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DDX50 DExD-box helicase 50 [ Homo sapiens (human) ]

Gene ID: 79009, updated on 9-Dec-2018

Summary

Official Symbol
DDX50provided by HGNC
Official Full Name
DExD-box helicase 50provided by HGNC
Primary source
HGNC:HGNC:17906
See related
Ensembl:ENSG00000107625 MIM:610373
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GU2; GUB; mcdrh; RH-II/GuB
Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box enzyme that may be involved in ribosomal RNA synthesis or processing. This gene and DDX21, also called RH-II/GuA, have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. This gene has pseudogenes on chromosomes 2, 3 and 4. Alternative splicing of this gene generates multiple transcript variants, but the full length nature of all the other variants but one has not been defined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 10.4), thyroid (RPKM 9.2) and 25 other tissues See more
Orthologs

Genomic context

See DDX50 in Genome Data Viewer
Location:
10q22.1
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (68898817..68956312)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (70661034..70706603)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene cell division cycle and apoptosis regulator 1 Neighboring gene small nucleolar RNA, C/D box 98 Neighboring gene storkhead box 1 Neighboring gene RNA, U6 small nuclear 697, pseudogene Neighboring gene RNA, U6 small nuclear 571, pseudogene Neighboring gene DExD-box helicase 21 Neighboring gene mediator complex subunit 28 pseudogene 1 Neighboring gene KIF1 binding protein Neighboring gene ACTB pseudogene 14

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 (DDX50) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC3199

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
helicase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
membrane HDA PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
ATP-dependent RNA helicase DDX50
Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
DEAD box protein 50
DEAD-box helicase 50
RNA helicase II/Gu beta
gu-beta
malignant cell derived RNA helicase
nucleolar protein GU2
NP_076950.1
XP_005270205.1
XP_011538446.1
XP_016872115.1
XP_016872116.1
XP_016872117.1
XP_016872119.1
XP_024303930.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050683.1 RefSeqGene

    Range
    7307..52876
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_024045.2NP_076950.1  ATP-dependent RNA helicase DDX50

    See identical proteins and their annotated locations for NP_076950.1

    Status: REVIEWED

    Source sequence(s)
    AL359844
    Consensus CDS
    CCDS7283.1
    UniProtKB/Swiss-Prot
    Q9BQ39
    Related
    ENSP00000362687.3, ENST00000373585.7
    Conserved Domains (2) summary
    COG0513
    Location:108526
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd12936
    Location:568659
    GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

    Range
    68898817..68956312
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448162.1XP_024303930.1  ATP-dependent RNA helicase DDX50 isoform X2

    Conserved Domains (2) summary
    COG0513
    Location:43461
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd12936
    Location:503594
    GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins
  2. XM_011540144.2XP_011538446.1  ATP-dependent RNA helicase DDX50 isoform X2

    See identical proteins and their annotated locations for XP_011538446.1

    Conserved Domains (2) summary
    COG0513
    Location:43461
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd12936
    Location:503594
    GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins
  3. XM_017016626.1XP_016872115.1  ATP-dependent RNA helicase DDX50 isoform X1

    UniProtKB/Swiss-Prot
    Q9BQ39
    Conserved Domains (2) summary
    COG0513
    Location:108526
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd12936
    Location:568659
    GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins
  4. XM_005270148.2XP_005270205.1  ATP-dependent RNA helicase DDX50 isoform X2

    See identical proteins and their annotated locations for XP_005270205.1

    Conserved Domains (2) summary
    COG0513
    Location:43461
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd12936
    Location:503594
    GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins
  5. XM_017016630.1XP_016872119.1  ATP-dependent RNA helicase DDX50 isoform X3

  6. XM_017016627.1XP_016872116.1  ATP-dependent RNA helicase DDX50 isoform X2

    Conserved Domains (2) summary
    COG0513
    Location:43461
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd12936
    Location:503594
    GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins
  7. XM_017016628.1XP_016872117.1  ATP-dependent RNA helicase DDX50 isoform X2

    Conserved Domains (2) summary
    COG0513
    Location:43461
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd12936
    Location:503594
    GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins
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