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REEP5 receptor accessory protein 5 [ Homo sapiens (human) ]

Gene ID: 7905, updated on 25-Nov-2021


Official Symbol
REEP5provided by HGNC
Official Full Name
receptor accessory protein 5provided by HGNC
Primary source
See related
Ensembl:ENSG00000129625 MIM:125265
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DP1; TB2; YOP1; POB16; Yip2e; D5S346; C5orf18
Ubiquitous expression in thyroid (RPKM 89.7), brain (RPKM 63.5) and 25 other tissues See more
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Genomic context

See REEP5 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (112876385..112922289, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (112212082..112257924, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene APC regulator of WNT signaling pathway Neighboring gene RNA, U6 small nuclear 482, pseudogene Neighboring gene Sharpr-MPRA regulatory region 9882 Neighboring gene signal recognition particle 19 Neighboring gene X-box binding protein 1 pseudogene 1 Neighboring gene ZRSR2 pseudogene 1 Neighboring gene uncharacterized LOC105379123 Neighboring gene Sharpr-MPRA regulatory region 12983

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?


Associated conditions

Description Tests
Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of receptor accessory protein 5 (REEP5) by siRNA has both activating and inhibiting activities on HIV-1 replication in HeLa P4/R5 cells, suggesting a regulatory role in HIV replication PubMed

Go to the HIV-1, Human Interaction Database


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Clone Names

  • MGC70440

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
enables protein binding IPI
Inferred from Physical Interaction
more info
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
involved_in endoplasmic reticulum membrane organization ISS
Inferred from Sequence or Structural Similarity
more info
involved_in endoplasmic reticulum organization ISS
Inferred from Sequence or Structural Similarity
more info
involved_in regulation of intracellular transport ISS
Inferred from Sequence or Structural Similarity
more info
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
located_in endoplasmic reticulum tubular network IDA
Inferred from Direct Assay
more info
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info

General protein information

Preferred Names
receptor expression-enhancing protein 5
deleted in polyposis 1
polyposis coli region hypothetical protein DP1
polyposis locus protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005669.5NP_005660.4  receptor expression-enhancing protein 5

    See identical proteins and their annotated locations for NP_005660.4

    Status: VALIDATED

    Source sequence(s)
    AC008575, BC000232, DA807043
    Consensus CDS
    ENSP00000368959.4, ENST00000379638.9
    Conserved Domains (1) summary
    TB2_DP1_HVA22; TB2/DP1, HVA22 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly


  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    112876385..112922289 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009844.2XP_016865333.1  receptor expression-enhancing protein 5 isoform X1

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