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TMEM109 transmembrane protein 109 [ Homo sapiens (human) ]

Gene ID: 79073, updated on 2-Mar-2021

Summary

Official Symbol
TMEM109provided by HGNC
Official Full Name
transmembrane protein 109provided by HGNC
Primary source
HGNC:HGNC:28771
See related
Ensembl:ENSG00000110108 MIM:619168
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in fat (RPKM 44.7), lung (RPKM 42.9) and 25 other tissues See more
Orthologs
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Genomic context

See TMEM109 in Genome Data Viewer
Location:
11q12.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (60914158..60923443)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (60681630..60690915)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984333 Neighboring gene uncharacterized LOC105369323 Neighboring gene transmembrane protein 132A Neighboring gene solute carrier family 15 member 3 Neighboring gene CD6 molecule Neighboring gene RNA, U6 small nuclear 933, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC5508

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
voltage-gated ion channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular response to gamma radiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to gamma radiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell death IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear outer membrane IEA
Inferred from Electronic Annotation
more info
 
sarcoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane protein 109
Names
mg23
mitsugumin-23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024092.3NP_076997.1  transmembrane protein 109 precursor

    See identical proteins and their annotated locations for NP_076997.1

    Status: VALIDATED

    Source sequence(s)
    AF131803, BC001309, BI463800
    Consensus CDS
    CCDS7996.1
    UniProtKB/Swiss-Prot
    Q9BVC6
    Related
    ENSP00000227525.3, ENST00000227525.8
    Conserved Domains (1) summary
    pfam14965
    Location:57231
    BRI3BP; Negative regulator of p53/TP53

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    60914158..60923443
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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