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CYREN cell cycle regulator of NHEJ [ Homo sapiens (human) ]

Gene ID: 78996, updated on 23-Nov-2021

Summary

Official Symbol
CYRENprovided by HGNC
Official Full Name
cell cycle regulator of NHEJprovided by HGNC
Primary source
HGNC:HGNC:22432
See related
Ensembl:ENSG00000122783 MIM:616980
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRI; MRI-2; C7orf49
Expression
Ubiquitous expression in lung (RPKM 6.0), spleen (RPKM 6.0) and 25 other tissues See more
Orthologs
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Genomic context

See CYREN in Genome Data Viewer
Location:
7q33
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (135092303..135170821, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (134777061..134855459, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986850 Neighboring gene caldesmon 1 Neighboring gene AGBL carboxypeptidase 3 Neighboring gene RNF14 pseudogene 4 Neighboring gene transmembrane protein 140 Neighboring gene WD repeat domain 91 Neighboring gene microRNA 6509 Neighboring gene stimulated by retinoic acid 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC5242, FLJ22450, FLJ27285

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in site of double-strand break ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
cell cycle regulator of non-homologous end joining
Names
modulator of retrovirus infection homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243749.2NP_001230678.1  cell cycle regulator of non-homologous end joining isoform 2

    See identical proteins and their annotated locations for NP_001230678.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate splice site in the coding region, which results in a frameshift, compared to variant 1. Variants 2, 3, 4 and 5 encode the same small ORF (sORF)-encoded polypeptide (SEP) (isoform 2, also known as MRI-2), which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK026103, BC000168, CB961457
    Consensus CDS
    CCDS75663.1
    UniProtKB/Swiss-Prot
    Q9BWK5
  2. NM_001243751.2NP_001230680.1  cell cycle regulator of non-homologous end joining isoform 2

    See identical proteins and their annotated locations for NP_001230680.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the coding region, which results in a frameshift, compared to variant 1. Variants 2, 3, 4 and 5 encode the same small ORF (sORF)-encoded polypeptide (SEP) (isoform 2, also known as MRI-2), which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC000168, BC067350, CB961457
    Consensus CDS
    CCDS75663.1
    UniProtKB/Swiss-Prot
    Q9BWK5
    Related
    ENSP00000389941.2, ENST00000430372.1
  3. NM_001243752.2NP_001230681.1  cell cycle regulator of non-homologous end joining isoform 2

    See identical proteins and their annotated locations for NP_001230681.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate splice site in the coding region, which results in a frameshift, compared to variant 1. Variants 2, 3, 4 and 5 encode the same small ORF (sORF)-encoded polypeptide (SEP) (isoform 2, also known as MRI-2), which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC083862, AI632984, BC000168, BE674385, BM727569, DA213716
    Consensus CDS
    CCDS75663.1
    UniProtKB/Swiss-Prot
    Q9BWK5
    Related
    ENSP00000480430.1, ENST00000617987.1
  4. NM_001243753.2NP_001230682.1  cell cycle regulator of non-homologous end joining isoform 2

    See identical proteins and their annotated locations for NP_001230682.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate splice site in the coding region, which results in a frameshift, compared to variant 1. Variants 2, 3, 4 and 5 encode the same small ORF (sORF)-encoded polypeptide (SEP) (isoform 2, also known as MRI-2), which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC083862, BC000168, BG770658
    Consensus CDS
    CCDS75663.1
    UniProtKB/Swiss-Prot
    Q9BWK5
  5. NM_001243754.2NP_001230683.1  cell cycle regulator of non-homologous end joining isoform 3

    See identical proteins and their annotated locations for NP_001230683.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate splice site and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 6 and 7 encode the same isoform (3), which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    BC000168, BQ423284
    Consensus CDS
    CCDS59082.1
    UniProtKB/Swiss-Prot
    Q9BWK5
    Related
    ENSP00000473365.1, ENST00000483029.2
    Conserved Domains (1) summary
    pfam15325
    Location:1102
    MRI; Modulator of retrovirus infection
  6. NM_001243755.2NP_001230684.1  cell cycle regulator of non-homologous end joining isoform 3

    See identical proteins and their annotated locations for NP_001230684.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, uses an alternate splice site and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 6 and 7 encode the same isoform (3), which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC083862, AL708733, BC000168
    Consensus CDS
    CCDS59082.1
    UniProtKB/Swiss-Prot
    Q9BWK5
    Related
    ENSP00000481014.1, ENST00000620897.4
    Conserved Domains (1) summary
    pfam15325
    Location:1102
    MRI; Modulator of retrovirus infection
  7. NM_001305629.2NP_001292558.1  cell cycle regulator of non-homologous end joining isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) uses an alternate splice site and lacks an alternate exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AC083862, BC067350, HY026093
    UniProtKB/Swiss-Prot
    Q9BWK5
    Conserved Domains (1) summary
    pfam15325
    Location:59144
    MRI; Modulator of retrovirus infection
  8. NM_001305630.2NP_001292559.1  cell cycle regulator of non-homologous end joining isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) uses an alternate splice site, lacks a portion of the 3' coding region, and contains an alternate 3' terminal exon, resulting in a distinct 3' UTR, compared to variant 1. The encoded isoform (5) has a shorter and distinct C-terminus than isoform 1.
    Source sequence(s)
    AC083862, AI335567, BC050676, CB961457
    Related
    ENST00000459937.5
  9. NM_001363329.2NP_001350258.1  cell cycle regulator of non-homologous end joining isoform 1

    Status: VALIDATED

    Source sequence(s)
    BC000168, BP213903, CB132932
    Consensus CDS
    CCDS5838.2
    Conserved Domains (1) summary
    pfam15325
    Location:52157
    MRI; Modulator of retrovirus infection
  10. NM_001363330.2NP_001350259.1  cell cycle regulator of non-homologous end joining isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC083862, BC000168, BE674385, BP213903, CB132932
    Consensus CDS
    CCDS5838.2
    Conserved Domains (1) summary
    pfam15325
    Location:52157
    MRI; Modulator of retrovirus infection
  11. NM_024033.4NP_076938.2  cell cycle regulator of non-homologous end joining isoform 1

    See identical proteins and their annotated locations for NP_076938.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1, also known as MRI-1).
    Source sequence(s)
    AC083862
    Consensus CDS
    CCDS5838.2
    UniProtKB/Swiss-Prot
    Q9BWK5
    Related
    ENSP00000376823.3, ENST00000393114.8
    Conserved Domains (1) summary
    pfam15325
    Location:52157
    MRI; Modulator of retrovirus infection

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    135092303..135170821 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012595.1XP_016868084.1  cell cycle regulator of non-homologous end joining isoform X4

    UniProtKB/Swiss-Prot
    Q9BWK5
  2. XM_017012592.2XP_016868081.1  cell cycle regulator of non-homologous end joining isoform X2

    Conserved Domains (1) summary
    pfam15325
    Location:59144
    MRI; Modulator of retrovirus infection
  3. XM_017012594.2XP_016868083.1  cell cycle regulator of non-homologous end joining isoform X3

    UniProtKB/Swiss-Prot
    Q9BWK5
    Related
    ENSP00000400024.1, ENST00000424142.5
    Conserved Domains (1) summary
    pfam15325
    Location:1102
    MRI; Modulator of retrovirus infection
  4. XM_024446930.1XP_024302698.1  cell cycle regulator of non-homologous end joining isoform X3

    Conserved Domains (1) summary
    pfam15325
    Location:1102
    MRI; Modulator of retrovirus infection
  5. XM_017012593.2XP_016868082.1  cell cycle regulator of non-homologous end joining isoform X3

    UniProtKB/Swiss-Prot
    Q9BWK5
    Conserved Domains (1) summary
    pfam15325
    Location:1102
    MRI; Modulator of retrovirus infection
  6. XM_017012591.2XP_016868080.1  cell cycle regulator of non-homologous end joining isoform X1

    UniProtKB/Swiss-Prot
    Q9BWK5
    Conserved Domains (1) summary
    pfam15325
    Location:52157
    MRI; Modulator of retrovirus infection
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