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ZFYVE21 zinc finger FYVE-type containing 21 [ Homo sapiens (human) ]

Gene ID: 79038, updated on 7-Oct-2018

Summary

Official Symbol
ZFYVE21provided by HGNC
Official Full Name
zinc finger FYVE-type containing 21provided by HGNC
Primary source
HGNC:HGNC:20760
See related
Ensembl:ENSG00000100711 MIM:613504; Vega:OTTHUMG00000171651
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZF21; HCVP7TP1
Expression
Ubiquitous expression in fat (RPKM 36.0), endometrium (RPKM 31.2) and 25 other tissues See more
Orthologs

Genomic context

See ZFYVE21 in Genome Data Viewer
Location:
14q32.33
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (103715744..103733668)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (104182081..104200005)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268131 Neighboring gene uncharacterized LOC107984648 Neighboring gene X-ray repair cross complementing 3 Neighboring gene protein phosphatase 1 regulatory subunit 13B Neighboring gene long intergenic non-protein coding RNA 637 Neighboring gene uncharacterized LOC105370690 Neighboring gene uncharacterized LOC105370689

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2550

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
endosome IEA
Inferred from Electronic Annotation
more info
 
focal adhesion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger FYVE domain-containing protein 21
Names
FYVE domain containing 21
HCV p7-transactivated protein 1
zinc finger, FYVE domain containing 21

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198953.1NP_001185882.1  zinc finger FYVE domain-containing protein 21 isoform 1

    See identical proteins and their annotated locations for NP_001185882.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK057816, AL049840, CA311020, CX786145
    Consensus CDS
    CCDS55948.1
    UniProtKB/Swiss-Prot
    Q9BQ24
    Related
    ENSP00000216602.6, OTTHUMP00000246660, ENST00000216602.10, OTTHUMT00000414614
    Conserved Domains (2) summary
    cd15727
    Location:38101
    FYVE_ZF21; FYVE domain found in zinc finger FYVE domain-containing protein 21 (ZF21) and similar proteins
    pfam16696
    Location:108247
    ZFYVE21_C; Zinc finger FYVE domain-containing protein 21 C-terminus
  2. NM_024071.3NP_076976.1  zinc finger FYVE domain-containing protein 21 isoform 2

    See identical proteins and their annotated locations for NP_076976.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BC005999, CA311020, CX786145
    Consensus CDS
    CCDS9985.1
    UniProtKB/Swiss-Prot
    Q9BQ24
    Related
    ENSP00000310543.2, OTTHUMP00000246661, ENST00000311141.6, OTTHUMT00000414616
    Conserved Domains (2) summary
    cd15727
    Location:38101
    FYVE_ZF21; FYVE domain found in zinc finger FYVE domain-containing protein 21 (ZF21) and similar proteins
    pfam16696
    Location:108229
    ZFYVE21_C; Zinc finger FYVE domain-containing protein 21 C-terminus

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    103715744..103733668
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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