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MAPKAP1 MAPK associated protein 1 [ Homo sapiens (human) ]

Gene ID: 79109, updated on 29-Mar-2020

Summary

Official Symbol
MAPKAP1provided by HGNC
Official Full Name
MAPK associated protein 1provided by HGNC
Primary source
HGNC:HGNC:18752
See related
Ensembl:ENSG00000119487 MIM:610558
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIP1; SIN1; JC310; SIN1b; SIN1g
Summary
This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 18.8), testis (RPKM 17.4) and 25 other tissues See more
Orthologs

Genomic context

See MAPKAP1 in Genome Data Viewer
Location:
9q33.3
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (125437394..125707234, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (128199673..128469513, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929014 Neighboring gene uncharacterized LOC112268055 Neighboring gene RNA, U5B small nuclear 5, pseudogene Neighboring gene RNA, 7SL, cytoplasmic 30, pseudogene Neighboring gene uncharacterized LOC102723468 Neighboring gene uncharacterized LOC105376272 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 15 Neighboring gene uncharacterized LOC107987128 Neighboring gene Sharpr-MPRA regulatory region 13831 Neighboring gene VISTA enhancer hs1030 Neighboring gene uncharacterized LOC51145 Neighboring gene PBX homeobox 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2745

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Ras GTPase binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol-3,4,5-trisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol-3,4-bisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol-3,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
TORC2 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
target of rapamycin complex 2 subunit MAPKAP1
Names
MEKK2-interacting protein 1
SAPK-interacting protein 1
TORC2 subunit MAPKAP1
mSIN1
mitogen-activated protein kinase 2-associated protein 1
mitogen-activated protein kinase associated protein 1
ras inhibitor MGC2745
stress-activated map kinase interacting protein 1
stress-activated protein kinase-interacting 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006617.3NP_001006618.1  target of rapamycin complex 2 subunit MAPKAP1 isoform 1

    See identical proteins and their annotated locations for NP_001006618.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as Sin1 and Mip1b, represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL162584, AL358074, AL359632
    Consensus CDS
    CCDS35140.1
    UniProtKB/Swiss-Prot
    Q9BPZ7
    Related
    ENSP00000265960.3, ENST00000265960.8
    Conserved Domains (3) summary
    cd13331
    Location:383490
    PH_Avo1; Avo1 Pleckstrin homology (PH) domain
    pfam05422
    Location:18129
    SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
    pfam16978
    Location:139266
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
  2. NM_001006618.2NP_001006619.1  target of rapamycin complex 2 subunit MAPKAP1 isoform 5

    See identical proteins and their annotated locations for NP_001006619.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), also known as Sin1a, differs in the 3' coding region and UTR, compared to variant 1. The resulting protein (isoform 5), also known as the alpha isoform, has a shorter and distinct C-terminus, compared to isoform 1. The existence of this isoform has not been confirmed experimentally.
    Source sequence(s)
    AY524429, AY524430
    Consensus CDS
    CCDS48020.1
    UniProtKB/Swiss-Prot
    Q9BPZ7
    Related
    ENSP00000377624.3, ENST00000394060.7
    Conserved Domains (2) summary
    pfam05422
    Location:18129
    SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
    pfam16978
    Location:139266
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
  3. NM_001006619.1NP_001006620.1  target of rapamycin complex 2 subunit MAPKAP1 isoform 3

    See identical proteins and their annotated locations for NP_001006620.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as Sin1g, lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting protein (isoform 3), also known as the gamma isoform, is shorter, compared to isoform 1.
    Source sequence(s)
    AY524432, BX438260
    Consensus CDS
    CCDS35139.1
    UniProtKB/Swiss-Prot
    Q9BPZ7
    Related
    ENSP00000362610.2, ENST00000373511.6
    Conserved Domains (3) summary
    cd13331
    Location:353443
    PH_Avo1; Avo1 Pleckstrin homology (PH) domain
    pfam05422
    Location:18129
    SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
    pfam16978
    Location:139266
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
  4. NM_001006620.1NP_001006621.1  target of rapamycin complex 2 subunit MAPKAP1 isoform 4

    See identical proteins and their annotated locations for NP_001006621.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), also known as Sin1d, lacks an alternate in-frame exon in the 5' coding region, and uses a downstream start codon, compared to variant 1. The resulting protein (isoform 4), also known as the delta isoform, has a shorter N-terminus, compared to isoform 1. The existence of this isoform has not been confirmed experimentally. Variants 4 and 5 encode the same isoform (4).
    Source sequence(s)
    AL833042, AY524429, BX438260
    Consensus CDS
    CCDS35141.1
    UniProtKB/Swiss-Prot
    Q9BPZ7
    Related
    ENSP00000362602.3, ENST00000373503.7
    Conserved Domains (2) summary
    cd13331
    Location:191298
    PH_Avo1; Avo1 Pleckstrin homology (PH) domain
    pfam16978
    Location:174
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
  5. NM_001006621.1NP_001006622.1  target of rapamycin complex 2 subunit MAPKAP1 isoform 4

    See identical proteins and their annotated locations for NP_001006622.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), also known as Sin1e, lacks two alternate in-frame exons in the 5' coding region, and uses a downstream start codon, compared to variant 1. The resulting protein (isoform 4), also known as the delta isoform, has a shorter N-terminus, compared to isoform 1. The existence of this isoform has not been confirmed experimentally. Variants 4 and 5 encode the same isoform (4).
    Source sequence(s)
    AL833042, AY524429, BX438260
    Consensus CDS
    CCDS35141.1
    UniProtKB/Swiss-Prot
    Q9BPZ7
    Related
    ENSP00000377627.1, ENST00000394063.5
    Conserved Domains (2) summary
    cd13331
    Location:191298
    PH_Avo1; Avo1 Pleckstrin homology (PH) domain
    pfam16978
    Location:174
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
  6. NM_024117.3NP_077022.1  target of rapamycin complex 2 subunit MAPKAP1 isoform 2

    See identical proteins and their annotated locations for NP_077022.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as Sin1b and Mip1a, lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting protein (isoform 2), also known as the beta isoform, is shorter, compared to isoform 1.
    Source sequence(s)
    AY524429, BC002326, BX438260
    Consensus CDS
    CCDS6864.1
    UniProtKB/Swiss-Prot
    Q9BPZ7
    UniProtKB/TrEMBL
    A0A024R863
    Related
    ENSP00000265961.5, ENST00000350766.7
    Conserved Domains (3) summary
    cd13331
    Location:347454
    PH_Avo1; Avo1 Pleckstrin homology (PH) domain
    pfam05422
    Location:18129
    SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
    pfam16978
    Location:139266
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    125437394..125707234 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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