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DHRS11 dehydrogenase/reductase 11 [ Homo sapiens (human) ]

Gene ID: 79154, updated on 9-Sep-2025
Official Symbol
DHRS11provided by HGNC
Official Full Name
dehydrogenase/reductase 11provided by HGNC
Primary source
HGNC:HGNC:28639
See related
Ensembl:ENSG00000278535 MIM:616159; AllianceGenome:HGNC:28639
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARPG836; SDR24C1; spDHRS11
Summary
Enables 17-beta-hydroxysteroid dehydrogenase (NADP+) activity; 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity; and estradiol 17-beta-dehydrogenase [NAD(P)+] activity. Involved in steroid biosynthetic process. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in duodenum (RPKM 115.7), small intestine (RPKM 99.1) and 4 other tissues See more
Orthologs
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See DHRS11 in Genome Data Viewer
Location:
17q12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (36591879..36600804)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (37578223..37587148)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (34948309..34957233)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene myosin XIX Neighboring gene phosphatidylinositol glycan anchor biosynthesis class W Neighboring gene gametogenetin binding protein 2 Neighboring gene ribosomal protein S2 pseudogene 50 Neighboring gene uncharacterized LOC107985031 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:34983260-34983760 Neighboring gene mitochondrial rRNA methyltransferase 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:34998295-34999169 Neighboring gene MPRA-validated peak2825 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35010359-35010858 Neighboring gene VISTA enhancer hs362 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:35013913-35014450 Neighboring gene uncharacterized LOC105371750 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:35018784-35018989 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35021739-35022238 Neighboring gene uncharacterized LOC105371751

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Human dehydrogenase/reductase SDR family member 11 (DHRS11) and aldo-keto reductase 1C isoforms in comparison: Substrate and reaction specificity in the reduction of 11-keto-C(19)-steroids. Endo S, et al. J Steroid Biochem Mol Biol, 2020 May. PMID 31926269
  2. Human dehydrogenase/reductase (SDR family) member 11 is a novel type of 17β-hydroxysteroid dehydrogenase. Endo S, et al. Biochem Biophys Res Commun, 2016 Mar 25. PMID 26920053
  3. Elevation of hsa-miR-7-5p level mediated by CtBP1-p300-AP1 complex targets ATXN1 to trigger NF-κB-dependent inflammation response. Lou LQ, et al. J Mol Med (Berl), 2023 Mar. PMID 36629882
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article
  5. Panorama of ancient metazoan macromolecular complexes. Wan C, et al. Nature, 2015 Sep 17. PMID 26344197, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Human dehydrogenase/reductase SDR family member 11 (DHRS11) and aldo-keto reductase 1C isoforms in comparison: Substrate and reaction specificity in the reduction of 11-keto-C19-steroids.
    Title: Human dehydrogenase/reductase SDR family member 11 (DHRS11) and aldo-keto reductase 1C isoforms in comparison: Substrate and reaction specificity in the reduction of 11-keto-C(19)-steroids.
  2. The recombinant protein (DHRS11) efficiently catalyzed the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5alpha-androstanes into their 17beta-hydroxyl metabolites with NADPH as a coenzyme.
    Title: Human dehydrogenase/reductase (SDR family) member 11 is a novel type of 17β-hydroxysteroid dehydrogenase.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC4172, FLJ39232

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 17-beta-hydroxysteroid dehydrogenase (NADP+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
  
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in estrogen biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in steroid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in steroid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
dehydrogenase/reductase SDR family member 11
Names
17-beta-hydroxysteroid dehydrogenase
3-beta-hydroxysteroid 3-dehydrogenase
dehydrogenase/reductase (SDR family) member 11
estradiol 17-beta-dehydrogenase
short-chain dehydrogenase/reductase family 24C member 1
NP_077284.2
XP_005257715.1
XP_011523535.1
XP_047292688.1
XP_054173159.1
XP_054173160.1
XP_054173161.1
XP_054185307.1
XP_054185308.1
XP_054185309.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024308.4 → NP_077284.2  dehydrogenase/reductase SDR family member 11 precursor

    See identical proteins and their annotated locations for NP_077284.2

    Status: VALIDATED

    Source sequence(s)
    AY358712, BG037061
    Consensus CDS
    CCDS11315.2
    UniProtKB/Swiss-Prot
    A0A0U5BLD0, B2RDZ3, Q6UWP2, Q9BUC7, Q9H674
    Related
    ENSP00000482704.1, ENST00000618403.5
    Conserved Domains (1) summary
    cd05343
    Location:6 → 256
    Mgc4172-like_SDR_c; human Mgc4172-like, classical (c) SDRs

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    36591879..36600804
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257658.4 → XP_005257715.1  dehydrogenase/reductase SDR family member 11 isoform X1

    See identical proteins and their annotated locations for XP_005257715.1

    UniProtKB/Swiss-Prot
    Q6UWP2
    Related
    ENSP00000621402.1, ENST00000951343.1
    Conserved Domains (1) summary
    cd05343
    Location:6 → 225
    Mgc4172-like_SDR_c; human Mgc4172-like, classical (c) SDRs

  2. XM_011525233.3 → XP_011523535.1  dehydrogenase/reductase SDR family member 11 isoform X2

    See identical proteins and their annotated locations for XP_011523535.1

    Related
    ENSP00000522332.1, ENST00000852273.1
    Conserved Domains (2) summary
    COG4221
    Location:6 → 189
    YdfG; NADP-dependent 3-hydroxy acid dehydrogenase YdfG [Energy production and conversion]
    cl21454
    Location:6 → 186
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  3. XM_047436732.1 → XP_047292688.1  dehydrogenase/reductase SDR family member 11 isoform X3

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    827374..836298
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329332.1 → XP_054185307.1  dehydrogenase/reductase SDR family member 11 isoform X1

  2. XM_054329333.1 → XP_054185308.1  dehydrogenase/reductase SDR family member 11 isoform X2

  3. XM_054329334.1 → XP_054185309.1  dehydrogenase/reductase SDR family member 11 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    37578223..37587148
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054317184.1 → XP_054173159.1  dehydrogenase/reductase SDR family member 11 isoform X1

  2. XM_054317185.1 → XP_054173160.1  dehydrogenase/reductase SDR family member 11 isoform X2

  3. XM_054317186.1 → XP_054173161.1  dehydrogenase/reductase SDR family member 11 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6UWP2.1 GenPept UniProtKB/Swiss-Prot:Q6UWP2

Gene LinkOut

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