Format

Send to:

Choose Destination

TRPM8 transient receptor potential cation channel subfamily M member 8 [ Homo sapiens (human) ]

Gene ID: 79054, updated on 5-Dec-2021

Summary

Official Symbol
TRPM8provided by HGNC
Official Full Name
transient receptor potential cation channel subfamily M member 8provided by HGNC
Primary source
HGNC:HGNC:17961
See related
Ensembl:ENSG00000144481 MIM:606678
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRPP8; LTRPC6; trp-p8; LTrpC-6
Expression
Restricted expression toward prostate (RPKM 48.0) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See TRPM8 in Genome Data Viewer
Location:
2q37.1
Exon count:
28
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (233917342..234019522)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (234826018..234928166)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene Holliday junction recognition protein Neighboring gene MSL complex subunit 3 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 14260 Neighboring gene Sharpr-MPRA regulatory region 7512 Neighboring gene secreted phosphoprotein 2 Neighboring gene uncharacterized LOC105373932

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study of behavioral disinhibition.
GeneReviews: Not available
Genome-wide association analysis identifies susceptibility loci for migraine without aura.
GeneReviews: Not available
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
GeneReviews: Not available
Genome-wide association study identifies 8 novel loci associated with blood pressure responses to interventions in Han Chinese.
GeneReviews: Not available
Genome-wide association study reveals three susceptibility loci for common migraine in the general population.
GeneReviews: Not available
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2849

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium channel activity TAS
Traceable Author Statement
more info
 
enables cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables ligand-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in calcium ion transmembrane transport TAS
Traceable Author Statement
more info
 
involved_in calcium-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in cation transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in detection of temperature stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in response to cold IEA
Inferred from Electronic Annotation
more info
 
involved_in thermoception IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
transient receptor potential cation channel subfamily M member 8
Names
TRPM8 cationic channel
transient receptor potential p8
transient receptor potential subfamily M member 8

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001397606.1NP_001384535.1  transient receptor potential cation channel subfamily M member 8 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC005538
  2. NM_001397607.1NP_001384536.1  transient receptor potential cation channel subfamily M member 8 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC005538
  3. NM_001397608.1NP_001384537.1  transient receptor potential cation channel subfamily M member 8 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC005538
  4. NM_001397609.1NP_001384538.1  transient receptor potential cation channel subfamily M member 8 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC005538
  5. NM_001397610.1NP_001384539.1  transient receptor potential cation channel subfamily M member 8 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC005538
  6. NM_001397611.1NP_001384540.1  transient receptor potential cation channel subfamily M member 8 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC005538
  7. NM_001397612.1NP_001384541.1  transient receptor potential cation channel subfamily M member 8 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC005538
  8. NM_001397613.1NP_001384542.1  transient receptor potential cation channel subfamily M member 8 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC005538
  9. NM_001397614.1NP_001384543.1  transient receptor potential cation channel subfamily M member 8 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC005538
  10. NM_001397615.1NP_001384544.1  transient receptor potential cation channel subfamily M member 8 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC005538
  11. NM_001397617.1NP_001384546.1  transient receptor potential cation channel subfamily M member 8 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC005538
  12. NM_001397619.1NP_001384548.1  transient receptor potential cation channel subfamily M member 8 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC005538
  13. NM_001397620.1NP_001384549.1  transient receptor potential cation channel subfamily M member 8 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC005538
  14. NM_001397621.1NP_001384550.1  transient receptor potential cation channel subfamily M member 8 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC005538
  15. NM_001397622.1NP_001384551.1  transient receptor potential cation channel subfamily M member 8 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC005538
  16. NM_001397623.1NP_001384552.1  transient receptor potential cation channel subfamily M member 8 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC005538
  17. NM_001397624.1NP_001384553.1  transient receptor potential cation channel subfamily M member 8 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC005538
  18. NM_001397625.1NP_001384554.1  transient receptor potential cation channel subfamily M member 8 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC005538
  19. NM_001397626.1NP_001384555.1  transient receptor potential cation channel subfamily M member 8 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC005538
  20. NM_001397627.1NP_001384556.1  transient receptor potential cation channel subfamily M member 8 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AC005538
  21. NM_001397628.1NP_001384557.1  transient receptor potential cation channel subfamily M member 8 isoform 17

    Status: VALIDATED

    Source sequence(s)
    AC005538
  22. NM_001397629.1NP_001384558.1  transient receptor potential cation channel subfamily M member 8 isoform 17

    Status: VALIDATED

    Source sequence(s)
    AC005538
  23. NM_001397630.1NP_001384559.1  transient receptor potential cation channel subfamily M member 8 isoform 18

    Status: VALIDATED

    Source sequence(s)
    AC005538
  24. NM_001397635.1NP_001384564.1  transient receptor potential cation channel subfamily M member 8 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC005538
  25. NM_024080.5NP_076985.4  transient receptor potential cation channel subfamily M member 8 isoform 1

    See identical proteins and their annotated locations for NP_076985.4

    Status: VALIDATED

    Source sequence(s)
    AC005538, AY090109, BC001135, BC033137
    Consensus CDS
    CCDS33407.1
    UniProtKB/Swiss-Prot
    Q7Z2W7
    UniProtKB/TrEMBL
    W8DTH1
    Related
    ENSP00000323926.4, ENST00000324695.9
    Conserved Domains (1) summary
    pfam00520
    Location:756989
    Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    233917342..234019522
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511810.2XP_011510112.1  transient receptor potential cation channel subfamily M member 8 isoform X1

    Conserved Domains (1) summary
    pfam00520
    Location:756989
    Ion_trans; Ion transport protein
  2. XM_017004891.1XP_016860380.1  transient receptor potential cation channel subfamily M member 8 isoform X2

  3. XM_024453132.1XP_024308900.1  transient receptor potential cation channel subfamily M member 8 isoform X3

    Conserved Domains (1) summary
    cl26777
    Location:580928
    TRP_2; Transient receptor ion channel II
  4. XM_024453133.1XP_024308901.1  transient receptor potential cation channel subfamily M member 8 isoform X4

    Conserved Domains (1) summary
    cl26777
    Location:262610
    TRP_2; Transient receptor ion channel II
  5. XM_024453134.1XP_024308902.1  transient receptor potential cation channel subfamily M member 8 isoform X5

    Conserved Domains (1) summary
    cl26777
    Location:262610
    TRP_2; Transient receptor ion channel II
Support Center