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TNIP2 TNFAIP3 interacting protein 2 [ Homo sapiens (human) ]

Gene ID: 79155, updated on 1-Jun-2020

Summary

Official Symbol
TNIP2provided by HGNC
Official Full Name
TNFAIP3 interacting protein 2provided by HGNC
Primary source
HGNC:HGNC:19118
See related
Ensembl:ENSG00000168884 MIM:610669
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KLIP; ABIN2; FLIP1
Summary
This gene encodes a protein which acts as an inhibitor of NFkappaB activation. The encoded protein is also involved in MAP/ERK signaling pathway in specific cell types. It may be involved in apoptosis of endothelial cells. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the X chromosome.[provided by RefSeq, May 2014]
Expression
Ubiquitous expression in small intestine (RPKM 12.1), colon (RPKM 11.5) and 25 other tissues See more
Orthologs

Genomic context

See TNIP2 in Genome Data Viewer
Location:
4p16.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (2741648..2756336, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (2743387..2758103, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ring finger protein 4 Neighboring gene family with sequence similarity 193 member A Neighboring gene uncharacterized LOC102723763 Neighboring gene nonconserved acetylation island sequence 125 enhancer Neighboring gene SH3 domain binding protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC4289, DKFZp434J1313

Gene Ontology Provided by GOA

Function Evidence Code Pubs
K63-linked polyubiquitin modification-dependent protein binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
polyubiquitin modification-dependent protein binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
CD40 signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
I-kappaB kinase/NF-kappaB signaling IEA
Inferred from Electronic Annotation
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cellular response to lipopolysaccharide ISS
Inferred from Sequence or Structural Similarity
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
interleukin-1-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
interleukin-1-mediated signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of endothelial cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of B cell activation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of macrophage activation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
protein deubiquitination TAS
Traceable Author Statement
more info
 
protein stabilization ISS
Inferred from Sequence or Structural Similarity
more info
 
stress-activated MAPK cascade TAS
Traceable Author Statement
more info
 
toll-like receptor 2 signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
toll-like receptor 2 signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
toll-like receptor 3 signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
toll-like receptor 3 signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
toll-like receptor 9 signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
TNFAIP3-interacting protein 2
Names
A20-binding inhibitor of NF-kappaB activation-2
fetal liver LKB1-interacting protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161527.2NP_001154999.1  TNFAIP3-interacting protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK026176, AL110117, AL121750, BC002740, DA421921
    Consensus CDS
    CCDS54714.1
    UniProtKB/Swiss-Prot
    Q8NFZ5
    Related
    ENSP00000427613.1, ENST00000510267.5
    Conserved Domains (2) summary
    pfam12180
    Location:107139
    EABR; TSG101 and ALIX binding domain of CEP55
    cl15254
    Location:151232
    UBAN; polyubiquitin binding domain of NEMO and related proteins
  2. NM_001292016.2NP_001278945.1  TNFAIP3-interacting protein 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 3, which lacks an internal segment and is shorter than isoform 1.
    Source sequence(s)
    AF372839, AL110117, BC002740, BX386180, CB157550
    Consensus CDS
    CCDS75093.1
    UniProtKB/Swiss-Prot
    Q8NFZ5
    UniProtKB/TrEMBL
    D6RGJ2
    Related
    ENSP00000426314.1, ENST00000503235.1
    Conserved Domains (1) summary
    COG1196
    Location:20251
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  3. NM_024309.4NP_077285.3  TNFAIP3-interacting protein 2 isoform 1

    See identical proteins and their annotated locations for NP_077285.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF372839, AL110117, BC002740
    Consensus CDS
    CCDS3362.1
    UniProtKB/Swiss-Prot
    Q8NFZ5
    Related
    ENSP00000321203.7, ENST00000315423.12
    Conserved Domains (2) summary
    pfam12180
    Location:214246
    EABR; TSG101 and ALIX binding domain of CEP55
    cl15254
    Location:258339
    UBAN; polyubiquitin binding domain of NEMO and related proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    2741648..2756336 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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