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METTL16 methyltransferase 16, N6-methyladenosine [ Homo sapiens (human) ]

Gene ID: 79066, updated on 23-Nov-2021

Summary

Official Symbol
METTL16provided by HGNC
Official Full Name
methyltransferase 16, N6-methyladenosineprovided by HGNC
Primary source
HGNC:HGNC:28484
See related
Ensembl:ENSG00000127804
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
METT10D
Expression
Ubiquitous expression in ovary (RPKM 7.5), thyroid (RPKM 6.7) and 25 other tissues See more
Orthologs
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Genomic context

See METTL16 in Genome Data Viewer
Location:
17p13.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (2416049..2511901, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (2319343..2415182, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ZFP161 motif-containing MPRA enhancer 161/162 Neighboring gene MAX network transcriptional repressor Neighboring gene uncharacterized LOC284009 Neighboring gene RNA, 7SL, cytoplasmic 33, pseudogene Neighboring gene eukaryotic translation initiation factor 4A1 pseudogene 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC3329

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
RNA N6-adenosine-methyltransferase METTL16
Names
N6-adenosine-methyltransferase METTL16
U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase
U6 snRNA methyltransferase
methyltransferase 10 domain containing
methyltransferase 10 domain-containing protein
methyltransferase like 16
methyltransferase-like protein 16
putative methyltransferase METT10D
NP_076991.3
XP_005256858.1
XP_016880535.1
XP_024306696.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024086.4NP_076991.3  RNA N6-adenosine-methyltransferase METTL16

    See identical proteins and their annotated locations for NP_076991.3

    Status: VALIDATED

    Source sequence(s)
    AC006435, BC050603, DB227557
    Consensus CDS
    CCDS42232.1
    UniProtKB/Swiss-Prot
    Q86W50
    Related
    ENSP00000263092.5, ENST00000263092.11
    Conserved Domains (1) summary
    pfam05971
    Location:40291
    Methyltransf_10; Protein of unknown function (DUF890)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    2416049..2511901 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025046.1XP_016880535.1  RNA N6-adenosine-methyltransferase METTL16 isoform X1

    UniProtKB/TrEMBL
    B7Z3X7
    Conserved Domains (2) summary
    pfam02063
    Location:189284
    MARCKS; MARCKS family
    cl17173
    Location:173
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. XM_005256801.3XP_005256858.1  RNA N6-adenosine-methyltransferase METTL16 isoform X1

    See identical proteins and their annotated locations for XP_005256858.1

    UniProtKB/TrEMBL
    B7Z3X7
    Conserved Domains (2) summary
    pfam02063
    Location:189284
    MARCKS; MARCKS family
    cl17173
    Location:173
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  3. XM_024450928.1XP_024306696.1  RNA N6-adenosine-methyltransferase METTL16 isoform X1

    Conserved Domains (2) summary
    pfam02063
    Location:189284
    MARCKS; MARCKS family
    cl17173
    Location:173
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
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