U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Spsb3 splA/ryanodine receptor domain and SOCS box containing 3 [ Mus musculus (house mouse) ]

Gene ID: 79043, updated on 7-Apr-2025

Summary

Go to the top of the page Help
Official Symbol
Spsb3provided by MGI
Official Full Name
splA/ryanodine receptor domain and SOCS box containing 3provided by MGI
Primary source
MGI:MGI:1891471
See related
Ensembl:ENSMUSG00000024160 AllianceGenome:MGI:1891471
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SSB3; Tce1; mKIAA4204; 2310012N15Rik; 3300001M01Rik
Summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including negative regulation of cGAS/STING signaling pathway; negative regulation of epithelial to mesenchymal transition; and protein K48-linked ubiquitination. Predicted to be part of Cul5-RING ubiquitin ligase complex and SCF ubiquitin ligase complex. Predicted to be active in nucleus. Orthologous to human SPSB3 (splA/ryanodine receptor domain and SOCS box containing 3). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Ubiquitous expression in testis adult (RPKM 50.0), thymus adult (RPKM 39.1) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Spsb3 in Genome Data Viewer
Location:
17 A3.3; 17 12.53 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25104956..25111124)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24885982..24892150)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene hydroxyacyl glutathione hydrolase Neighboring gene STARR-positive B cell enhancer ABC_E486 Neighboring gene fumarylacetoacetate hydrolase domain containing 1 Neighboring gene predicted gene, 41549 Neighboring gene STARR-seq mESC enhancer starr_42099 Neighboring gene STARR-seq mESC enhancer starr_42100 Neighboring gene insulin-like growth factor binding protein, acid labile subunit Neighboring gene STARR-positive B cell enhancer ABC_E216 Neighboring gene nucleotide binding protein 2 Neighboring gene essential meiotic structure-specific endonuclease subunit 2 Neighboring gene mitochondrial ribosomal protein S34

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Lineage-affiliated transcription factors bind the Gata3 Tce1 enhancer to mediate lineage-specific programs. Ohmura S, et al. J Clin Invest, 2016 Mar 1. PMID 26808502, Free PMC Article
  2. Eleven densely clustered genes, six of them novel, in 176 kb of mouse t-complex DNA. Kargul GJ, et al. Genome Res, 2000 Jul. PMID 10899141, Free PMC Article
  3. The SOCS box: a tale of destruction and degradation. Kile BT, et al. Trends Biochem Sci, 2002 May. PMID 12076535
  4. The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Ray JP, et al. Immunity, 2015 Oct 20. PMID 26410627, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • KIAA4204

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in negative regulation of cGAS/STING signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of epithelial to mesenchymal transition ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein K48-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of Cul5-RING ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
SPRY domain-containing SOCS box protein 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163750.2 → NP_001157222.2  SPRY domain-containing SOCS box protein 3 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1), as well as variants 2, 3, 5, and 6, encodes the longest isoform (a).
    Source sequence(s)
    AC166102
    Consensus CDS
    CCDS50022.1
    UniProtKB/Swiss-Prot
    Q3U0T8, Q571F5, Q6GQX9, Q8C6A9, Q8R4S9, Q9D7E0
    UniProtKB/TrEMBL
    A0A9S4GQ91
    Related
    ENSMUSP00000112492.2, ENSMUST00000120943.8

  2. NM_001163751.2 → NP_001157223.2  SPRY domain-containing SOCS box protein 3 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 5, and 6 all encode the same isoform (a).
    Source sequence(s)
    AC166102
    UniProtKB/Swiss-Prot
    Q3U0T8, Q571F5, Q6GQX9, Q8C6A9, Q8R4S9, Q9D7E0
    UniProtKB/TrEMBL
    A0A9S4GQ91
    Related
    ENSMUSP00000112380.2, ENSMUST00000117890.8

  3. NM_001374602.1 → NP_001361531.1  SPRY domain-containing SOCS box protein 3 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 5, and 6 all encode the same isoform (a).
    Source sequence(s)
    AC166102
    UniProtKB/Swiss-Prot
    Q3U0T8, Q571F5, Q6GQX9, Q8C6A9, Q8R4S9, Q9D7E0
    UniProtKB/TrEMBL
    A0A9S4GQ91
    Conserved Domains (2) summary
    cd12876
    Location:104 → 286
    SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
    cl02533
    Location:276 → 312
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

  4. NM_001400229.1 → NP_001387158.1  SPRY domain-containing SOCS box protein 3 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC166102
    UniProtKB/Swiss-Prot
    Q3U0T8, Q571F5, Q6GQX9, Q8C6A9, Q8R4S9, Q9D7E0
    UniProtKB/TrEMBL
    A0A9S4GQ91

  5. NM_001400231.1 → NP_001387160.1  SPRY domain-containing SOCS box protein 3 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC166102

  6. NM_001400234.1 → NP_001387163.1  SPRY domain-containing SOCS box protein 3 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC166102
    Related
    ENSMUSP00000068567.7, ENSMUST00000068508.13

  7. NM_001400235.1 → NP_001387164.1  SPRY domain-containing SOCS box protein 3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC166102

  8. NM_001400236.1 → NP_001387165.1  SPRY domain-containing SOCS box protein 3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC166102

  9. NM_001400237.1 → NP_001387166.1  SPRY domain-containing SOCS box protein 3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC166102

  10. NM_001400238.1 → NP_001387167.1  SPRY domain-containing SOCS box protein 3 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC166102

  11. NM_027141.3 → NP_081417.3  SPRY domain-containing SOCS box protein 3 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 5, and 6 all encode the same isoform (a).
    Source sequence(s)
    AC166102
    Consensus CDS
    CCDS28501.1
    UniProtKB/Swiss-Prot
    Q3U0T8, Q571F5, Q6GQX9, Q8C6A9, Q8R4S9, Q9D7E0
    UniProtKB/TrEMBL
    A0A9S4GQ91
    Related
    ENSMUSP00000024976.6, ENSMUST00000024976.5

RNA

  1. NR_182655.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC166102
    Related
    ENSMUST00000134932.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    25104956..25111124
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525170.5 → XP_006525233.1  SPRY domain-containing SOCS box protein 3 isoform X6

    See identical proteins and their annotated locations for XP_006525233.1

    UniProtKB/TrEMBL
    A0A9S4GQ91, D3YW96
    Related
    ENSMUSP00000112589.2, ENSMUST00000119829.8
    Conserved Domains (2) summary
    cd12876
    Location:104 → 311
    SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
    cl02533
    Location:301 → 337
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

  2. XM_006525169.4 → XP_006525232.1  SPRY domain-containing SOCS box protein 3 isoform X5

    UniProtKB/TrEMBL
    A0A9S4GQ91
    Conserved Domains (2) summary
    cd12876
    Location:135 → 342
    SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
    cl02533
    Location:332 → 368
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

  3. XM_006525165.4 → XP_006525228.1  SPRY domain-containing SOCS box protein 3 isoform X1

    Conserved Domains (2) summary
    cd12876
    Location:250 → 457
    SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
    cl02533
    Location:447 → 483
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

  4. XM_006525166.5 → XP_006525229.1  SPRY domain-containing SOCS box protein 3 isoform X2

    Conserved Domains (1) summary
    cd12876
    Location:250 → 414
    SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family

  5. XM_011246733.3 → XP_011245035.1  SPRY domain-containing SOCS box protein 3 isoform X6

    See identical proteins and their annotated locations for XP_011245035.1

    UniProtKB/TrEMBL
    A0A9S4GQ91, D3YW96
    Conserved Domains (2) summary
    cd12876
    Location:104 → 311
    SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
    cl02533
    Location:301 → 337
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

  6. XM_006525168.5 → XP_006525231.1  SPRY domain-containing SOCS box protein 3 isoform X4

    UniProtKB/TrEMBL
    A0A9S4GQ91
    Conserved Domains (2) summary
    cd12876
    Location:139 → 346
    SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
    cl02533
    Location:336 → 372
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

  7. XM_030250153.1 → XP_030106013.1  SPRY domain-containing SOCS box protein 3 isoform X9

    Conserved Domains (2) summary
    cd12876
    Location:1 → 183
    SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
    cl02533
    Location:173 → 209
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q571F5.2 GenPept UniProtKB/Swiss-Prot:Q571F5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous