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REEP5 receptor accessory protein 5 [ Homo sapiens (human) ]

Gene ID: 7905, updated on 9-Feb-2020

Summary

Official Symbol
REEP5provided by HGNC
Official Full Name
receptor accessory protein 5provided by HGNC
Primary source
HGNC:HGNC:30077
See related
Ensembl:ENSG00000129625 MIM:125265
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DP1; TB2; YOP1; POB16; Yip2e; D5S346; C5orf18
Expression
Ubiquitous expression in thyroid (RPKM 89.7), brain (RPKM 63.5) and 25 other tissues See more
Orthologs

Genomic context

See REEP5 in Genome Data Viewer
Location:
5q22.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (112876385..112922289, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (112212081..112258339, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene APC regulator of WNT signaling pathway Neighboring gene RNA, U6 small nuclear 482, pseudogene Neighboring gene Sharpr-MPRA regulatory region 9882 Neighboring gene signal recognition particle 19 Neighboring gene X-box binding protein 1 pseudogene 1 Neighboring gene ZRSR2 pseudogene 1 Neighboring gene uncharacterized LOC105379123 Neighboring gene uncharacterized LOC105379126

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of receptor accessory protein 5 (REEP5) by siRNA has both activating and inhibiting activities on HIV-1 replication in HeLa P4/R5 cells, suggesting a regulatory role in HIV replication PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC70440

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
endoplasmic reticulum tubular network IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
receptor expression-enhancing protein 5
Names
deleted in polyposis 1
polyposis coli region hypothetical protein DP1
polyposis locus protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005669.5NP_005660.4  receptor expression-enhancing protein 5

    See identical proteins and their annotated locations for NP_005660.4

    Status: VALIDATED

    Source sequence(s)
    AC008575, BC000232, DA807043
    Consensus CDS
    CCDS4109.2
    UniProtKB/Swiss-Prot
    Q00765
    Related
    ENSP00000368959.4, ENST00000379638.9
    Conserved Domains (1) summary
    pfam03134
    Location:67144
    TB2_DP1_HVA22; TB2/DP1, HVA22 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    112876385..112922289 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009844.2XP_016865333.1  receptor expression-enhancing protein 5 isoform X1

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