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RETREG2 reticulophagy regulator family member 2 [ Homo sapiens (human) ]

Gene ID: 79137, updated on 22-Sep-2022

Summary

Official Symbol
RETREG2provided by HGNC
Official Full Name
reticulophagy regulator family member 2provided by HGNC
Primary source
HGNC:HGNC:28450
See related
Ensembl:ENSG00000144567 AllianceGenome:HGNC:28450
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MAG-2; C2orf17; FAM134A
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 39.6), brain (RPKM 29.7) and 25 other tissues See more
Orthologs
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Genomic context

See RETREG2 in Genome Data Viewer
Location:
2q35
Exon count:
10
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (219178275..219185475)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (219666703..219673910)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (220042997..220050197)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 23 member 3 Neighboring gene Sharpr-MPRA regulatory region 9830 Neighboring gene cyclin Pas1/PHO80 domain containing 1 Neighboring gene zinc finger AN1-type containing 2B Neighboring gene ATP binding cassette subfamily B member 6 (Langereis blood group)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC3035, DKFZp686C2379

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables endoplasmic reticulum-autophagosome adaptor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in collagen catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in endoplasmic reticulum organization IEA
Inferred from Electronic Annotation
more info
 
involved_in reticulophagy IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
reticulophagy regulator 2
Names
family with sequence similarity 134 member A
metastasis associated gene-2
protein FAM134A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321109.2NP_001308038.1  reticulophagy regulator 2 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC068946, BC002420, BC141851, BU615764
  2. NM_001321110.2NP_001308039.1  reticulophagy regulator 2 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC068946, AK091011, BU615764, DA172039
    UniProtKB/TrEMBL
    B3KR51
  3. NM_024293.6NP_077269.3  reticulophagy regulator 2 isoform 1

    See identical proteins and their annotated locations for NP_077269.3

    Status: VALIDATED

    Source sequence(s)
    AC068946, AL136758, BC141851, BG700888, BG723788, BU615764
    Consensus CDS
    CCDS2434.1
    UniProtKB/Swiss-Prot
    Q8NC44, Q9H0K7
    Related
    ENSP00000395249.2, ENST00000430297.7

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    219178275..219185475
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005246848.4XP_005246905.1  reticulophagy regulator 2 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    219666703..219673910
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)