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DCTPP1 dCTP pyrophosphatase 1 [ Homo sapiens (human) ]

Gene ID: 79077, updated on 9-Dec-2018

Summary

Official Symbol
DCTPP1provided by HGNC
Official Full Name
dCTP pyrophosphatase 1provided by HGNC
Primary source
HGNC:HGNC:28777
See related
Ensembl:ENSG00000179958 MIM:615840
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDA03; RS21C6; XTP3TPA
Summary
The protein encoded by this gene is dCTP pyrophosphatase, which converts dCTP to dCMP and inorganic pyrophosphate. The encoded protein also displays weak activity against dTTP and dATP, but none against dGTP. This protein may be responsible for eliminating excess dCTP after DNA synthesis and may prevent overmethylation of CpG islands. Three transcript variants, one protein-coding and the other two non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015]
Expression
Ubiquitous expression in colon (RPKM 23.2), lymph node (RPKM 13.8) and 25 other tissues See more
Orthologs

Genomic context

See DCTPP1 in Genome Data Viewer
Location:
16p11.2
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (30423698..30430052, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (30435019..30441373, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 771 Neighboring gene small nucleolar RNA, H/ACA box 80C Neighboring gene selenophosphate synthetase 2 Neighboring gene integrin subunit alpha L Neighboring gene RNA, U7 small nuclear 61 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC5627

Gene Ontology Provided by GOA

Function Evidence Code Pubs
dCTP diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dCTP diphosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoside-triphosphate diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoside-triphosphate diphosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
nucleoside-triphosphate diphosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
pyrimidine deoxyribonucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA protection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA protection IMP
Inferred from Mutant Phenotype
more info
PubMed 
dCTP catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dCTP catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT dTTP catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleoside triphosphate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoside triphosphate catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
nucleoside triphosphate catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
protein homotetramerization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dCTP pyrophosphatase 1
Names
XTP3-transactivated gene A protein
XTP3-transactivated protein A
dCTPase 1
deoxycytidine-triphosphatase 1
NP_077001.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024096.1NP_077001.1  dCTP pyrophosphatase 1

    See identical proteins and their annotated locations for NP_077001.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the protein-coding transcript.
    Source sequence(s)
    BC001344
    Consensus CDS
    CCDS10680.1
    UniProtKB/Swiss-Prot
    Q9H773
    Related
    ENSP00000322524.4, ENST00000319285.4
    Conserved Domains (1) summary
    cd11537
    Location:35125
    NTP-PPase_RS21-C6_like; Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs

RNA

  1. NR_134470.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction at the 3' end of the first exon compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    BC001344, BE897551
  2. NR_134471.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate first exon in place of that of variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    BC001344, BE798090

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    30423698..30430052 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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