DEK DEK proto-oncogene [Homo sapiens (human)] - Gene

Summary

Official Symbol: DEKprovided by HGNC
Official Full Name: DEK proto-oncogeneprovided by HGNC
Primary source: HGNC:HGNC:2768
See related: Ensembl:ENSG00000124795 MIM:125264
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: D6S231E
Summary: This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Expression: Ubiquitous expression in lymph node (RPKM 58.8), thyroid (RPKM 53.1) and 25 other tissues See more
Orthologs: mouse all

Genomic context

Location:: 6p22.3

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
109.20200815	current	GRCh38.p13 (GCF_000001405.39)	6	NC_000006.12 (18223860..18264541, complement)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (18224400..18264799, complement)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the DEK shRNA cells demonstrated decreased invasive potential than their non-knockdown counterparts control cells.
Title: Optical Redox Imaging Detects the Effects of DEK Oncogene Knockdown on the Redox State of MDA-MB-231 Breast Cancer Cells.
Secreted nuclear protein DEK regulates hematopoiesis through CXCR2 signaling.
Title: Secreted nuclear protein DEK regulates hematopoiesis through CXCR2 signaling.
Knockdown of DEK resulted in inhibition of Gastric Cancer cell migration via a mechanism involving modulation of matrix metalloproteinase MMP-2/MMP-9 level and vice versa.
Title: DEK Is a Potential Biomarker Associated with Malignant Phenotype in Gastric Cancer Tissues and Plasma.
Male schizophrenia subjects had more anterior cingulate cortex DEK protein expression compared to male controls. Female schizophrenia subjects had less DEK protein expression compared to female controls. Finally, while there were no differences in DEK protein expression between control males and control females, males with schizophrenia had higher DEK protein expression compared to females with schizophrenia.
Title: Sex differences in DEK expression in the anterior cingulate cortex and its association with dementia severity in schizophrenia.
DEK is overexpressed in HGSOCs, and decreasing DEK levels significantly reduces cell viability and tumor growth, resulting in apoptotic cell death.
Title: The DEK Oncoprotein Functions in Ovarian Cancer Growth and Survival.
These findings define DEK as an important and multifunctional mediator of homologous recombination.
Title: DEK is required for homologous recombination repair of DNA breaks.
DEK is detected in spontaneously forming neutrophil extracellular traps (NETs) from juvenile idiopathic arthritis patient synovial neutrophils, and DEK-targeted aptamers reduce NETs formation.
Title: DEK-targeting DNA aptamers as therapeutics for inflammatory arthritis.
High DEK proto-oncogene protein (DEK) expression associated with complete response to neoadjuvant chemoradiotherapy.
Title: The potential predictive value of DEK expression for neoadjuvant chemoradiotherapy response in locally advanced rectal cancer.
High DEK expression is associated with cervical cancer tumorigenesis and metastasis.
Title: Silencing DEK downregulates cervical cancer tumorigenesis and metastasis via the DEK/p-Ser9-GSK-3β/p-Tyr216-GSK-3β/β-catenin axis.
The results of the present study demonstrated that EMT of colorectal carcinoma cells was partially mediated by DEK, which likely affected the invasive ability of colorectal carcinoma cells. In addition, cell proliferation and apoptosis were susceptible to DEK silencing.
Title: Epithelial‑mesenchymal transition in colorectal carcinoma cells is mediated by DEK/IMP3.

Submit: New GeneRIF Correction See all GeneRIFs (88)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-36399 (e-PCR)
- UniSTS:23830

D6S2051 (e-PCR)
- UniSTS:83001

SHGC-35904 (e-PCR)
- UniSTS:64065

WI-19135 (e-PCR)
- UniSTS:27213

RH46609 (e-PCR)
- UniSTS:64110

STS-X64229 (e-PCR)
- UniSTS:17299

Homology

Homologs of the DEK gene: The DEK gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog.
Orthologs from Annotation Pipeline: 321 organisms have orthologs with human gene DEK
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
DNA binding	IEA Inferred from Electronic Annotation more info
RNA binding	HDA more info	PubMed
histone binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
histone binding	IDA Inferred from Direct Assay more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
chromatin organization	IEA Inferred from Electronic Annotation more info
positive regulation of gene expression, epigenetic	TAS Traceable Author Statement more info
regulation of double-strand break repair	IBA Inferred from Biological aspect of Ancestor more info	PubMed
regulation of double-strand break repair	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of double-strand break repair via nonhomologous end joining	IEA Inferred from Electronic Annotation more info
regulation of transcription by RNA polymerase II	TAS Traceable Author Statement more info
signal transduction	TAS Traceable Author Statement more info	PubMed
transcription by RNA polymerase II	TAS Traceable Author Statement more info	PubMed
viral genome replication	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
contractile fiber	IEA Inferred from Electronic Annotation more info
nucleoplasm	IDA Inferred from Direct Assay more info
nucleoplasm	TAS Traceable Author Statement more info
nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein DEK

Names: DEK oncogene (DNA binding)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_042290.1 RefSeqGene

Range

5039..45709

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_1375

mRNA and Protein(s)

NM_001134709.2 → NP_001128181.1 protein DEK isoform 2

See identical proteins and their annotated locations for NP_001128181.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (2) is shorter than isoform 1.

Source sequence(s)

AK297749, AL031774, BC035259, BQ574048

Consensus CDS

CCDS47382.1

UniProtKB/Swiss-Prot

P35659

Related

ENSP00000244776.7, ENST00000244776.11

Conserved Domains (2) summary

smart00513
Location:115 → 149

SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation

pfam08766
Location:288 → 340

DEK_C; DEK C terminal domain
NM_003472.4 → NP_003463.1 protein DEK isoform 1

See identical proteins and their annotated locations for NP_003463.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AL031774, BC035259, CN388433

Consensus CDS

CCDS34344.1

UniProtKB/Swiss-Prot

P35659

Related

ENSP00000498653.1, ENST00000652689.1

Conserved Domains (2) summary

smart00513
Location:149 → 183

SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation

pfam08766
Location:320 → 374

DEK_C; DEK C terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

NC_000006.12 Reference GRCh38.p13 Primary Assembly

Range

18223860..18264541 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024446544.1 → XP_024302312.1 protein DEK isoform X2

Related

ENSP00000498335.1, ENST00000652576.1

Conserved Domains (2) summary

smart00513
Location:149 → 183

SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation

pfam08766
Location:320 → 374

DEK_C; DEK C terminal domain
XM_017011273.2 → XP_016866762.1 protein DEK isoform X1

Related

ENSP00000423427.2, ENST00000507591.2

Conserved Domains (2) summary

smart00513
Location:149 → 183

SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation

pfam08766
Location:320 → 373

DEK_C; DEK C terminal domain
XM_024446543.1 → XP_024302311.1 protein DEK isoform X1

Conserved Domains (2) summary

smart00513
Location:149 → 183

SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation

pfam08766
Location:320 → 373

DEK_C; DEK C terminal domain