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LRFN4 leucine rich repeat and fibronectin type III domain containing 4 [ Homo sapiens (human) ]

Gene ID: 78999, updated on 4-Jul-2021

Summary

Official Symbol
LRFN4provided by HGNC
Official Full Name
leucine rich repeat and fibronectin type III domain containing 4provided by HGNC
Primary source
HGNC:HGNC:28456
See related
Ensembl:ENSG00000173621 MIM:612810
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SALM3; SALM3.; FIGLER6
Expression
Broad expression in fat (RPKM 5.8), colon (RPKM 4.2) and 22 other tissues See more
Orthologs
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Genomic context

See LRFN4 in Genome Data Viewer
Location:
11q13.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (66857064..66860475)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (66624535..66627946)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene chromosome 11 open reading frame 80 Neighboring gene ferritin light chain pseudogene 6 Neighboring gene Ras converting CAAX endopeptidase 1 Neighboring gene pyruvate carboxylase Neighboring gene RNA, U7 small nuclear 23 pseudogene Neighboring gene microRNA 3163

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of LRFN4 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC3103

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of postsynaptic density assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of presynapse assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in synaptic membrane adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in GABA-ergic synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in glutamatergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in integral component of postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
leucine-rich repeat and fibronectin type-III domain-containing protein 4
Names
fibronectin type III, immunoglobulin and leucine rich repeat domains 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363524.2NP_001350453.1  leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AP003176
    Consensus CDS
    CCDS8153.1
    Conserved Domains (5) summary
    cd05764
    Location:295368
    Ig_2; Subgroup of the immunoglobulin (Ig) superfamily
    smart00082
    Location:234278
    LRRCT; Leucine rich repeat C-terminal domain
    sd00033
    Location:5073
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00041
    Location:409478
    fn3; Fibronectin type III domain
    pfam13855
    Location:97157
    LRR_8; Leucine rich repeat
  2. NM_024036.5NP_076941.2  leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor

    See identical proteins and their annotated locations for NP_076941.2

    Status: VALIDATED

    Source sequence(s)
    AP003176, BC015581, CN297399
    Consensus CDS
    CCDS8153.1
    UniProtKB/Swiss-Prot
    Q6PJG9
    UniProtKB/TrEMBL
    A0A024R5I6
    Related
    ENSP00000312535.4, ENST00000309602.5
    Conserved Domains (5) summary
    cd05764
    Location:295368
    Ig_2; Subgroup of the immunoglobulin (Ig) superfamily
    smart00082
    Location:234278
    LRRCT; Leucine rich repeat C-terminal domain
    sd00033
    Location:5073
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00041
    Location:409478
    fn3; Fibronectin type III domain
    pfam13855
    Location:97157
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    66857064..66860475
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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