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TAF1D TATA-box binding protein associated factor, RNA polymerase I subunit D [ Homo sapiens (human) ]

Gene ID: 79101, updated on 7-Jun-2020

Summary

Official Symbol
TAF1Dprovided by HGNC
Official Full Name
TATA-box binding protein associated factor, RNA polymerase I subunit Dprovided by HGNC
Primary source
HGNC:HGNC:28759
See related
Ensembl:ENSG00000166012 MIM:612823
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JOSD3; RAFI41; TAFI41; TAF(I)41
Summary
TAF1D is a member of the SL1 complex, which includes TBP (MIM 600075) and TAF1A (MIM 604903), TAF1B (MIM 604904), and TAF1C (MIM 604905), and plays a role in RNA polymerase I transcription (Wang et al., 2004 [PubMed 15520167]; Gorski et al., 2007 [PubMed 17318177]).[supplied by OMIM, Jun 2009]
Expression
Ubiquitous expression in lymph node (RPKM 25.5), appendix (RPKM 22.4) and 25 other tissues See more
Orthologs

Genomic context

See TAF1D in Genome Data Viewer
Location:
11q21
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (93730194..93741537, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (93463368..93474703, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene N-6 adenine-specific DNA methyltransferase 1 (putative) pseudogene Neighboring gene centrosomal protein 295 Neighboring gene small Cajal body-specific RNA 9 Neighboring gene small nucleolar RNA, H/ACA box 25 Neighboring gene small nucleolar RNA, H/ACA box 32 Neighboring gene small nucleolar RNA, H/ACA box 18 Neighboring gene microRNA 1304 Neighboring gene small nucleolar RNA, C/D box 6 Neighboring gene small nucleolar RNA, H/ACA box 1 Neighboring gene small nucleolar RNA, H/ACA box 8 Neighboring gene small nucleolar RNA, H/ACA box 40 Neighboring gene small nucleolar RNA, C/D box 5 Neighboring gene chromosome 11 open reading frame 54 Neighboring gene Sharpr-MPRA regulatory region 5970 Neighboring gene mediator complex subunit 17

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC5306, FLJ23363, FLJ32621, FLJ46181

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
RNA polymerase transcription factor SL1 complex IEA
Inferred from Electronic Annotation
more info
 
centriolar satellite IDA
Inferred from Direct Assay
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
mitotic spindle IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
TATA box-binding protein-associated factor RNA polymerase I subunit D
Names
Josephin domain containing 3
RNA polymerase I-specific TBP-associated factor 41 kDa
TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TATA box-binding protein-associated factor 1D
TATA-box binding protein associated factor, RNA polymerase I, D
TBP-associated factor 1D
transcription initiation factor SL1/TIF-IB subunit D

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024116.4NP_077021.1  TATA box-binding protein-associated factor RNA polymerase I subunit D

    See identical proteins and their annotated locations for NP_077021.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the functional protein.
    Source sequence(s)
    AP001273, BC001972, BQ774057
    Consensus CDS
    CCDS8293.1
    UniProtKB/Swiss-Prot
    Q9H5J8
    UniProtKB/TrEMBL
    A0A024R3A9
    Related
    ENSP00000410409.2, ENST00000448108.7
    Conserved Domains (1) summary
    pfam15333
    Location:31244
    TAF1D; TATA box-binding protein-associated factor 1D

RNA

  1. NR_146090.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA449756, AP001273, BC001972
  2. NR_146091.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AP001273

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    93730194..93741537 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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