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PRRG3 proline rich and Gla domain 3 [ Homo sapiens (human) ]

Gene ID: 79057, updated on 22-Jun-2021

Summary

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Official Symbol
PRRG3provided by HGNC
Official Full Name
proline rich and Gla domain 3provided by HGNC
Primary source
HGNC:HGNC:30798
See related
Ensembl:ENSG00000130032 MIM:300685
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TMG3; PRGP3
Summary
This gene encodes a protein which contains a vitamin K-dependent carboxylation/gamma-carboxyglutamic domain. The encoded protein is a member of a family of vitamin K-dependent transmembrane proteins which contain a glutamate-rich extracellular domain. [provided by RefSeq, Aug 2011]
Expression
Broad expression in brain (RPKM 1.6), endometrium (RPKM 0.8) and 17 other tissues See more
Orthologs
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Genomic context

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See PRRG3 in Genome Data Viewer
Location:
Xq28
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (151694606..151705924)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (150863079..150874396)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373367 Neighboring gene uncharacterized LOC105377213 Neighboring gene PAS domain containing repressor 1 Neighboring gene fetal and adult testis expressed 1 Neighboring gene cyclic nucleotide gated channel subunit alpha 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of two novel transmembrane gamma-carboxyglutamic acid proteins expressed broadly in fetal and adult tissues. Kulman JD, et al. Proc Natl Acad Sci U S A, 2001 Feb 13. PMID 11171957, Free PMC Article
  2. Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes. Fu GK, et al. Genomics, 2004 Jul. PMID 15203218
  3. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. Otsuki T, et al. DNA Res, 2005. PMID 16303743
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. Huttlin EL, et al. Cell, 2015 Jul 16. PMID 26186194, Free PMC Article
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

See all (8) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC149510, MGC156177

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in integral component of membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

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Preferred Names
transmembrane gamma-carboxyglutamic acid protein 3
Names
proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane)
proline-rich Gla protein 3
proline-rich gamma-carboxyglutamic acid protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016589.1 RefSeqGene

    Range
    5001..11334
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001372163.1 → NP_001359092.1  transmembrane gamma-carboxyglutamic acid protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AF274854
    Related
    ENSP00000501544.1, ENST00000674457.1
    Conserved Domains (1) summary
    pfam00594
    Location:24 → 63
    Gla; Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain

  2. NM_001372165.1 → NP_001359094.1  transmembrane gamma-carboxyglutamic acid protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AF274854
    Related
    ENSP00000501402.1, ENST00000674441.1
    Conserved Domains (1) summary
    pfam00594
    Location:1 → 27
    Gla; Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain

  3. NM_024082.4 → NP_076987.3  transmembrane gamma-carboxyglutamic acid protein 3 isoform 1

    See identical proteins and their annotated locations for NP_076987.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    AF274854, CD631899
    Consensus CDS
    CCDS14699.1
    UniProtKB/Swiss-Prot
    Q9BZD7
    Related
    ENSP00000440217.1, ENST00000538575.5
    Conserved Domains (1) summary
    pfam00594
    Location:24 → 63
    Gla; Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain

RNA

  1. NR_033262.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF274854, AK074574

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    151694606..151705924
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531197.2 → XP_011529499.1  transmembrane gamma-carboxyglutamic acid protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011529499.1

    UniProtKB/Swiss-Prot
    Q9BZD7
    Conserved Domains (1) summary
    pfam00594
    Location:24 → 63
    Gla; Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BZD7.2 GenPept UniProtKB/Swiss-Prot:Q9BZD7

Gene LinkOut

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