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ERI3 ERI1 exoribonuclease family member 3 [ Homo sapiens (human) ]

Gene ID: 79033, updated on 2-Mar-2021

Summary

Official Symbol
ERI3provided by HGNC
Official Full Name
ERI1 exoribonuclease family member 3provided by HGNC
Primary source
HGNC:HGNC:17276
See related
Ensembl:ENSG00000117419 MIM:609917
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PINT1; PRNPIP
Expression
Ubiquitous expression in brain (RPKM 26.0), testis (RPKM 24.6) and 25 other tissues See more
Orthologs
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Genomic context

See ERI3 in Genome Data Viewer
Location:
1p34.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (44221070..44355298, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (44686742..44820951, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene metaxin 3 pseudogene Neighboring gene Sharpr-MPRA regulatory region 23 Neighboring gene ERI3 intronic transcript 1 Neighboring gene VISTA enhancer hs277 Neighboring gene DNA methyltransferase 1 associated protein 1 Neighboring gene small nucleolar RNA, H/ACA box 110 Neighboring gene Sharpr-MPRA regulatory region 3045 Neighboring gene RNA, U6 small nuclear 369, pseudogene Neighboring gene uncharacterized LOC107984951 Neighboring gene ring finger protein 220

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of ERI1 exoribonuclease family member 3 (ERI3) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2683, FLJ22943

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3'-5'-exoribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA binding HDA PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ERI1 exoribonuclease 3
Names
enhanced RNAi three prime mRNA exonuclease homolog 3
prion interactor 1
prion protein-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301698.2NP_001288627.1  ERI1 exoribonuclease 3 isoform 2

    See identical proteins and their annotated locations for NP_001288627.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AF007157, AK290567, BC144384
    UniProtKB/Swiss-Prot
    O43414
    UniProtKB/TrEMBL
    B4DN03
    Conserved Domains (1) summary
    cd06133
    Location:68245
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  2. NM_001301699.1NP_001288628.1  ERI1 exoribonuclease 3 isoform 2

    See identical proteins and their annotated locations for NP_001288628.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in the 5' region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AF007157, AK297708, DC413416
    UniProtKB/Swiss-Prot
    O43414
    UniProtKB/TrEMBL
    B4DN03
    Conserved Domains (1) summary
    cd06133
    Location:68245
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  3. NM_001301700.1NP_001288629.1  ERI1 exoribonuclease 3 isoform 3

    See identical proteins and their annotated locations for NP_001288629.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences, compared to variant 1. These differences result in translation initiation at a downstream start codon and a frameshift, resulting in use of an early stop codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus and a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AF007157, AK293833, BI765887, DC413416
    UniProtKB/Swiss-Prot
    O43414
    UniProtKB/TrEMBL
    B4DEX5
    Conserved Domains (1) summary
    cd06133
    Location:68203
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  4. NM_001301701.1NP_001288630.1  ERI1 exoribonuclease 3 isoform 4

    See identical proteins and their annotated locations for NP_001288630.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' region, compared to variant 1, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AF007157, AK293833, DC413416
    UniProtKB/Swiss-Prot
    O43414
    UniProtKB/TrEMBL
    B4DEX5
    Conserved Domains (1) summary
    cd06133
    Location:1146
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  5. NM_024066.3NP_076971.1  ERI1 exoribonuclease 3 isoform 1

    See identical proteins and their annotated locations for NP_076971.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF007157, AK290567, AK293833
    Consensus CDS
    CCDS30696.1
    UniProtKB/Swiss-Prot
    O43414
    UniProtKB/TrEMBL
    B4DEX5
    Related
    ENSP00000361331.2, ENST00000372257.7
    Conserved Domains (1) summary
    cd06133
    Location:146323
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    44221070..44355298 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002305.1XP_016857794.1  ERI1 exoribonuclease 3 isoform X6

    UniProtKB/TrEMBL
    B4DEX5
    Conserved Domains (1) summary
    cd06133
    Location:1146
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  2. XM_024449712.1XP_024305480.1  ERI1 exoribonuclease 3 isoform X4

    Conserved Domains (1) summary
    cd06133
    Location:68245
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  3. XM_017002303.2XP_016857792.1  ERI1 exoribonuclease 3 isoform X4

    UniProtKB/TrEMBL
    B4DN03
    Conserved Domains (1) summary
    cd06133
    Location:68245
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  4. XM_017002301.1XP_016857790.1  ERI1 exoribonuclease 3 isoform X1

    Conserved Domains (1) summary
    cd06133
    Location:144321
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  5. XM_017002304.2XP_016857793.1  ERI1 exoribonuclease 3 isoform X5

    Related
    ENSP00000396764.1, ENST00000452396.5
    Conserved Domains (1) summary
    cd06133
    Location:35205
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  6. XM_006710891.3XP_006710954.1  ERI1 exoribonuclease 3 isoform X6

    See identical proteins and their annotated locations for XP_006710954.1

    UniProtKB/TrEMBL
    B4DEX5
    Conserved Domains (1) summary
    cd06133
    Location:1146
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  7. XM_005271186.2XP_005271243.1  ERI1 exoribonuclease 3 isoform X2

    See identical proteins and their annotated locations for XP_005271243.1

    Related
    ENSP00000412291.1, ENST00000457571.1
    Conserved Domains (1) summary
    cd06133
    Location:146281
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  8. XM_017002302.1XP_016857791.1  ERI1 exoribonuclease 3 isoform X3

    Conserved Domains (1) summary
    cd06133
    Location:68203
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
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