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PRRG3 proline rich and Gla domain 3 [ Homo sapiens (human) ]

Gene ID: 79057, updated on 11-Jun-2025
Official Symbol
PRRG3provided by HGNC
Official Full Name
proline rich and Gla domain 3provided by HGNC
Primary source
HGNC:HGNC:30798
See related
Ensembl:ENSG00000130032 MIM:300685; AllianceGenome:HGNC:30798
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TMG3; PRGP3
Summary
This gene encodes a protein which contains a vitamin K-dependent carboxylation/gamma-carboxyglutamic domain. The encoded protein is a member of a family of vitamin K-dependent transmembrane proteins which contain a glutamate-rich extracellular domain. [provided by RefSeq, Aug 2011]
Expression
Broad expression in brain (RPKM 1.6), endometrium (RPKM 0.8) and 17 other tissues See more
Orthologs
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See PRRG3 in Genome Data Viewer
Location:
Xq28
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (151694607..151705924)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (149962930..149974244)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (150863079..150874396)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373367 Neighboring gene uncharacterized LOC105377213 Neighboring gene PAS domain containing repressor 1 Neighboring gene MPRA-validated peak7436 silencer Neighboring gene MPRA-validated peak7437 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21057 Neighboring gene fetal and adult testis expressed 1 Neighboring gene cyclic nucleotide gated channel subunit alpha 2

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • MGC149510, MGC156177

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in blood coagulation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane NAS
Non-traceable Author Statement
more info
PubMed 
Preferred Names
transmembrane gamma-carboxyglutamic acid protein 3
Names
proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane)
proline-rich Gla protein 3
proline-rich gamma-carboxyglutamic acid protein 3

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016589.2 RefSeqGene

    Range
    5853..16319
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001372163.1NP_001359092.1  transmembrane gamma-carboxyglutamic acid protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AF274854
    Consensus CDS
    CCDS14699.1
    UniProtKB/Swiss-Prot
    A1A523, A1A575, Q8N2N6, Q9BZD7
    Related
    ENSP00000501544.1, ENST00000674457.1
    Conserved Domains (1) summary
    pfam00594
    Location:2463
    Gla; Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
  2. NM_001372165.1NP_001359094.1  transmembrane gamma-carboxyglutamic acid protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AF274854
    Consensus CDS
    CCDS94688.1
    UniProtKB/TrEMBL
    A0A6I8PL69
    Related
    ENSP00000501402.1, ENST00000674441.1
    Conserved Domains (1) summary
    pfam00594
    Location:127
    Gla; Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
  3. NM_024082.4NP_076987.3  transmembrane gamma-carboxyglutamic acid protein 3 isoform 1

    See identical proteins and their annotated locations for NP_076987.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    AF274854, CD631899
    Consensus CDS
    CCDS14699.1
    UniProtKB/Swiss-Prot
    A1A523, A1A575, Q8N2N6, Q9BZD7
    Related
    ENSP00000440217.1, ENST00000538575.5
    Conserved Domains (1) summary
    pfam00594
    Location:2463
    Gla; Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain

RNA

  1. NR_033262.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF274854, AK074574

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    151694607..151705924
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    149962930..149974244
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)