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TMEM109 transmembrane protein 109 [ Homo sapiens (human) ]

Gene ID: 79073, updated on 17-Jun-2024

Summary

Official Symbol
TMEM109provided by HGNC
Official Full Name
transmembrane protein 109provided by HGNC
Primary source
HGNC:HGNC:28771
See related
Ensembl:ENSG00000110108 MIM:619168; AllianceGenome:HGNC:28771
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SND3; hSND3
Summary
Predicted to enable voltage-gated ion channel activity. Acts upstream of or within cellular response to gamma radiation and negative regulation of cell death. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in fat (RPKM 44.7), lung (RPKM 42.9) and 25 other tissues See more
Orthologs
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Genomic context

See TMEM109 in Genome Data Viewer
Location:
11q12.2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (60914158..60923443)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (60865308..60874594)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (60681630..60690915)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:60673689-60674276 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4781 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4782 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4783 Neighboring gene PRPF19 divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:60679869-60680867 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:60681866-60682864 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4785 Neighboring gene TMEM109 divergent transcript Neighboring gene uncharacterized LOC124902676 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:60686309-60687508 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3377 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3378 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3379 Neighboring gene transmembrane protein 132A Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3380 Neighboring gene solute carrier family 15 member 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4786 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3381 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3382 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4787 Neighboring gene CD6 molecule Neighboring gene RNA, U6 small nuclear 933, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC5508

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables voltage-gated monoatomic cation channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear outer membrane IEA
Inferred from Electronic Annotation
more info
 
located_in sarcoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
voltage-gated monoatomic cation channel TMEM109
Names
SRP-independent targeting 3 homolog
mg23
mitsugumin-23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024092.3NP_076997.1  voltage-gated monoatomic cation channel TMEM109 precursor

    See identical proteins and their annotated locations for NP_076997.1

    Status: VALIDATED

    Source sequence(s)
    AF131803, BC001309, BI463800
    Consensus CDS
    CCDS7996.1
    UniProtKB/Swiss-Prot
    Q9BVC6
    UniProtKB/TrEMBL
    B2R9T9
    Related
    ENSP00000227525.3, ENST00000227525.8
    Conserved Domains (1) summary
    pfam14965
    Location:57231
    BRI3BP; Negative regulator of p53/TP53

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    60914158..60923443
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    60865308..60874594
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)