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UQCC3 ubiquinol-cytochrome c reductase complex assembly factor 3 [ Homo sapiens (human) ]

Gene ID: 790955, updated on 1-Jun-2020

Summary

Official Symbol
UQCC3provided by HGNC
Official Full Name
ubiquinol-cytochrome c reductase complex assembly factor 3provided by HGNC
Primary source
HGNC:HGNC:34399
See related
Ensembl:ENSG00000204922 MIM:616097
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MC3DN9; UNQ655; C11orf83; CCDS41658.1
Summary
Complex III is a mitochondrial inner membrane protein complex that transfers electrons from ubiquinol to cytochrome c. This gene encodes a protein that functions in complex III assembly. Mutations in this gene result in Mitochondrial complex III deficiency, nuclear type 9. [provided by RefSeq, Dec 2014]
Expression
Ubiquitous expression in prostate (RPKM 5.0), colon (RPKM 4.9) and 25 other tissues See more
Orthologs

Genomic context

See UQCC3 in Genome Data Viewer
Location:
11q12.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (62671673..62673686)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62439126..62441162)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene chromosome 11 open reading frame 98 Neighboring gene LBH domain containing 1 Neighboring gene small nucleolar RNA, H/ACA box 57 Neighboring gene citrate synthase lysine methyltransferase Neighboring gene UBX domain protein 1 Neighboring gene LRRN4 C-terminal like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC87549

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cardiolipin binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
ATP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
cristae formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrial electron transport, ubiquinol to cytochrome c IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial electron transport, ubiquinol to cytochrome c IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrial respiratory chain complex III assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial respiratory chain complex III assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
ubiquinol-cytochrome-c reductase complex assembly factor 3
Names
UPF0723 protein C11orf83
assembly factor CBP4 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_041802.1 RefSeqGene

    Range
    5020..7033
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001085372.3NP_001078841.1  ubiquinol-cytochrome-c reductase complex assembly factor 3

    See identical proteins and their annotated locations for NP_001078841.1

    Status: REVIEWED

    Source sequence(s)
    AI972746, AP001458, AY358935, BC090057, BF055120, CA422425
    Consensus CDS
    CCDS41658.1
    UniProtKB/Swiss-Prot
    Q6UW78
    Related
    ENSP00000367189.3, ENST00000377953.4
    Conserved Domains (1) summary
    pfam15141
    Location:182
    DUF4574; Domain of unknown function (DUF4574)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    62671673..62673686
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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