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PWRN1 Prader-Willi region non-protein coding RNA 1 [ Homo sapiens (human) ]

Gene ID: 791114, updated on 28-Nov-2021

Summary

Official Symbol
PWRN1provided by HGNC
Official Full Name
Prader-Willi region non-protein coding RNA 1provided by HGNC
Primary source
HGNC:HGNC:33235
See related
Ensembl:ENSG00000259905 MIM:611215
Gene type
ncRNA
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NCRNA00198
Summary
This gene is located in the Prader-Willi syndrome (PWS) region of chromosome 15, which is known to undergo imprinting. The transcript is believed to be non-coding. It is bi-allelically expressed in testis and kidney, but mono-allelically expressed from the paternal allele in brain. This gene is poly-adenylated and is known to undergo alternative splicing. Transcript variants may represent part of a complex imprinting center-SNURF-SNRPN transcription unit. The contribution of this gene to the PWS phenotype is unknown, but it has been suggested that it may play a role in establishing paternal imprinting in the PWS region, perhaps by maintaining the paternal allele in an open chromatin configuration. [provided by RefSeq, Sep 2009]
Expression
Restricted expression toward testis (RPKM 11.5) See more
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Genomic context

See PWRN1 in Genome Data Viewer
Location:
15q11.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (24558157..24587780)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (24803304..24832927)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102725165 Neighboring gene Prader-Willi region non-protein coding RNA 3 Neighboring gene nuclear pore associated protein 1 Neighboring gene Sharpr-MPRA regulatory region 9168

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016177.1 RefSeqGene

    Range
    5001..34624
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. NR_026646.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    BC034815
    Related
    ENST00000568609.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    24558157..24587780
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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