8. NR_148236.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (18) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005837, AC027694
  9. NR_148237.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (19) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005837, AC027694
  10. NR_148238.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (20) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005837, AC027694
  11. NR_148239.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (21) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005837, AC027694
  12. NR_148240.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (22) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005837, AC027694
  13. NR_148242.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (23) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005837, AC027694

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    76736634..76803805
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525238.3XP_011523540.2  UNC93-like protein MFSD11 isoform X1

    Conserved Domains (1) summary
    pfam05978
    Location:14166
    UNC-93; Ion channel regulatory protein UNC-93
  2. XM_011525239.3XP_011523541.2  UNC93-like protein MFSD11 isoform X1

    Conserved Domains (1) summary
    pfam05978
    Location:14166
    UNC-93; Ion channel regulatory protein UNC-93
  3. XM_017025065.2XP_016880554.1  UNC93-like protein MFSD11 isoform X1

    Conserved Domains (1) summary
    pfam05978
    Location:14166
    UNC-93; Ion channel regulatory protein UNC-93
  4. XM_011525241.3XP_011523543.2  UNC93-like protein MFSD11 isoform X1

    Conserved Domains (1) summary
    pfam05978
    Location:14166
    UNC-93; Ion channel regulatory protein UNC-93
  5. XM_011525240.3XP_011523542.2  UNC93-like protein MFSD11 isoform X1

    Conserved Domains (1) summary
    pfam05978
    Location:14166
    UNC-93; Ion channel regulatory protein UNC-93
  6. XM_011525247.2XP_011523549.2  UNC93-like protein MFSD11 isoform X4

  7. XM_024450946.1XP_024306714.1  UNC93-like protein MFSD11 isoform X6

  8. XM_011525237.3XP_011523539.2  UNC93-like protein MFSD11 isoform X1

    Conserved Domains (1) summary
    pfam05978
    Location:14166
    UNC-93; Ion channel regulatory protein UNC-93
  9. XM_011525242.2XP_011523544.1  UNC93-like protein MFSD11 isoform X3

    See identical proteins and their annotated locations for XP_011523544.1

    Conserved Domains (1) summary
    pfam05978
    Location:14166
    UNC-93; Ion channel regulatory protein UNC-93
  10. XM_011525244.2XP_011523546.1  UNC93-like protein MFSD11 isoform X5

    See identical proteins and their annotated locations for XP_011523546.1

    Conserved Domains (1) summary
    pfam05978
    Location:14166
    UNC-93; Ion channel regulatory protein UNC-93
  11. XM_024450944.1XP_024306712.1  UNC93-like protein MFSD11 isoform X1

    Conserved Domains (1) summary
    pfam05978
    Location:14166
    UNC-93; Ion channel regulatory protein UNC-93
  12. XM_011525236.3XP_011523538.1  UNC93-like protein MFSD11 isoform X2

    See identical proteins and their annotated locations for XP_011523538.1

    Conserved Domains (1) summary
    pfam05978
    Location:14166
    UNC-93; Ion channel regulatory protein UNC-93
Support Center