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DEK DEK proto-oncogene [ Homo sapiens (human) ]

Gene ID: 7913, updated on 3-Oct-2021

Summary

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Official Symbol
DEKprovided by HGNC
Official Full Name
DEK proto-oncogeneprovided by HGNC
Primary source
HGNC:HGNC:2768
See related
Ensembl:ENSG00000124795 MIM:125264
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
D6S231E
Summary
This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Expression
Ubiquitous expression in lymph node (RPKM 58.8), thyroid (RPKM 53.1) and 25 other tissues See more
Orthologs
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Genomic context

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See DEK in Genome Data Viewer
Location:
6p22.3
Exon count:
13
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (18223860..18264541, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (18224091..18264761, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene thiopurine S-methyltransferase Neighboring gene lysine demethylase 1B Neighboring gene Sharpr-MPRA regulatory region 13525 Neighboring gene RNA, U6 small nuclear 263, pseudogene Neighboring gene DEAD-box helicase 18 pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Bacterial Growth Inhibition Screen (BGIS) identifies a loss-of-function mutant of the DEK oncogene, indicating DNA modulating activities of DEK in chromatin. Guo H, et al. FEBS Lett, 2021 May. PMID 33686684
  2. [Construction of RNA interference (RNAi) lentiviral expression vector of DEK gene and its effect on the biological behavior of liver cancer cells]. Li SH, et al. Zhonghua Gan Zang Bing Za Zhi, 2020 Oct 20. PMID 33105933
  3. Role of the DEK oncogene in the development of squamous cell carcinoma. Ishida K, et al. Int J Clin Oncol, 2020 Sep. PMID 32656741, Free PMC Article
  4. DEK promotes the proliferation and invasion of lung cancers and indicates poor prognosis in lung adenocarcinomas. Yang MQ, et al. Oncol Rep, 2020 Apr. PMID 32020224
  5. DEK Is a Potential Biomarker Associated with Malignant Phenotype in Gastric Cancer Tissues and Plasma. Lee KF, et al. Int J Mol Sci, 2019 Nov 13. PMID 31766266, Free PMC Article

See all (199) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. [Prognostic significance of DEK-NUP214 fusion gene in patients with acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation].
    Title: [Prognostic significance of DEK-NUP214 fusion gene in patients with acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation].
  2. Bacterial Growth Inhibition Screen (BGIS) identifies a loss-of-function mutant of the DEK oncogene, indicating DNA modulating activities of DEK in chromatin.
    Title: Bacterial Growth Inhibition Screen (BGIS) identifies a loss-of-function mutant of the DEK oncogene, indicating DNA modulating activities of DEK in chromatin.
  3. MicroRNA-138 promotes neuroblastoma SH-SY5Y cell apoptosis by directly targeting DEK in Alzheimer's disease cell model.
    Title: MicroRNA-138 promotes neuroblastoma SH-SY5Y cell apoptosis by directly targeting DEK in Alzheimer's disease cell model.
  4. Role of the DEK oncogene in the development of squamous cell carcinoma.
    Title: Role of the DEK oncogene in the development of squamous cell carcinoma.
  5. [Construction of RNA interference (RNAi) lentiviral expression vector of DEK gene and its effect on the biological behavior of liver cancer cells].
    Title: [Construction of RNA interference (RNAi) lentiviral expression vector of DEK gene and its effect on the biological behavior of liver cancer cells].
  6. DEK promotes the proliferation and invasion of lung cancers and indicates poor prognosis in lung adenocarcinomas.
    Title: DEK promotes the proliferation and invasion of lung cancers and indicates poor prognosis in lung adenocarcinomas.
  7. the DEK shRNA cells demonstrated decreased invasive potential than their non-knockdown counterparts control cells.
    Title: Optical Redox Imaging Detects the Effects of DEK Oncogene Knockdown on the Redox State of MDA-MB-231 Breast Cancer Cells.
  8. Secreted nuclear protein DEK regulates hematopoiesis through CXCR2 signaling.
    Title: Secreted nuclear protein DEK regulates hematopoiesis through CXCR2 signaling.
  9. Knockdown of DEK resulted in inhibition of Gastric Cancer cell migration via a mechanism involving modulation of matrix metalloproteinase MMP-2/MMP-9 level and vice versa.
    Title: DEK Is a Potential Biomarker Associated with Malignant Phenotype in Gastric Cancer Tissues and Plasma.
  10. Male schizophrenia subjects had more anterior cingulate cortex DEK protein expression compared to male controls. Female schizophrenia subjects had less DEK protein expression compared to female controls. Finally, while there were no differences in DEK protein expression between control males and control females, males with schizophrenia had higher DEK protein expression compared to females with schizophrenia.
    Title: Sex differences in DEK expression in the anterior cingulate cortex and its association with dementia severity in schizophrenia.
Submit: New GeneRIF Correction See all GeneRIFs (94)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding HDA PubMed 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within regulation of double-strand break repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of double-strand break repair via nonhomologous end joining IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 PubMed 
involved_in viral genome replication TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in contractile fiber IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein DEK
Names
DEK oncogene (DNA binding)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042290.1 RefSeqGene

    Range
    5039..45709
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1375

mRNA and Protein(s)

  1. NM_001134709.2 → NP_001128181.1  protein DEK isoform 2

    See identical proteins and their annotated locations for NP_001128181.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK297749, AL031774, BC035259, BQ574048
    Consensus CDS
    CCDS47382.1
    UniProtKB/Swiss-Prot
    P35659
    Related
    ENSP00000244776.7, ENST00000244776.11
    Conserved Domains (2) summary
    smart00513
    Location:115 → 149
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam08766
    Location:288 → 340
    DEK_C; DEK C terminal domain

  2. NM_003472.4 → NP_003463.1  protein DEK isoform 1

    See identical proteins and their annotated locations for NP_003463.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL031774, BC035259, CN388433
    Consensus CDS
    CCDS34344.1
    UniProtKB/Swiss-Prot
    P35659
    Related
    ENSP00000498653.1, ENST00000652689.1
    Conserved Domains (2) summary
    smart00513
    Location:149 → 183
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam08766
    Location:320 → 374
    DEK_C; DEK C terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    18223860..18264541 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446544.1 → XP_024302312.1  protein DEK isoform X2

    Related
    ENSP00000498335.1, ENST00000652576.1
    Conserved Domains (2) summary
    smart00513
    Location:149 → 183
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam08766
    Location:320 → 374
    DEK_C; DEK C terminal domain

  2. XM_017011273.2 → XP_016866762.1  protein DEK isoform X1

    Related
    ENSP00000423427.2, ENST00000507591.2
    Conserved Domains (2) summary
    smart00513
    Location:149 → 183
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam08766
    Location:320 → 373
    DEK_C; DEK C terminal domain

  3. XM_024446543.1 → XP_024302311.1  protein DEK isoform X1

    Conserved Domains (2) summary
    smart00513
    Location:149 → 183
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam08766
    Location:320 → 373
    DEK_C; DEK C terminal domain

RNA

  1. XR_001743635.2 RNA Sequence

    Related
    ENST00000515770.2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35659.1 GenPept UniProtKB/Swiss-Prot:P35659

Gene LinkOut

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