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PCYOX1L prenylcysteine oxidase 1 like [ Homo sapiens (human) ]

Gene ID: 78991, updated on 8-Jul-2021

Summary

Official Symbol
PCYOX1Lprovided by HGNC
Official Full Name
prenylcysteine oxidase 1 likeprovided by HGNC
Primary source
HGNC:HGNC:28477
See related
Ensembl:ENSG00000145882
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in testis (RPKM 5.8), brain (RPKM 5.2) and 24 other tissues See more
Orthologs
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Genomic context

See PCYOX1L in Genome Data Viewer
Location:
5q32
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (149358046..149369653)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (148737609..148749216)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene actin filament associated protein 1 like 1 Neighboring gene GRPEL2 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 10017 Neighboring gene GrpE like 2, mitochondrial Neighboring gene uncharacterized LOC101927046 Neighboring gene interleukin 17B Neighboring gene VISTA enhancer hs1752 Neighboring gene cardiac mesoderm enhancer-associated non-coding RNA

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC3265

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables prenylcysteine oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in prenylated protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in prenylcysteine catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in membrane HDA PubMed 
located_in platelet alpha granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
prenylcysteine oxidase-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301054.2NP_001287983.1  prenylcysteine oxidase-like isoform 2

    See identical proteins and their annotated locations for NP_001287983.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longest transcript. It has an alternate splice site in the 5' region, which results in an alternate translation initiation site, compared to variant 1. The resulting isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AF451985, AK090410, DA368718, DB573610
    UniProtKB/Swiss-Prot
    Q8NBM8
    Conserved Domains (2) summary
    pfam07156
    Location:105466
    Prenylcys_lyase; Prenylcysteine lyase
    pfam13450
    Location:1479
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  2. NM_001301057.2NP_001287986.1  prenylcysteine oxidase-like isoform 3

    See identical proteins and their annotated locations for NP_001287986.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate splice site in the 5' region, which results in an alternate translation initiation site, and has an alternate in-frame splice site in the central region, compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus and lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AK090410, BC000014, DA368718, DB573610
    UniProtKB/Swiss-Prot
    Q8NBM8
    Conserved Domains (2) summary
    pfam07156
    Location:105407
    Prenylcys_lyase; Prenylcysteine lyase
    pfam13450
    Location:1479
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  3. NM_024028.4NP_076933.3  prenylcysteine oxidase-like isoform 1 precursor

    See identical proteins and their annotated locations for NP_076933.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK075414, BP397957, DA368718
    Consensus CDS
    CCDS4296.1
    UniProtKB/Swiss-Prot
    Q8NBM8
    Related
    ENSP00000274569.4, ENST00000274569.9
    Conserved Domains (2) summary
    pfam07156
    Location:122483
    Prenylcys_lyase; Prenylcysteine lyase
    pfam13450
    Location:3196
    NAD_binding_8; NAD(P)-binding Rossmann-like domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    149358046..149369653
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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