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PRRG4 proline rich and Gla domain 4 [ Homo sapiens (human) ]

Gene ID: 79056, updated on 23-Sep-2022

Summary

Official Symbol
PRRG4provided by HGNC
Official Full Name
proline rich and Gla domain 4provided by HGNC
Primary source
HGNC:HGNC:30799
See related
Ensembl:ENSG00000135378 MIM:611690; AllianceGenome:HGNC:30799
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TMG4; PRGP4
Summary
Enables WW domain binding activity. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in esophagus (RPKM 11.6), skin (RPKM 9.5) and 18 other tissues See more
Orthologs
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Genomic context

See PRRG4 in Genome Data Viewer
Location:
11p13
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (32829789..32858120)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (32965209..32993360)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (32851473..32879666)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene 9 Neighboring gene eukaryotic translation initiation factor 3 subunit M Neighboring gene coiled-coil domain containing 73 Neighboring gene 60S ribosomal protein L34-like Neighboring gene ribosomal protein L34 pseudogene 2 Neighboring gene glutamine and serine rich 1 Neighboring gene uncharacterized LOC105376615 Neighboring gene DEP domain containing 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables WW domain binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum-Golgi intermediate compartment membrane IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in membrane NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transmembrane gamma-carboxyglutamic acid protein 4
Names
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
proline-rich Gla protein 4
proline-rich gamma-carboxyglutamic acid protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024081.6NP_076986.1  transmembrane gamma-carboxyglutamic acid protein 4 precursor

    See identical proteins and their annotated locations for NP_076986.1

    Status: VALIDATED

    Source sequence(s)
    AL035400, BC010052, BC063393
    Consensus CDS
    CCDS7881.1
    UniProtKB/Swiss-Prot
    Q9BZD6
    UniProtKB/TrEMBL
    A0A0S2Z5N9
    Related
    ENSP00000257836.3, ENST00000257836.4
    Conserved Domains (1) summary
    pfam00594
    Location:5797
    Gla; Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    32829789..32858120
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718314.4XP_006718377.1  transmembrane gamma-carboxyglutamic acid protein 4 isoform X2

    See identical proteins and their annotated locations for XP_006718377.1

    UniProtKB/Swiss-Prot
    Q9BZD6
    UniProtKB/TrEMBL
    A0A0S2Z5N9
    Conserved Domains (1) summary
    pfam00594
    Location:5797
    Gla; Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
  2. XM_006718313.4XP_006718376.4  transmembrane gamma-carboxyglutamic acid protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A0S2Z5M6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    32965209..32993360
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)