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APOO apolipoprotein O [ Homo sapiens (human) ]

Gene ID: 79135, updated on 2-Mar-2021

Summary

Official Symbol
APOOprovided by HGNC
Official Full Name
apolipoprotein Oprovided by HGNC
Primary source
HGNC:HGNC:28727
See related
Ensembl:ENSG00000184831 MIM:300753
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIC26; Mic23; My025; FAM121B; MICOS26
Summary
This gene is a member of the apolipoprotein family. Members of this protein family are involved in the transport and metabolism of lipids. The encoded protein associates with HDL, LDL and VLDL lipoproteins and is characterized by chondroitin-sulfate glycosylation. This protein may be involved in preventing lipid accumulation in the myocardium in obese and diabetic patients. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 4, 5, 12 and 16.[provided by RefSeq, Sep 2009]
Expression
Ubiquitous expression in heart (RPKM 9.7), brain (RPKM 7.6) and 25 other tissues See more
Orthologs
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Genomic context

See APOO in Genome Data Viewer
Location:
Xp22.11
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (23833348..23907938, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (23851470..23926055, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373148 Neighboring gene spermidine/spermine N1-acetyltransferase 1 Neighboring gene ribosomal protein L9 pseudogene 7 Neighboring gene chromosome X open reading frame 58 Neighboring gene Sharpr-MPRA regulatory region 13558 Neighboring gene kelch like family member 15 Neighboring gene eukaryotic translation initiation factor 2 subunit gamma

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC4825

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cristae formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cristae formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
inner mitochondrial membrane organization IC
Inferred by Curator
more info
PubMed 
lipid transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi membrane IDA
Inferred from Direct Assay
more info
PubMed 
MIB complex HDA PubMed 
MICOS complex HDA PubMed 
MICOS complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MICOS complex IDA
Inferred from Direct Assay
more info
PubMed 
SAM complex HDA PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
high-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
 
integral component of mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
low-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
 
mitochondrion HDA PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
very-low-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
MICOS complex subunit MIC26
Names
MICOS complex subunit MIC23
brain my025
family with sequence similarity 121B
mitochondrial contact site and cristae organizing system subunit 26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013219.1 RefSeqGene

    Range
    5003..79588
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_024122.5NP_077027.1  MICOS complex subunit MIC26 precursor

    See identical proteins and their annotated locations for NP_077027.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and is predicted to encode the functional protein.
    Source sequence(s)
    AC079376, BC010102
    Consensus CDS
    CCDS14208.1
    UniProtKB/Swiss-Prot
    Q9BUR5
    Related
    ENSP00000368528.4, ENST00000379226.9
    Conserved Domains (1) summary
    pfam09769
    Location:54177
    ApoO; Apolipoprotein O

RNA

  1. NR_026545.4 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) omits a coding exon resulting in a frameshift and premature stop codon. The transcript is likely non-coding because it is a candidate for nonsense-mediated decay (NMD); therefore, the truncated protein is not annotated.
    Source sequence(s)
    AC079376, AC131011, AF061264
    Related
    ENST00000490078.2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    23833348..23907938 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545587.3XP_011543889.1  MICOS complex subunit MIC26 isoform X3

    See identical proteins and their annotated locations for XP_011543889.1

    Conserved Domains (1) summary
    pfam09769
    Location:18141
    ApoO; Apolipoprotein O
  2. XM_017029837.1XP_016885326.1  MICOS complex subunit MIC26 isoform X2

    UniProtKB/Swiss-Prot
    Q9BUR5
    Related
    ENSP00000402557.1, ENST00000439528.5
    Conserved Domains (1) summary
    pfam09769
    Location:54177
    ApoO; Apolipoprotein O
  3. XM_024452447.1XP_024308215.1  MICOS complex subunit MIC26 isoform X3

    Conserved Domains (1) summary
    pfam09769
    Location:18141
    ApoO; Apolipoprotein O
  4. XM_011545586.2XP_011543888.1  MICOS complex subunit MIC26 isoform X1

    See identical proteins and their annotated locations for XP_011543888.1

    Conserved Domains (1) summary
    pfam09769
    Location:45181
    ApoO; Apolipoprotein O
  5. XM_011545585.2XP_011543887.1  MICOS complex subunit MIC26 isoform X1

    See identical proteins and their annotated locations for XP_011543887.1

    Conserved Domains (1) summary
    pfam09769
    Location:45181
    ApoO; Apolipoprotein O
  6. XM_011545584.2XP_011543886.1  MICOS complex subunit MIC26 isoform X1

    See identical proteins and their annotated locations for XP_011543886.1

    Conserved Domains (1) summary
    pfam09769
    Location:45181
    ApoO; Apolipoprotein O
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