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GSK3B glycogen synthase kinase 3 beta [ Bos taurus (domestic cattle) ]

Gene ID: 790875, updated on 5-Sep-2025
Official Symbol
GSK3Bprovided by VGNC
Official Full Name
glycogen synthase kinase 3 betaprovided by VGNC
Primary source
VGNC:VGNC:106762
See related
EnsemblRapid:ENSBTAG00070014348
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
GSK3beta
Orthologs
human mouse all
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See GSK3B in Genome Data Viewer
Location:
chromosome: 1
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 1 NC_037328.1 (64641316..64861897, complement)

Chromosome 1 - NC_037328.1Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 91 Neighboring gene nuclear receptor subfamily 1 group I member 2 Neighboring gene microRNA mir-6529b Neighboring gene microRNA mir-6529a Neighboring gene G protein-coupled receptor 156 Neighboring gene late histone H2B.L4-like Neighboring gene uncharacterized LOC101906506

Genomic Sequence:
NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Role and regulation of Glycogen synthase kinase-3 beta in bovine spermatozoa. Belenky M, et al. Mol Reprod Dev, 2017 Jan. PMID 27864906
  2. GSK3β regulates milk synthesis in and proliferation of dairy cow mammary epithelial cells via the mTOR/S6K1 signaling pathway. Zhang X, et al. Molecules, 2014 Jul 3. PMID 24995926, Free PMC Article
  3. Identification and regulation of glycogen synthase kinase-3 during bovine embryo development. Aparicio IM, et al. Reproduction, 2010 Jul. PMID 20427566
  4. Convergence of 3',5'-cyclic adenosine 5'-monophosphate/protein kinase A and glycogen synthase kinase-3beta/beta-catenin signaling in corpus luteum progesterone synthesis. Roy L, et al. Endocrinology, 2009 Nov. PMID 19819952, Free PMC Article
  5. Biochemical characterization of phospholipids, sulfatide and heparin as potent stimulators for autophosphorylation of GSK-3beta and the GSK-3beta-mediated phosphorylation of myelin basic protein in vitro. Kawakami F, et al. J Biochem, 2008 Mar. PMID 18039685

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggest that maintenance of sperm motility and acrosome reaction timing are mediated by PKA through the regulation of GSK-3 beta activity.
    Title: Role and regulation of Glycogen synthase kinase-3 beta in bovine spermatozoa.
  2. GSK3B and phosphorylated GSK3B regulate milk synthesis and proliferation dairy cow mammary epithelial cells.
    Title: GSK3β regulates milk synthesis in and proliferation of dairy cow mammary epithelial cells via the mTOR/S6K1 signaling pathway.
  3. results suggest that Nav1.7-Ca2+ influx-protein kinase C-alpha pathway activated ERK1/ERK2 and p38, which increased phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation
    Title: Nav1.7-Ca2+ influx-induced increased phosphorylations of extracellular signal-regulated kinase (ERK) and p38 attenuate tau phosphorylation via glycogen synthase kinase-3beta: priming of Nav1.7 gating by ERK and p38.
  4. GSK3B serine phosphorylation was positively correlated with embryo development
    Title: Identification and regulation of glycogen synthase kinase-3 during bovine embryo development.
  5. IGF-I down-regulated functional IGF-I receptor via GSK-3beta inhibition and mTOR activation; constitutive activity of GSK-3beta maintained IGF-I receptor level in nonstimulated cells.
    Title: Homologous posttranscriptional regulation of insulin-like growth factor-I receptor level via glycogen synthase kinase-3beta and mammalian target of rapamycin in adrenal chromaffin cells: effect on tau phosphorylation.
  6. cAMP/PKA regulation of GSK3beta/beta-catenin signaling contributes to the increase in progesterone production in corpus luteum.
    Title: Convergence of 3',5'-cyclic adenosine 5'-monophosphate/protein kinase A and glycogen synthase kinase-3beta/beta-catenin signaling in corpus luteum progesterone synthesis.
  7. These results suggest that phospholipids and sulfatide and heparin may function as effective stimulators for autophosphorylation of GSK-3beta and for the GSK-3beta-mediated phosphorylation of SH-binding proteins, including MBP and tau protein.
    Title: Biochemical characterization of phospholipids, sulfatide and heparin as potent stimulators for autophosphorylation of GSK-3beta and the GSK-3beta-mediated phosphorylation of myelin basic protein in vitro.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables beta-catenin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables tau-protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of beta-catenin destruction complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
glycogen synthase kinase-3 beta
Names
GSK-3beta
NP_001094780.1
XP_024848670.1
XP_024848671.1
XP_059743257.1
XP_059743258.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001101310.1 → NP_001094780.1  glycogen synthase kinase-3 beta

    See identical proteins and their annotated locations for NP_001094780.1

    Status: PROVISIONAL

    Source sequence(s)
    BC146176
    UniProtKB/TrEMBL
    A0AAA9T207, A6H7A9
    Related
    ENSBTAP00070019049.1, ENSBTAT00070032484.1
    Conserved Domains (2) summary
    cd14137
    Location:51 → 356
    STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
    pfam00069
    Location:56 → 353
    Pkinase; Protein kinase domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037328.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    64641316..64861897 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024992902.2 → XP_024848670.1  glycogen synthase kinase-3 beta isoform X1

    UniProtKB/TrEMBL
    A0AAA9T207
    Conserved Domains (1) summary
    cd14137
    Location:51 → 343
    STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3

  2. XM_059887275.1 → XP_059743258.1  glycogen synthase kinase-3 beta isoform X3

    UniProtKB/TrEMBL
    F1MIC3

  3. XM_024992903.2 → XP_024848671.1  glycogen synthase kinase-3 beta isoform X4

    UniProtKB/TrEMBL
    A0A3Q1MT31
    Conserved Domains (1) summary
    cd14137
    Location:51 → 356
    STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3

  4. XM_059887274.1 → XP_059743257.1  glycogen synthase kinase-3 beta isoform X2

    UniProtKB/TrEMBL
    A0A3Q1MT31
    Related
    ENSBTAP00070019033.1, ENSBTAT00070032459.1
Nucleotide Protein Strain
Heading Accession and Version

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