U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TMEM109 transmembrane protein 109 [ Homo sapiens (human) ]

Gene ID: 79073, updated on 6-Nov-2022

Summary

Official Symbol
TMEM109provided by HGNC
Official Full Name
transmembrane protein 109provided by HGNC
Primary source
HGNC:HGNC:28771
See related
Ensembl:ENSG00000110108 MIM:619168; AllianceGenome:HGNC:28771
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable voltage-gated ion channel activity. Acts upstream of or within cellular response to gamma radiation and negative regulation of cell death. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in fat (RPKM 44.7), lung (RPKM 42.9) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See TMEM109 in Genome Data Viewer
Location:
11q12.2
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (60914158..60923443)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (60865308..60874594)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (60681630..60690915)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene zona pellucida glycoprotein 1 Neighboring gene pre-mRNA processing factor 19 Neighboring gene uncharacterized LOC124902676 Neighboring gene transmembrane protein 132A Neighboring gene solute carrier family 15 member 3 Neighboring gene CD6 molecule Neighboring gene RNA, U6 small nuclear 933, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC5508

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables voltage-gated ion channel activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in nuclear outer membrane IEA
Inferred from Electronic Annotation
more info
 
located_in sarcoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane protein 109
Names
mg23
mitsugumin-23

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024092.3NP_076997.1  transmembrane protein 109 precursor

    See identical proteins and their annotated locations for NP_076997.1

    Status: VALIDATED

    Source sequence(s)
    AF131803, BC001309, BI463800
    Consensus CDS
    CCDS7996.1
    UniProtKB/Swiss-Prot
    Q9BVC6
    Related
    ENSP00000227525.3, ENST00000227525.8
    Conserved Domains (1) summary
    pfam14965
    Location:57231
    BRI3BP; Negative regulator of p53/TP53

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    60914158..60923443
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    60865308..60874594
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)