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WDR77 WD repeat domain 77 [ Homo sapiens (human) ]

Gene ID: 79084, updated on 4-Nov-2018

Summary

Official Symbol
WDR77provided by HGNC
Official Full Name
WD repeat domain 77provided by HGNC
Primary source
HGNC:HGNC:29652
See related
Ensembl:ENSG00000116455 MIM:611734; Vega:OTTHUMG00000011748
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p44; MEP50; MEP-50; HKMT1069; Nbla10071; p44/Mep50
Summary
The protein encoded by this gene is an androgen receptor coactivator that forms a complex with protein arginine methyltransferase 5, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins. The encoded protein may be involved in the early stages of prostate cancer, with most of the protein being nuclear-localized in benign cells but cytoplasmic in cancer cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Expression
Ubiquitous expression in lymph node (RPKM 14.0), urinary bladder (RPKM 11.8) and 25 other tissues See more
Orthologs

Genomic context

See WDR77 in Genome Data Viewer
Location:
1p13.2
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (111439890..111449308, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (111982512..111991915, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene oviductal glycoprotein 1 Neighboring gene UBE2F pseudogene 3 Neighboring gene ATP synthase peripheral stalk-membrane subunit b Neighboring gene chromosome 1 open reading frame 162 Neighboring gene transmembrane and immunoglobulin domain containing 3 Neighboring gene RNA, U6 small nuclear 792, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Chromatin modifying enzymes, organism-specific biosystem (from REACTOME)
    Chromatin modifying enzymes, organism-specific biosystemEukaryotic DNA is associated with histone proteins and organized into a complex nucleoprotein structure called chromatin. This structure decreases the accessibility of DNA but also helps to protect i...
  • Chromatin organization, organism-specific biosystem (from REACTOME)
    Chromatin organization, organism-specific biosystemChromatin organization refers to the composition and conformation of complexes between DNA, protein and RNA. It is determined by processes that result in the specification, formation or maintenance o...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Metabolism of non-coding RNA, organism-specific biosystem (from REACTOME)
    Metabolism of non-coding RNA, organism-specific biosystemThe term non-coding is commonly employed for RNA that does not encode a protein, but this does not mean that such RNAs do not contain information nor have function. There is considerable evidence tha...
  • RMTs methylate histone arginines, organism-specific biosystem (from REACTOME)
    RMTs methylate histone arginines, organism-specific biosystemArginine methylation is a common post-translational modification; around 2% of arginine residues are methylated in rat liver nuclei (Boffa et al. 1977). Arginine can be methylated in 3 different ways...
  • Signaling events mediated by HDAC Class I, organism-specific biosystem (from Pathway Interaction Database)
    Signaling events mediated by HDAC Class I, organism-specific biosystem
    Signaling events mediated by HDAC Class I
  • snRNP Assembly, organism-specific biosystem (from REACTOME)
    snRNP Assembly, organism-specific biosystemSmall nuclear ribonucleoproteins (snRNPs) are crucial for pre-mRNA processing to mRNAs. Each snRNP contains a small nuclear RNA (snRNA) and an extremely stable core of seven Sm proteins. The U6 snRNA...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2722

Gene Ontology Provided by GOA

Function Evidence Code Pubs
methyl-CpG binding IDA
Inferred from Direct Assay
more info
PubMed 
nuclear receptor transcription coactivator activity IGI
Inferred from Genetic Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-arginine N-methyltransferase activity TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IGI
Inferred from Genetic Interaction
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
methylosome IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IGI
Inferred from Genetic Interaction
more info
PubMed 

General protein information

Preferred Names
methylosome protein 50
Names
WD repeat-containing protein 77
androgen receptor cofactor p44
testis tissue sperm-binding protein Li 44a

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317062.1NP_001303991.1  methylosome protein 50 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL390195, BC016946, BI195029, DB105102
    UniProtKB/Swiss-Prot
    Q9BQA1
    Related
    ENSP00000409300.1, OTTHUMP00000013473, ENST00000449340.1, OTTHUMT00000032468
    Conserved Domains (3) summary
    COG2319
    Location:98341
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:128164
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:80331
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_001317063.1NP_001303992.1  methylosome protein 50 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses two alternate in-frame splice junctions in the 3' end compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL390195, AL557974, BC016946, DB105102
    UniProtKB/Swiss-Prot
    Q9BQA1
    Conserved Domains (3) summary
    COG2319
    Location:98327
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:128164
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:80317
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. NM_001317064.1NP_001303993.1  methylosome protein 50 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame segment in the 5' end and uses an alternate in-frame splice junction in the 3' end compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK298179, BC016946, DB105102
    UniProtKB/Swiss-Prot
    Q9BQA1
    Conserved Domains (3) summary
    COG2319
    Location:87258
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:106143
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:88258
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. NM_024102.3NP_077007.1  methylosome protein 50 isoform 2

    See identical proteins and their annotated locations for NP_077007.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction in the 3' end compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BC016946, DB105102
    Consensus CDS
    CCDS835.1
    UniProtKB/Swiss-Prot
    Q9BQA1
    UniProtKB/TrEMBL
    A0A024R0H7
    Related
    ENSP00000235090.5, OTTHUMP00000013472, ENST00000235090.9, OTTHUMT00000032465
    Conserved Domains (3) summary
    COG2319
    Location:98329
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:128164
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:80319
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. NR_133654.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon in the 5' end and uses an alternate splice junction in the 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK296163, BC016946, DB105102

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    111439890..111449308 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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