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SLC25A23 solute carrier family 25 member 23 [ Homo sapiens (human) ]

Gene ID: 79085, updated on 10-Sep-2021

Summary

Official Symbol
SLC25A23provided by HGNC
Official Full Name
solute carrier family 25 member 23provided by HGNC
Primary source
HGNC:HGNC:19375
See related
Ensembl:ENSG00000125648 MIM:608746
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APC2; MCSC2; SCAMC3; SCaMC-3
Expression
Ubiquitous expression in brain (RPKM 40.2), thyroid (RPKM 28.7) and 23 other tissues See more
Orthologs
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Genomic context

See SLC25A23 in Genome Data Viewer
Location:
19p13.3
Exon count:
14
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (6436081..6459792, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (6440075..6459803, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene adenylate kinase isoenzyme 1-like Neighboring gene KH-type splicing regulatory protein Neighboring gene microRNA 3940 Neighboring gene solute carrier family 25 member 41 Neighboring gene DENN domain containing 1C Neighboring gene crumbs cell polarity complex component 3 Neighboring gene tubulin beta 4A class IVa

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2615

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium ion binding TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 
located_in mitochondrion TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
calcium-binding mitochondrial carrier protein SCaMC-3
Names
mitochondrial ATP-Mg/Pi carrier protein 2
mitochondrial Ca(2+)-dependent solute carrier protein 2
mitochondrial Ca2+-dependent solute carrier protein 2
short calcium-binding mitochondrial carrier 3
small calcium-binding mitochondrial carrier protein 3
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024103.3NP_077008.2  calcium-binding mitochondrial carrier protein SCaMC-3

    See identical proteins and their annotated locations for NP_077008.2

    Status: VALIDATED

    Source sequence(s)
    AC010503, AJ619962, AW379976, BC001656, BG706035
    Consensus CDS
    CCDS32882.1
    UniProtKB/Swiss-Prot
    Q9BV35
    Related
    ENSP00000301454.3, ENST00000301454.9
    Conserved Domains (3) summary
    COG5126
    Location:7143
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd15897
    Location:1245
    EFh_PEF; EF-hand motif [structural motif]
    cl28162
    Location:190463
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    6436081..6459792 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027287.2XP_016882776.1  calcium-binding mitochondrial carrier protein SCaMC-3 isoform X13

  2. XM_017027292.2XP_016882781.1  calcium-binding mitochondrial carrier protein SCaMC-3 isoform X20

  3. XM_017027286.2XP_016882775.1  calcium-binding mitochondrial carrier protein SCaMC-3 isoform X9

  4. XM_017027288.2XP_016882777.1  calcium-binding mitochondrial carrier protein SCaMC-3 isoform X14

  5. XM_011528275.2XP_011526577.1  calcium-binding mitochondrial carrier protein SCaMC-3 isoform X2

    Conserved Domains (4) summary
    cd00051
    Location:85142
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    PTZ00169
    Location:190463
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:275364
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:1675
    EF-hand_7; EF-hand domain pair
  6. XM_011528279.2XP_011526581.1  calcium-binding mitochondrial carrier protein SCaMC-3 isoform X7

    Conserved Domains (3) summary
    cd00051
    Location:85142
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00153
    Location:232319
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:1675
    EF-hand_7; EF-hand domain pair
  7. XM_011528276.2XP_011526578.1  calcium-binding mitochondrial carrier protein SCaMC-3 isoform X3

    Conserved Domains (4) summary
    cd00051
    Location:85142
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    PTZ00169
    Location:237454
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:232319
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:1675
    EF-hand_7; EF-hand domain pair
  8. XM_011528282.2XP_011526584.1  calcium-binding mitochondrial carrier protein SCaMC-3 isoform X11

    Conserved Domains (3) summary
    cd00051
    Location:85142
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00153
    Location:322411
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:1675
    EF-hand_7; EF-hand domain pair
  9. XM_011528280.2XP_011526582.1  calcium-binding mitochondrial carrier protein SCaMC-3 isoform X8

    Related
    ENSP00000264088.3, ENST00000264088.8
    Conserved Domains (3) summary
    cd00051
    Location:85142
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00153
    Location:322411
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:1675
    EF-hand_7; EF-hand domain pair
  10. XM_017027285.2XP_016882774.1  calcium-binding mitochondrial carrier protein SCaMC-3 isoform X4

  11. XM_011528274.2XP_011526576.1  calcium-binding mitochondrial carrier protein SCaMC-3 isoform X1

    Conserved Domains (4) summary
    cd00051
    Location:85142
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    PTZ00169
    Location:237510
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:322411
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:1675
    EF-hand_7; EF-hand domain pair
  12. XM_011528284.2XP_011526586.1  calcium-binding mitochondrial carrier protein SCaMC-3 isoform X15

    Related
    ENSP00000334537.4, ENST00000334510.9
    Conserved Domains (3) summary
    cd00051
    Location:85142
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00153
    Location:322411
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:1675
    EF-hand_7; EF-hand domain pair
  13. XM_011528277.2XP_011526579.1  calcium-binding mitochondrial carrier protein SCaMC-3 isoform X5

    Conserved Domains (4) summary
    cd00051
    Location:85142
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    PTZ00169
    Location:237510
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:322411
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:1675
    EF-hand_7; EF-hand domain pair
  14. XM_011528283.2XP_011526585.1  calcium-binding mitochondrial carrier protein SCaMC-3 isoform X12

    Conserved Domains (3) summary
    cd00051
    Location:85142
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00153
    Location:322411
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:82137
    EF-hand_7; EF-hand domain pair
  15. XM_011528278.2XP_011526580.1  calcium-binding mitochondrial carrier protein SCaMC-3 isoform X6

    Conserved Domains (4) summary
    cd00051
    Location:85142
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    PTZ00169
    Location:237510
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:322411
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:1675
    EF-hand_7; EF-hand domain pair
  16. XM_017027291.2XP_016882780.1  calcium-binding mitochondrial carrier protein SCaMC-3 isoform X19

    Conserved Domains (3) summary
    COG5126
    Location:7143
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    pfam00153
    Location:185272
    Mito_carr; Mitochondrial carrier protein
    cd15897
    Location:1245
    EFh_PEF; EF-hand motif [structural motif]
  17. XM_017027290.2XP_016882779.1  calcium-binding mitochondrial carrier protein SCaMC-3 isoform X18

    Conserved Domains (3) summary
    COG5126
    Location:7143
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    pfam00153
    Location:185272
    Mito_carr; Mitochondrial carrier protein
    cd15897
    Location:1245
    EFh_PEF; EF-hand motif [structural motif]
  18. XM_017027289.2XP_016882778.1  calcium-binding mitochondrial carrier protein SCaMC-3 isoform X17

  19. XM_011528285.2XP_011526587.1  calcium-binding mitochondrial carrier protein SCaMC-3 isoform X16

    Conserved Domains (4) summary
    cd00051
    Location:85142
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    PTZ00169
    Location:237454
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:232319
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:1675
    EF-hand_7; EF-hand domain pair
  20. XM_011528281.2XP_011526583.1  calcium-binding mitochondrial carrier protein SCaMC-3 isoform X10

    Conserved Domains (4) summary
    cd00051
    Location:85142
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    PTZ00169
    Location:237510
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:322411
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:82137
    EF-hand_7; EF-hand domain pair
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