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cd276 CD276 molecule [ Danio rerio (zebrafish) ]

Gene ID: 791140, updated on 9-Sep-2025
Official Symbol
cd276provided by ZNC
Official Full Name
CD276 moleculeprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070112-452
See related
Ensembl:ENSDARG00000003061 AllianceGenome:ZFIN:ZDB-GENE-070112-452
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sc:d0645; zgc:158279
Summary
Predicted to be involved in several processes, including cell surface receptor signaling pathway; cellular response to lipopolysaccharide; and regulation of T cell activation. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including central nervous system; mesoderm; notochord; pronephric duct; and swim bladder bud. Orthologous to human CD276 (CD276 molecule). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
human mouse all
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See cd276 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 18 NC_133193.1 (53568345..53649054, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 18 NC_007129.7 (50443473..50524045, complement)

Chromosome 18 - NC_133193.1Genomic Context describing neighboring genes Neighboring gene inhibitory synaptic factor 1 Neighboring gene uncharacterized LOC141378695 Neighboring gene uncharacterized LOC101884348 Neighboring gene uncharacterized LOC137488347 Neighboring gene zgc:158464 Neighboring gene ubiquitin-like 7b (bone marrow stromal cell-derived) Neighboring gene cyclin B1, like

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. A panel of recombinant monoclonal antibodies against zebrafish neural receptors and secreted proteins suitable for wholemount immunostaining. Staudt N, et al. Biochem Biophys Res Commun, 2015 Jan 2. PMID 25490391, Free PMC Article
  2. RNA-seq liver transcriptome analysis reveals an activated MHC-I pathway and an inhibited MHC-II pathway at the early stage of vaccine immunization in zebrafish. Yang D, et al. BMC Genomics, 2012 Jul 17. PMID 22805612, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in T cell costimulation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
CD276 antigen

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080622.2 → NP_001074091.2  CD276 antigen precursor

    Status: VALIDATED

    Source sequence(s)
    JBMGRA010000018
    UniProtKB/TrEMBL
    A0A8N7UYL5, F1QM89
    Related
    ENSDARP00000123693.2, ENSDART00000150013.4
    Conserved Domains (1) summary
    cl11960
    Location:36 → 117
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133193.1 Reference GRCz12tu Primary Assembly

    Range
    53568345..53649054 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021467709.3 → XP_021323384.1  CD276 antigen isoform X1

    UniProtKB/TrEMBL
    A0A8N7UYL5, F1QM89
    Related
    ENSDARP00000033213.6
    Conserved Domains (1) summary
    cl11960
    Location:36 → 117
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version

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