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MYH1 myosin heavy chain 1 [ Equus caballus (horse) ]

Gene ID: 791235, updated on 8-Aug-2025
Official Symbol
MYH1provided by VGNC
Official Full Name
myosin heavy chain 1provided by VGNC
Primary source
VGNC:VGNC:56450
See related
Ensembl:ENSECAG00000024667
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Equus caballus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Also known as
MYHC-2X; MYHC-2d
Orthologs
all
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Try the new Transcripts and proteins table
See MYH1 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2024_12 current TB-T2T (GCF_041296265.1) 11 NC_091694.1 (53184058..53209324, complement)
RS_2024_08 previous assembly EquCab3.0 (GCF_002863925.1) 11 NC_009154.3 (53325909..53350918, complement)

Chromosome 11 - NC_091694.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC106781330 Neighboring gene myosin heavy chain 8 Neighboring gene myosin, heavy chain 4, skeletal muscle pseudogene Neighboring gene myosin heavy chain 2 Neighboring gene uncharacterized LOC102147674 Neighboring gene uncharacterized LOC111775737

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Thoroughbred Stallion gene expression
  • BioProject: PRJEB53382
  • Analysis date: Mon Jan 06 09:53:19 2025

Related articles in PubMed

  1. Myofibre Hyper-Contractility in Horses Expressing the Myosin Heavy Chain Myopathy Mutation, MYH1(E321G). Ochala J, et al. Cells, 2021 Dec 6. PMID 34943936, Free PMC Article
  2. Prevalence of the E321G MYH1 variant for immune-mediated myositis and nonexertional rhabdomyolysis in performance subgroups of American Quarter Horses. Gianino GM, et al. J Vet Intern Med, 2019 Mar. PMID 30623495, Free PMC Article
  3. An E321G MYH1 mutation is strongly associated with nonexertional rhabdomyolysis in Quarter Horses. Valberg SJ, et al. J Vet Intern Med, 2018 Sep. PMID 30079499, Free PMC Article
  4. A missense mutation in MYH1 is associated with susceptibility to immune-mediated myositis in Quarter Horses. Finno CJ, et al. Skelet Muscle, 2018 Mar 6. PMID 29510741, Free PMC Article
  5. Myosin heavy chain isoforms in equine gluteus medius muscle: comparison of mRNA and protein expression profiles. Eizema K, et al. J Histochem Cytochem, 2005 Nov. PMID 15983121

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Myofibre Hyper-Contractility in Horses Expressing the Myosin Heavy Chain Myopathy Mutation, MYH1(E321G).
    Title: Myofibre Hyper-Contractility in Horses Expressing the Myosin Heavy Chain Myopathy Mutation, MYH1(E321G).
  2. Knowing that reining and working cow QHs have the highest prevalence of the E321G MYH1 variant and that the variant is more prevalent than the alleles for hereditary equine regional dermal asthenia and hyperkalemic periodic paralysis in the general QH population will guide the use of genetic testing for diagnostic and breeding purposes.
    Title: Prevalence of the E321G MYH1 variant for immune-mediated myositis and nonexertional rhabdomyolysis in performance subgroups of American Quarter Horses.
  3. This study showed that, while not associated with exertional rhabdomyolysis (ER), the MYH1 mutation is associated with atrophy after ER.
    Title: An E321G MYH1 mutation is strongly associated with nonexertional rhabdomyolysis in Quarter Horses.
  4. It was concluded that a mutation in MYH1 is highly associated with susceptibility to the immune-mediated myositis phenotype in Quarter Horse-related breeds. This is the first report of a mutation in MYH1 and the first link between a skeletal muscle myosin mutation and autoimmune disease.
    Title: A missense mutation in MYH1 is associated with susceptibility to immune-mediated myositis in Quarter Horses.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables microfilament motor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in muscle contraction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of myosin II complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in myosin filament IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
myosin-1
Names
myosin heavy chain 2d
myosin heavy chain 2x
myosin heavy chain, skeletal muscle, adult 1
myosin, heavy chain 1, skeletal muscle, adult

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081759.1 → NP_001075228.1  myosin-1

    See identical proteins and their annotated locations for NP_001075228.1

    Status: PROVISIONAL

    Source sequence(s)
    AB088366
    UniProtKB/Swiss-Prot
    Q8MJV0
    UniProtKB/TrEMBL
    A0A3Q2GYL4
    Related
    ENSECAP00000022162.3, ENSECAT00000026554.3
    Conserved Domains (10) summary
    cl22853
    Location:100 → 769
    Motor_domain; Myosin and Kinesin motor domain
    pfam00063
    Location:88 → 769
    Myosin_head; Myosin head (motor domain)
    pfam01576
    Location:849 → 1926
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:36 → 73
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam07851
    Location:1743 → 1852
    TMPIT; TMPIT-like protein
    pfam13863
    Location:870 → 969
    DUF4200; Domain of unknown function (DUF4200)
    cl00459
    Location:1298 → 1410
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    cl19219
    Location:1669 → 1766
    DUF342; Protein of unknown function (DUF342)
    cl19764
    Location:1375 → 1550
    COG6; Conserved oligomeric complex COG6
    cl23720
    Location:964 → 1097
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_041296265.1-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference TB-T2T Primary Assembly

Genomic

  1. NC_091694.1 Reference TB-T2T Primary Assembly

    Range
    53184058..53209324 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005597036.4 → XP_005597093.1  myosin-1 isoform X1

    See identical proteins and their annotated locations for XP_005597093.1

    UniProtKB/Swiss-Prot
    Q8MJV0
    UniProtKB/TrEMBL
    A0A3Q2GYL4
    Conserved Domains (10) summary
    cl22853
    Location:100 → 769
    Motor_domain; Myosin and Kinesin motor domain
    pfam00063
    Location:88 → 769
    Myosin_head; Myosin head (motor domain)
    pfam01576
    Location:849 → 1926
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:36 → 73
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam07851
    Location:1743 → 1852
    TMPIT; TMPIT-like protein
    pfam13863
    Location:870 → 969
    DUF4200; Domain of unknown function (DUF4200)
    cl00459
    Location:1298 → 1410
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    cl19219
    Location:1669 → 1766
    DUF342; Protein of unknown function (DUF342)
    cl19764
    Location:1375 → 1550
    COG6; Conserved oligomeric complex COG6
    cl23720
    Location:964 → 1097
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MJV0.1 GenPept UniProtKB/Swiss-Prot:Q8MJV0

Gene LinkOut

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