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Spsb3 splA/ryanodine receptor domain and SOCS box containing 3 [ Mus musculus (house mouse) ]

Gene ID: 79043, updated on 14-Feb-2023

Summary

Official Symbol
Spsb3provided by MGI
Official Full Name
splA/ryanodine receptor domain and SOCS box containing 3provided by MGI
Primary source
MGI:MGI:1891471
See related
Ensembl:ENSMUSG00000024160 AllianceGenome:MGI:1891471
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SSB3; Tce1; mKIAA4204; 2310012N15Rik; 3300001M01Rik
Summary
Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to human SPSB3 (splA/ryanodine receptor domain and SOCS box containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 50.0), thymus adult (RPKM 39.1) and 28 other tissues See more
Orthologs
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Genomic context

See Spsb3 in Genome Data Viewer
Location:
17; 17 A3.3
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25104956..25111124)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24885982..24892150)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene hydroxyacyl glutathione hydrolase Neighboring gene fumarylacetoacetate hydrolase domain containing 1 Neighboring gene predicted gene, 41549 Neighboring gene insulin-like growth factor binding protein, acid labile subunit Neighboring gene nucleotide binding protein 2 Neighboring gene essential meiotic structure-specific endonuclease subunit 2 Neighboring gene mitochondrial ribosomal protein S34

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

General gene information

Markers

Homology

Clone Names

  • KIAA4204

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
SPRY domain-containing SOCS box protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163750.2NP_001157222.2  SPRY domain-containing SOCS box protein 3 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1), as well as variants 2, 3, 5, and 6, encodes the longest isoform (a).
    Source sequence(s)
    AC166102
    Consensus CDS
    CCDS50022.1
    UniProtKB/Swiss-Prot
    Q9D7E0
    Related
    ENSMUST00000134932.2
  2. NM_001163751.2NP_001157223.2  SPRY domain-containing SOCS box protein 3 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 5, and 6 all encode the same isoform (a).
    Source sequence(s)
    AC166102
    UniProtKB/Swiss-Prot
    Q9D7E0
  3. NM_001374602.1NP_001361531.1  SPRY domain-containing SOCS box protein 3 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 5, and 6 all encode the same isoform (a).
    Source sequence(s)
    AC166102
    UniProtKB/Swiss-Prot
    Q9D7E0
    Conserved Domains (2) summary
    cd12876
    Location:104286
    SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
    cl02533
    Location:276312
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
  4. NM_001400229.1NP_001387158.1  SPRY domain-containing SOCS box protein 3 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC166102
    UniProtKB/Swiss-Prot
    Q9D7E0
  5. NM_001400231.1NP_001387160.1  SPRY domain-containing SOCS box protein 3 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC166102
  6. NM_001400234.1NP_001387163.1  SPRY domain-containing SOCS box protein 3 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC166102
  7. NM_001400235.1NP_001387164.1  SPRY domain-containing SOCS box protein 3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC166102
  8. NM_001400236.1NP_001387165.1  SPRY domain-containing SOCS box protein 3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC166102
  9. NM_001400237.1NP_001387166.1  SPRY domain-containing SOCS box protein 3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC166102
  10. NM_001400238.1NP_001387167.1  SPRY domain-containing SOCS box protein 3 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC166102
  11. NM_027141.3NP_081417.3  SPRY domain-containing SOCS box protein 3 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 5, and 6 all encode the same isoform (a).
    Source sequence(s)
    AC166102
    Consensus CDS
    CCDS28501.1
    UniProtKB/Swiss-Prot
    Q9D7E0
    Related
    ENSMUSP00000024976.6, ENSMUST00000024976.5

RNA

  1. NR_182655.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC166102

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    25104956..25111124
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525170.5XP_006525233.1  SPRY domain-containing SOCS box protein 3 isoform X6

    See identical proteins and their annotated locations for XP_006525233.1

    UniProtKB/TrEMBL
    D3YW96
    Related
    ENSMUSP00000112589.2, ENSMUST00000119829.8
    Conserved Domains (2) summary
    cd12876
    Location:104311
    SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
    cl02533
    Location:301337
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
  2. XM_006525169.4XP_006525232.1  SPRY domain-containing SOCS box protein 3 isoform X5

    Conserved Domains (2) summary
    cd12876
    Location:135342
    SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
    cl02533
    Location:332368
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
  3. XM_030250150.1XP_030106010.1  SPRY domain-containing SOCS box protein 3 isoform X7

    Related
    ENSMUSP00000068567.7, ENSMUST00000068508.13
    Conserved Domains (1) summary
    cd12876
    Location:135274
    SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
  4. XM_030250149.2XP_030106009.1  SPRY domain-containing SOCS box protein 3 isoform X3

    Conserved Domains (1) summary
    cd12876
    Location:250389
    SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
  5. XM_006525165.4XP_006525228.1  SPRY domain-containing SOCS box protein 3 isoform X1

    Conserved Domains (2) summary
    cd12876
    Location:250457
    SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
    cl02533
    Location:447483
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
  6. XM_006525166.5XP_006525229.1  SPRY domain-containing SOCS box protein 3 isoform X2

    Conserved Domains (1) summary
    cd12876
    Location:250414
    SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
  7. XM_030250151.1XP_030106011.1  SPRY domain-containing SOCS box protein 3 isoform X8

    Related
    ENSMUSP00000112492.2, ENSMUST00000120943.8
    Conserved Domains (2) summary
    cd12876
    Location:104286
    SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
    cl02533
    Location:276312
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
  8. XM_011246733.3XP_011245035.1  SPRY domain-containing SOCS box protein 3 isoform X6

    See identical proteins and their annotated locations for XP_011245035.1

    UniProtKB/TrEMBL
    D3YW96
    Conserved Domains (2) summary
    cd12876
    Location:104311
    SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
    cl02533
    Location:301337
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
  9. XM_006525168.5XP_006525231.1  SPRY domain-containing SOCS box protein 3 isoform X4

    Conserved Domains (2) summary
    cd12876
    Location:139346
    SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
    cl02533
    Location:336372
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
  10. XM_030250153.1XP_030106013.1  SPRY domain-containing SOCS box protein 3 isoform X9

    Conserved Domains (2) summary
    cd12876
    Location:1183
    SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
    cl02533
    Location:173209
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...