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DHRS11 dehydrogenase/reductase 11 [ Homo sapiens (human) ]

Gene ID: 79154, updated on 13-Mar-2020

Summary

Official Symbol
DHRS11provided by HGNC
Official Full Name
dehydrogenase/reductase 11provided by HGNC
Primary source
HGNC:HGNC:28639
See related
Ensembl:ENSG00000278535 MIM:616159
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARPG836; SDR24C1; spDHRS11
Expression
Biased expression in duodenum (RPKM 115.7), small intestine (RPKM 99.1) and 4 other tissues See more
Orthologs

Genomic context

See DHRS11 in Genome Data Viewer
Location:
17q12
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (36591846..36600804)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (34948226..34957233)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene myosin XIX Neighboring gene phosphatidylinositol glycan anchor biosynthesis class W Neighboring gene gametogenetin binding protein 2 Neighboring gene ribosomal protein S2 pseudogene 50 Neighboring gene uncharacterized LOC107985031 Neighboring gene mitochondrial rRNA methyltransferase 1 Neighboring gene VISTA enhancer hs362

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC4172, FLJ39232

Gene Ontology Provided by GOA

Function Evidence Code Pubs
17-beta-hydroxysteroid dehydrogenase (NADP+) activity IDA
Inferred from Direct Assay
more info
PubMed 
17-beta-ketosteroid reductase activity IDA
Inferred from Direct Assay
more info
PubMed 
3-keto sterol reductase activity IDA
Inferred from Direct Assay
more info
PubMed 
estradiol 17-beta-dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
estrogen biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
steroid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dehydrogenase/reductase SDR family member 11
Names
17-beta-hydroxysteroid dehydrogenase
3-beta-hydroxysteroid 3-dehydrogenase
dehydrogenase/reductase (SDR family) member 11
estradiol 17-beta-dehydrogenase
inactive dehydrogenase/reductase isoform
short-chain dehydrogenase/reductase family 24C member 1
NP_077284.2
XP_005257715.1
XP_011523535.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024308.4NP_077284.2  dehydrogenase/reductase SDR family member 11 precursor

    See identical proteins and their annotated locations for NP_077284.2

    Status: VALIDATED

    Source sequence(s)
    AY358712, BG037061
    Consensus CDS
    CCDS11315.2
    UniProtKB/Swiss-Prot
    Q6UWP2
    UniProtKB/TrEMBL
    A0A024R0T1
    Related
    ENSP00000482704.1, ENST00000618403.5
    Conserved Domains (2) summary
    cd05343
    Location:6256
    Mgc4172-like_SDR_c; human Mgc4172-like, classical (c) SDRs
    COG4221
    Location:6259
    YdfG; NADP-dependent 3-hydroxy acid dehydrogenase YdfG [Energy production and conversion]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    36591846..36600804
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525233.2XP_011523535.1  dehydrogenase/reductase SDR family member 11 isoform X2

    See identical proteins and their annotated locations for XP_011523535.1

    Conserved Domains (2) summary
    COG4221
    Location:6189
    YdfG; NADP-dependent 3-hydroxy acid dehydrogenase YdfG [Energy production and conversion]
    cl21454
    Location:6186
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. XM_005257658.3XP_005257715.1  dehydrogenase/reductase SDR family member 11 isoform X1

    See identical proteins and their annotated locations for XP_005257715.1

    UniProtKB/Swiss-Prot
    Q6UWP2
    Conserved Domains (2) summary
    cd05343
    Location:6225
    Mgc4172-like_SDR_c; human Mgc4172-like, classical (c) SDRs
    COG4221
    Location:6228
    YdfG; NADP-dependent 3-hydroxy acid dehydrogenase YdfG [Energy production and conversion]

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    827374..836298
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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